Madelon Maurice

Full Professor

Strategic program(s):

Biography

Strategic program(s):

Contact

mmaurice@umcutrecht.nl

Pure profile

Research groups

Cancer tissue organization, Cell-cell signaling, Organoid models, Mutational driver mechanisms, Targeted protein degradation

Research aim

We aim to 1) acquire a molecular understanding of how patient-derived mutations promote cancer development and progression, and 2) use our expertise and know-how in targeted protein degradation to develop improved cancer-targeting strategies.

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Recent publications

All publications

BRAF^V600E augments WNT signaling in colorectal cancer via aberrant DNA methylation Layla El Bouazzaoui, Jeroen M. Bugter, Emre Küçükköse, André Verheem, Jasmin B. Post, Nicola Fenderico, Inne H.M. Borel Rinkes, Hugo J.G. Snippert, Madelon M. Maurice, Onno Kranenburg
iScience, 2025, vol. 28

BRAF^V600E maintains the CpG island methylator phenotype, and DNA methylation of PRC2 targets genes in colon cancer Layla El Bouazzaoui, Jeroen M. Bugter, Emre Küçükköse, André Verheem, Jasmin B. Post, Nicola Fenderico, Inne H.M. Borel Rinkes, Hugo J.G. Snippert, Madelon M. Maurice, Onno Kranenburg
iScience, 2025, vol. 28

Resistance to MAPK Pathway Inhibition in BRAF-V600E Mutant Colorectal Cancer Can Be Overcome with Insulin Receptor/Insulin-like Growth Factor-1 Receptor Inhibitors Layla El Bouazzaoui, Daniëlle A.E. Raats, André Verheem, Inne H.M.Borel Rinkes, Hugo J.G. Snippert, Madelon M. Maurice, Onno Kranenburg
Organoids, 2025, vol. 4

Mechanistic insights into Wnt–β-catenin pathway activation and signal transduction Madelon M. Maurice, Stephane Angers
Nature reviews molecular cell biology, 2025, vol. 26, p.371-388

Correction Michaela Reissland, Oliver Hartmann, Saskia Tauch, Jeroen M. Bugter, Cristian Prieto-Garcia, Clemens Schulte, Sinah Loebbert, Daniel Solvie, Eliya Bitman-Lotan, Ashwin Narain, Anne Claire Jacomin, Christina Schuelein-Voelk, Carmina T. Fuss, Nikolett Pahor, Carsten Ade, Viktoria Buck, Michael Potente, Vivian Li, Gerti Beliu, Armin Wiegering, Tom Grossmann, Martin Eilers, Elmar Wolf, Hans Maric, Mathias Rosenfeldt, Madelon M. Maurice, Ivan Dikic, Peter Gallant, Amir Orian, Markus E. Diefenbacher
Oncogene, 2025, vol. 44

USP10 drives cancer stemness and enables super-competitor signalling in colorectal cancer Michaela Reissland, Oliver Hartmann, Saskia Tauch, Jeroen M. Bugter, Cristian Prieto-Garcia, Clemens Schulte, Sinah Loebbert, Daniel Solvie, Eliya Bitman-Lotan, Ashwin Narain, Anne Claire Jacomin, Christina Schuelein-Voelk, Carmina T. Fuss, Nikolett Pahor, Carsten Ade, Viktoria Buck, Michael Potente, Vivian Li, Gerti Beliu, Armin Wiegering, Tom Grossmann, Martin Eilers, Elmar Wolf, Hans Maric, Mathias Rosenfeldt, Madelon M. Maurice, Ivan Dikic, Peter Gallant, Amir Orian, Markus E. Diefenbacher
Oncogene, 2024, vol. 43, p.3645-3659

Fellowships & Awards

UMCU-TKI grant 2023

KWF-TKI grant 2023

External positions

Chair of Scientific Advisory Board of Laigo Bio - Scientific advisory activities - Laigo Bio BV

Scientific advisor - Scientific advisory activities - Laigo Bio BV

Patent holder on inventive technology licensed to Laigo Bio BV - N/A - Laigo Bio BV

Grant Support ArgoBio - Ja - Grant support bij ArgoBio

Co-founder en shareholder bij Laigon Bio - Ja - Laigo Bio

Lid van research management committee bij Oncode Institute - Ja - Oncode Institute

Member of Research Council KWF - Ja - KWF