Profile photo Michiel van der Flier

Michiel van der Flier

Assistant Professor - medical

Strategic program(s):

Biography

Michiel van der Flier (Utrecht, 1970) studied medicine at Utrecht University. As a student he was a guest investigator at the Rockefeller University, New York, US. He trained as a paediatrician at the Wilhelmina Children's Hospital/UMC Utrecht and St Antonius Hospital Nieuwegein. He earned his PhD  in 2003 at Utrecht University on the thesis “VEGF in sepsis and meningitis”.  He did his subspecialty training in Paediatric Infectious Diseases and Immunology at the  Sophia Children's Hospital-ErasmusMC in Rotterdam and at the Great Ormond Street Hospital for Sick Children in Londen. From 2009 to 2018 he worked as a consultant  in Paediatric Infectious Diseases and Immunology at the Amalia Children's Hospital-Radboudumc in Nijmegen and from 2014 to 2018 he served as program manager of the subspecialty .  In 2017-2018 he worked half a year as Honorary Clinical Senior Lecturer in St Mary’s Hospital, Imperial College, in Londen. Starting November 2018 he returned to the UMC Utrecht. He combines the care for children with infections and immunodeficiencies  in the Wilhelmina Children's Hospital and the Princess Maxima Centre for Paediatric Oncology with research and teaching.  

Recent publications

Genetic Determinants of the Complement and Coagulation Pathways in Invasive Meningococcal Disease Evangelos Bellos, Karin van Leeuwen, Amedine Duret, Stephanie Hodeib, Meg Mashbat, Daniela S Kohlfuerst, Navin P Boeddha, Luregn J Schlapbach, Victoria J Wright, Colin G Fink, Michiel van der Flier, Marcel van Deuren, Tom Sprong, Margarita López Trascasa, Alberto López Lera, Federico Martinón-Torres, Antonio Salas, Dilys Santillo, Werner Zenz, Gertjan J Driessen, Suzanne T Anderson, Fatou Secka, Stephane Paulus, Ronald de Groot, Marieke Emonts, Enitan D Carrol, Jethro Herberg, Mike Levin, Vanessa Sancho-Shimizu, Taco Kuijpers,
The Journal of Allergy and Clinical Immunology, 2025, vol. 156, p.1743-1751.e4
Procalcitonin use in febrile children attending European emergency departments Dorine M. Borensztajn, Joany M. Zachariasse, Enitan D. Carrol, Ruud G. Nijman, Ulrich von Both, Marieke Emonts, Jethro Herberg, Benno Kohlmaier, Michael Levin, Emma Lim, Ian K. Maconochie, Federico Martinón-Torres, Marko Pokorn, Irene Rivero-Calle, Aleksandra Rudzāte, Chantal D. Tan, Maria Tsolia, Clementien Vermont, Dace Zavadska, Werner Zenz, Henriette A. Moll, Esther Willems, Ria Philipsen, Martijn Huijnen, Stefanie Henriet, Alain J. van Gool, Jolein Gloerich, Bryan van den Broek, Wynand Alkema, Koen van Aerde, Marien I. de Jonge, Michiel van der Flier, Ronald de Groot, Kelly Syggelou, Marietta Xagorari, Antonis Marmarinos, Maria Tambouratzi, Urzula Nora Urbāne, Dace Svile, Aleksandra Sidorova, Katrīna Selecka, Zanda Pučuka, Jana Pavāre, Ieva Nokalna, Anija Meiere, Ilze Grope, Dagne Grāvele, Dace Gardovska, Dārta Deksne, Arta Bārzdiņa,
BMC Pediatrics, 2025, vol. 25
Immunity to Streptococcus pyogenes and Common Respiratory Viruses at Age 0 to 4 Years After COVID-19 Restrictions Kitt Dokal, Samuel Channon-Wells, Catherine Davis, Diego Estrada-Rivadeneyra, Kristin K. Huse, Amelia Lias, Shea Hamilton, Rebecca L. Guy, Theresa Lamagni, Sam Nichols, Andrew Taylor, Philipp K.A. Agyeman, Amutha Anpananthar, Romain Basmaci, Enitan D. Carrol, Michael J. Carter, Tisham De, Marien I. de Jonge, Marieke Emonts, Leire Estramiana Elorrieta, Katy Fidler, Mojca Kolnik, Taco W. Kuijpers, Federico Martinon-Torres, Henriette Moll, Marine Mommert-Tripon, Samira Neshat, Maggie Nyirenda-Nyang'wa, Sean O'Riordan, Daniel R. Owens, Nazima Pathan, Stephane Paulus, Mark J. Peters, Marko Pokorn, Andrew J. Pollard, Irene Rivero-Calle, Pablo Rojo, Lorenza Romani, Prita Rughani, Luregn J. Schlapbach, Nina A. Schweintzger, Ching Fen Shen, Artur Sulik, Maria Tsolia, Effua Usuf, Michiel van der Flier, Clementien Vermont, Ulrich von Both, Paul Wellman, Victoria J. Wright,
JAMA network open, 2025, vol. 8, p.1-16
Antibody dependent complement activation is critical for boosting opsonophagocytosis of Staphylococcus epidermidis in an extremely preterm human whole blood model Coco R Beudeker, Rob van Dalen, Maartje Ruyken, Carla J C de Haas, Lisette M Scheepmaker, Daniel Vijlbrief, A Titia Lely, Kok P M van Kessel, Jan-Tom van der Bruggen, Suzan H M Rooijakkers, Leire Aguinagalde Salazar, Michiel van der Flier
Scientific Reports, 2025, vol. 15
Host gene expression signatures to identify infection type and organ dysfunction in children evaluated for sepsis Luregn J. Schlapbach, Devika Ganesamoorthy, Clare Wilson, Sainath Raman, Shane George, Peter J. Snelling, Natalie Phillips, Adam Irwin, Natalie Sharp, Renate Le Marsney, Arjun Chavan, Allison Hempenstall, Seweryn Bialasiewicz, Anna D. MacDonald, Keith Grimwood, Jessica C. Kling, Stephen J. McPherson, Antje Blumenthal, Myrsini Kaforou, Michael Levin, Jethro A. Herberg, Kristen S. Gibbons, Lachlan Coin, Lachlan Coin, Stuart Gormley, Shea Hamilton, Clive Hoggart, Vanessa Sancho-Shimizu, Victoria Wright, Amina Abdulla, Paul Agapow, Maeve Bartlett, Hariklia Eleftherohorinou, Rachel Galassini, David Inwald, Meg Mashbat, R. de Groot, M. van der Flier, T. W. Kuijpers, E. A.M. Sanders, M. A. Breukels, E. de Vries, W. J. de Waal, R. Dekkers, J. Heidema, N. J.G. Jansen, C. J. Miedema, H. van der Meer, T. F.W. Wolfs, Gibbi Sey, ,
The Lancet Child and Adolescent Health, 2024, vol. 8, p.325-338
Clinical efficacy of SARS-CoV-2 Omicron-neutralizing antibodies in immunoglobulin preparations for the treatment of agammaglobulinemia in patients with primary antibody deficiency Michael Karbiener, Gerhard Kindle, Isabelle Meyts, Mikko R.J. Seppänen, Fabio Candotti, Marta Kamieniak, Reinhard Ilk, Thomas R. Kreil, Markus G. Seidel, Dalia Abd Elaziz, Lofty M. Abdelkader Sohilla, Avigaelle Abitbol, Abolhassani Hassan, Lalash Abrahim, Mohamed Abuzakouk, Moussouni Nabila Achir, Veronica Afonso, Philipp Agyeman, Martina Ahlmann, Alessandro Aiuti, Abla Akl, Güzide Aksu, Kim Albers, Michael Albert, Meda Diana Alecsandru, Olga Aleinikova, Svetlana Aleshkevich, Luis Allende, Mickael Alligon, Zoe Allwood, Manrique de Lara Laia Alsina, Daniela Ambrosch‐barsoumian, Lisa Ameshofer, Kenza Amour, Evrim Anadol, Ariharan Ananthachagaran, Chantal Andriamanga, Julia Andris, Karin Andritschke, Federica Angelini, Tobias Ankermann, Jaap Jan Boelens, P. M. Ellerbroek, Lucy Gossens, Ellen Schatorje, Annick van de Ven, Michiel van der Flier, J. M. van Montfrans, Annet van Royen-Kerkhof, Nico M. Wulffraat,
Journal of Medical Virology, 2024, vol. 96

