Madelon Maurice

Full Professor

Strategic program(s):

Biography

Strategic program(s):

Contact

mmaurice@umcutrecht.nl

Pure profile

Research groups

Cancer tissue organization, Cell-cell signaling, Organoid models, Mutational driver mechanisms, Targeted protein degradation

Research aim

We aim to 1) acquire a molecular understanding of how patient-derived mutations promote cancer development and progression, and 2) use our expertise and know-how in targeted protein degradation to develop improved cancer-targeting strategies.

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Recent publications

All publications

A peptide strategy for inhibiting different protein aggregation pathways Tommaso Garfagnini, Luca Ferrari, Margreet B Koopman, Francoise A Dekker, Sem Halters, Eline Van Kappel, Guy Mayer, Shachar Bressler, Madelon M Maurice, Stefan G D Rudiger, Assaf Friedler
Chemistry-A European Journal, 2024, vol. 30

E3 ligases RNF43 and ZNRF3 display differential specificity for endocytosis of Frizzled receptors Jeroen M Bugter, Peter van Kerkhof, Ingrid Jordens, Eline Janssen, Thi Tran Ngoc Minh, Daniel Iglesias van Montfort, Cara Jamieson, Madelon M Maurice
Life Science Alliance, 2024, vol. 7

USP10 drives cancer stemness and enables super-competitor signalling in colorectal cancer Michaela Reissland, Oliver Hartmann, Saskia Tauch, Jeroen M. Bugter, Cristian Prieto-Garcia, Clemens Schulte, Sinah Loebbert, Daniel Solvie, Eliya Bitman-Lotan, Ashwin Narain, Anne Claire Jacomin, Christina Schuelein-Voelk, Carmina T. Fuss, Nikolett Pahor, Carsten Ade, Viktoria Buck, Michael Potente, Vivian Li, Gerti Beliu, Armin Wiegering, Tom Grossmann, Martin Eilers, Elmar Wolf, Hans Maric, Mathias Rosenfeldt, Madelon M. Maurice, Ivan Dikic, Peter Gallant, Amir Orian, Markus E. Diefenbacher
Oncogene, 2024, vol. 43, p.3645-3659

Intestinal Paneth cell differentiation relies on asymmetric regulation of Wnt signaling by Daam1/2 Gabriele Colozza, Heetak Lee, Alessandra Merenda, Szu Hsien Sam Wu, Andrea Català-Bordes, Tomasz W. Radaszkiewicz, Ingrid Jordens, Ji Hyun Lee, Aileen Diane Bamford, Fiona Farnhammer, Teck Yew Low, Madelon M. Maurice, Vítězslav Bryja, Jihoon Kim, Bon Kyoung Koo
Science advances, 2023, vol. 9

RSPO3 Furin domain-conjugated liposomes for selective drug delivery to LGR5-high cells Peter van Kerkhof, Tomica Kralj, Francesca Spanevello, Louis van Bloois, Ingrid Jordens, Jelte van der Vaart, Cara Jamieson, Alessandra Merenda, Enrico Mastrobattista, Madelon M. Maurice
Journal of Controlled Release, 2023, vol. 356, p.72-83

A novel antifolate suppresses growth of FPGS-deficient cells and overcomes methotrexate resistance Felix van der Krift, Dick W. Zijlmans, Rhythm Shukla, Ali Javed, Panagiotis I. Koukos, Laura L.E. Schwarz, Elpetra P.M. Timmermans-Sprang, Peter E.M. Maas, Digvijay Gahtory, Maurits van den Nieuwboer, Jan A. Mol, Ger J. Strous, Alexandre M.J.J. Bonvin, Mario van der Stelt, Edwin J.A. Veldhuizen, Markus Weingarth, Michiel Vermeulen, Judith Klumperman, Madelon M. Maurice
Life Science Alliance, 2023, vol. 6, p.1-19

Fellowships & Awards

UMCU-TKI grant 2023

KWF-TKI grant 2023

External positions

Chair of Scientific Advisory Board of Laigo Bio - Scientific advisory activities - Laigo Bio BV

Scientific advisor - Scientific advisory activities - Laigo Bio BV

Patent holder on inventive technology licensed to Laigo Bio BV - N/A - Laigo Bio BV

Grant Support ArgoBio - Ja - Grant support bij ArgoBio

Co-founder en shareholder bij Laigon Bio - Ja - Laigo Bio

Lid van research management committee bij Oncode Institute - Ja - Oncode Institute

Member of Research Council KWF - Ja - KWF