Maria Rodriguez Colman

Associate Professor

Strategic program(s):

Contact

mrodrigu@umcutrecht.nl

Pure profile

Research groups

Metabolism, Stem cells and Cancer

Research aim

Our overarching goal is to gain deep molecular understanding of cancer and stem cell metabolism to enable the development of novel therapies to treat diseases with a particular interest in cancer.

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Recent publications

All publications

FOXO transcription factors as mediators of stress adaptation Maria J. Rodriguez-Colman, Tobias B. Dansen, Boudewijn M.T. Burgering
Nature reviews molecular cell biology, 2024, vol. 25, p.46-64

Engineered human hepatocyte organoids enable CRISPR-based target discovery and drug screening for steatosis Delilah Hendriks, Jos F. Brouwers, Karien Hamer, Maarten H. Geurts, Léa Luciana, Simone Massalini, Carmen López-Iglesias, Peter J. Peters, Maria J. Rodríguez-Colman, Susana Chuva de Sousa Lopes, Benedetta Artegiani, Hans Clevers
Nature Biotechnology, 2023, vol. 41, p.1567-1581

Rewiring glucose metabolism improves 5-FU efficacy in p53-deficient/KRAS ^G12D glycolytic colorectal tumors Marlies C. Ludikhuize, Sira Gevers, Nguyen T.B. Nguyen, Maaike Meerlo, S. Khadijeh Shafiei Roudbari, M. Can Gulersonmez, Edwin C.A. Stigter, Jarno Drost, Hans Clevers, Boudewijn M.T. Burgering, Maria J. Rodríguez Colman
Communications biology, 2022, vol. 5

Protocol to profile the bioenergetics of organoids using Seahorse Marlies C. Ludikhuize, Maaike Meerlo, Boudewijn M.T. Burgering, Maria J. Rodríguez Colman
STAR protocols, 2021, vol. 2

A FOXO-dependent replication checkpoint restricts proliferation of damaged cells Marten Hornsveld, Femke M. Feringa, Lenno Krenning, Jeroen van den Berg, Lydia M.M. Smits, Nguyen B.T. Nguyen, Maria J. Rodríguez-Colman, Tobias B. Dansen, René H. Medema, Boudewijn M.T. Burgering
Cell Reports, 2021, vol. 34

Mitochondria Define Intestinal Stem Cell Differentiation Downstream of a FOXO/Notch Axis Marlies C. Ludikhuize, Maaike Meerlo, Marc Pages Gallego, Despina Xanthakis, Mar Burgaya Julià, Nguyen T.B. Nguyen, Eline C. Brombacher, Nalan Liv, Madelon M. Maurice, Ji hye Paik, Boudewijn M.T. Burgering, Maria J. Rodriguez Colman
Cell Metabolism, 2020, vol. 32, p.889-900.e7