Fellowships & Awards

2020         Wilhelmina Research Fund Grant 2019-2020

2006         ESPID Fellowship

1998         AGIKO Stipendium ZonMw

1995         WKZ Award “Best student researchproject"

1993         Free-Mover Stipendium STIR-fund

Research Grants (selection)

2023-present             Effect of Anti-Group B streptococcus (GBS) monoclonal antibodies in human (preterm) neonatal anti-GBS host defense assays. Minervax.  PI

2021-present             RUBY (Rna umbilical cord blood sepsis diagnosis in newborn baby’s) Elisabeth von Freyburg Fund  PI

2021-2023                        Boosting host-defence to protect against neonatal GBS sepsis. Vaillant Fund 

2020-present                    DIAMONDS (Diagnosis and Management Of febrile illness using RNA Personalized Molecular Signature Diagnosis) EU H2020 project PI UMCUtrecht Co-lead Clinical working Party Immunocompromised patients.

2020-2024                PEARLS       (Boosting host-defence to prevent and treat neonatal sepsis) WKZ Research fund 

2017-present           Exhaled breath analysis to distinguish viral from bacterial aetiology of lower respiratory tract infections in children. ESPID Fellowship, European Society for Paediatric Infectious Diseases. Supervisor of recipient (Koen van Aerde).

2016-2019           PERFORM Personalised Risk assessment in febrile illness to Optimise Rela-life Management across the European Union. EU H2020 Project  Co-PI Radboudumc.

2012-2016           EUCLIDS European Childhood Life-threatening Infectious Disease Study . EU FP7  Investigator Radboudumc coordinator Dutch patient inclusion.