Madelon Maurice

Full Professor

Strategic program(s):

Biography

Strategic program(s):

Contact

mmaurice@umcutrecht.nl

Pure profile

Research groups

Cancer tissue organization, Cell-cell signaling, Organoid models, Mutational driver mechanisms, Targeted protein degradation

Research aim

We aim to 1) acquire a molecular understanding of how patient-derived mutations promote cancer development and progression, and 2) use our expertise and know-how in targeted protein degradation to develop improved cancer-targeting strategies.

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Recent publications

All publications

E3 ligases RNF43 and ZNRF3 display differential specificity for endocytosis of Frizzled receptors Jeroen M Bugter, Peter van Kerkhof, Ingrid Jordens, Eline Janssen, Thi Tran Ngoc Minh, Daniel Iglesias van Montfort, Cara Jamieson, Madelon M Maurice
Life Science Alliance, 2024, vol. 7

Intestinal Paneth cell differentiation relies on asymmetric regulation of Wnt signaling by Daam1/2 Gabriele Colozza, Heetak Lee, Alessandra Merenda, Szu Hsien Sam Wu, Andrea Català-Bordes, Tomasz W. Radaszkiewicz, Ingrid Jordens, Ji Hyun Lee, Aileen Diane Bamford, Fiona Farnhammer, Teck Yew Low, Madelon M. Maurice, Vítězslav Bryja, Jihoon Kim, Bon Kyoung Koo
Science advances, 2023, vol. 9

RSPO3 Furin domain-conjugated liposomes for selective drug delivery to LGR5-high cells Peter van Kerkhof, Tomica Kralj, Francesca Spanevello, Louis van Bloois, Ingrid Jordens, Jelte van der Vaart, Cara Jamieson, Alessandra Merenda, Enrico Mastrobattista, Madelon M. Maurice
Journal of Controlled Release, 2023, vol. 356, p.72-83

A novel antifolate suppresses growth of FPGS-deficient cells and overcomes methotrexate resistance Felix van der Krift, Dick W. Zijlmans, Rhythm Shukla, Ali Javed, Panagiotis I. Koukos, Laura L.E. Schwarz, Elpetra P.M. Timmermans-Sprang, Peter E.M. Maas, Digvijay Gahtory, Maurits van den Nieuwboer, Jan A. Mol, Ger J. Strous, Alexandre M.J.J. Bonvin, Mario van der Stelt, Edwin J.A. Veldhuizen, Markus Weingarth, Michiel Vermeulen, Judith Klumperman, Madelon M. Maurice
Life Science Alliance, 2023, vol. 6, p.1-19

AXIN1 bi-allelic variants disrupting the C-terminal DIX domain cause craniometadiaphyseal osteosclerosis with hip dysplasia Paulien Terhal, Anton J Venhuizen, Davor Lessel, Wen-Hann Tan, Abdulrahman Alswaid, Regina Grün, Hamad I Alzaidan, Simon von Kroge, Nada Ragab, Maja Hempel, Christian Kubisch, Eduardo Novais, Alba Cristobal, Kornelia Tripolszki, Peter Bauer, Björn Fischer-Zirnsak, Rutger A J Nievelstein, Atty van Dijk, Peter Nikkels, Ralf Oheim, Heidi Hahn, Aida Bertoli-Avella, Madelon M Maurice, Uwe Kornak
American Journal of Human Genetics, 2023, vol. 110, p.1470-1481

Mechanical forces directing intestinal form and function Ronja M. Houtekamer, Mirjam C. van der Net, Madelon M. Maurice, Martijn Gloerich
Current Biology, 2022, vol. 32, p.R791-R805