Researchers Simon Mastbergen

Simon Mastbergen

Associate Professor

Strategic program(s):

Biography

Dr. Simon C. Mastbergen is an associate professor and director of research at the department Rheumatology & Clinical Immunology of the University Medical Center Utrecht, The Netherlands. He studied Medical Biology and obtained his MSc in 1998. In 2005 he obtained his PhD which was focused on the role of COX-2 in osteoarthritis. He has a strong interest in translational rheumatology research with a focus on tissue-regeneration in joint diseases, especially osteoarthritis, though not limited to. Central theme of his research is modulation of cartilage, synovium, and bone to prevent and when possible, cure joint damage. Within this theme he is involved in several research lines including “Joint distraction in treatment of severe osteoarthritis", “Causes of development and progression of osteoarthritis”, and “DMOADS in treatment of osteoarthritis” amongst other. Within these research lines he pushes for innovation and translation to the clinic.

Strategic program(s):

Contact

smastber@umcutrecht.nl

Pure profile

Research groups

Rheumatology & clinical immunology

Research aim

To improve clinical practice by optimizing diagnosis, prognosis and treatment of rheumatic and immune-mediated and immune-deficient inflammatory diseases

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Knee joint preserving treatments

Research aim

The main goal of our research group is to develop and test joint preserving treatments for the knee joint, for pathology ranging from cartilage lesions to endstage osteoarthritis

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Recent publications

All publications

Dextran-tryamine hydrogel maintains position and integrity under simulated loading in a human cadaver knee model G. S. van der Weiden, S. C. Mastbergen, S. K. Both, M. Karperien, F. P. Lafeber, N. van Egmond, R. J.H. Custers
Osteoarthritis and Cartilage Open, 2024, vol. 6

The catabolic-to-anabolic shift seen in the canine osteoarthritic cartilage treated with knee joint distraction occurs after the distraction period M. Teunissen, B. P. Meij, L. Snel, K. Coeleveld, J. Popov-Celeketic, I. S. Ludwig, F. Broere, F. P.J.G. Lafeber, M. A. Tryfonidou, S. C. Mastbergen
Journal of Orthopaedic Translation, 2023, vol. 38, p.44-55

Machine-learning predicted and actual 2-year structural progression in the IMI-APPROACH cohort Mylène P. Jansen, Wolfgang Wirth, Jaume Bacardit, Eefje M. van Helvoort, Anne C.A. Marijnissen, Margreet Kloppenburg, Francisco J. Blanco, Ida K. Haugen, Francis Berenbaum, Cristoph H. Ladel, Marieke Loef, Floris P.J.G. Lafeber, Paco M. Welsing, Simon C. Mastbergen, Frank W. Roemer
Quantitative Imaging in Medicine and Surgery, 2023, vol. 13, p.3298-3306

Structural changes after ankle joint distraction in haemophilic arthropathy Eline D P van Bergen, Simon C Mastbergen, Floris P J G Lafeber, Anne-Christine Bay-Jensen, Sofie F Madsen, Helena Port, Wouter Foppen, Roger E G Schutgens, Mylène P Jansen, Lize F D van Vulpen
Haemophilia, 2023, vol. 29, p.874-882

Subclinical synovial proliferation in patients with severe haemophilia A Eline D.P. van Bergen, Flora H.P. van Leeuwen, Wouter Foppen, Merel A. Timmer, Roger E.G. Schutgens, Simon C. Mastbergen, Floris P.J.G. Lafeber, Pim A. de Jong, Kathelijn Fischer, Lize F.D. van Vulpen
Haemophilia, 2023, vol. 29, p.1580-1588

Identifying multivariate disease trajectories and potential phenotypes of early knee osteoarthritis in the CHECK cohort Sara Altamirano, Mylène P. Jansen, Daniel L. Oberski, Marinus J.C. Eijkemans, Simon C. Mastbergen, Floris P.J.G. Lafeber, Willem E. van Spil, Paco M.J. Welsing
PLoS ONE, 2023, vol. 18