Profile photo Marlies de Graaf

Marlies de Graaf

Assistant Professor - medical

Strategic program(s):

Biography

Marlies de Graaf is a dermatologist and clinical scientist at the University Medical Center Utrecht (UMCU), where she leads the Pediatric Dermatology Department at the Wilhelmina Children’s Hospital. She also heads the National Expertise Center for Atopic Dermatitis in Children. Her research mission is to improve personalized care for children with severe AD thereby improving their quality of life. By learning from adult care, but focusing on the uniqueness of children, she tries to answer questions that arise in early interventions, such as the safety of treatment for children and the possibility of modifying the immune system. For this, she has built a unique cohort with biomaterial from young children with AD.

Marlies completed her medical training at Maastricht University (2000-2006) and her dermatology residency and PhD (2013) at UMC Utrecht. In order to further develop her research qualities, Marlies was appointed as a clinical scientist (2025). Her research focuses on atopic dermatitis (AD) and related atopic comorbidities in children and adults. She is co-PI of the BioDay Registry, a national registry that collects real-world data on systemic treatments for AD. She is PI of clinical trials and supervises multiple PhD candidates and junior researchers. Her work integrates clinical data with immunological profiling, enabling personalized treatment strategies and life-course research. She has also pioneered non-invasive sampling methods to facilitate translational research studies in young children.

Marlies is an active member of the Dutch Society of Dermatology and Venereology’s Pediatric Dermatology Expertise Group, the advisory board Dutch Patient Society for Atopic Dermatitis (VMCE) and serves on the board of the European Society of Pediatric Dermatology.

Research groups

Atopic dermatitis

Research aim

By combining clinical and translational research the goal of our research is to improve personalized treatment of adult and pediatric atopic dermatitis patients. The ultimate goal is to achieve disease modification and prevent atopic comorbidities.

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Recent publications

Long-Term Ocular Outcomes of Dupilumab in Atopic Dermatitis Nienke Veldhuis, Roselie E Achten, Chantal M van Luijk, Marlot M van der Wal, Constance F den Hartog Jager, Nicolaas P A Zuithoff, Mohsin El Amrani, Edward F Knol, Femke van Wijk, Marlies de Graaf, Inge M Haeck, Mor M Dickman, Marjolein S de Bruin-Weller
Clinical and Translational Allergy, 2026, vol. 16
Sustained efficacy of dupilumab in paediatric patients with moderate-to-severe atopic dermatitis over 1 year Elaine C Siegfried, Eulalia Baselga, Marlies de Graaf, Eric L Simpson, Mark Boguniewicz, Carsten Flohr, Lawrence F Eichenfield, Amy S Paller, Michele Ramien, Xing-Hua Gao, Jiyoung Ahn, Korey Capozza, Yonghao Ma, Lauren Bates, Ana B Rossi
British Journal of Dermatology, 2026, vol. 195, p.677-680
Current treatment landscape of atopic dermatitis focusing on real-world evidence of dupilumab treatment Celeste M Boesjes, Lian F van der Gang, Roselie E Achten, Daphne S Bakker, Lisa P van der Rijst, Coco C Dekkers, Femke van Wijk, Inge M Haeck, Marjolein S de Bruin-Weller, Marlies de Graaf
Expert Opinion on Biological Therapy, 2025, vol. 25, p.1171-1192
Reading the palms Florence Vroman, Marlies de Graaf
JEADV : journal of the European Academy of Dermatology and Venereology, 2025, vol. 39, p.2028-2029
Systemic Treatments in Moderate-to-Severe Atopic Dermatitis in Pediatric Patients up to 12 Years of Age Amy S. Paller, Danielle Marcoux, Michele Ramien, Eulalia Baselga, Vania Oliveira Carvalho, Ledit R.F. Ardusso, Marlies de Graaf, Suzanne Pasmans, Mirna Toledo-Bahena, Cory Rubin, Joel C. Joyce, Lara Wine Lee, Rajan Gupta, Bryan Adams, Marius Ardeleanu, Annie Zhang
American Journal of Clinical Dermatology, 2025, vol. 26, p.1031-1043
Topical Steroid Withdrawal Florence Vroman, Charlotte S Schimmel, Lisa P Van der Rijst, Marlies De Graaf, Marjolein De Bruin-Weller, Patrick M J H Kemperman, Dirk Jan Hijnen, Inge M Haeck
Acta Dermato-Venereologica, 2025, vol. 105