Profile photo Marc Bonten

Marc Bonten

Full Professor

Strategic program(s):

Biography

Marc Bonten earned his MD (1991) and PhD (“the role of colonization of the upper intestinal tract in the pathogenesis of ventilator-associated pneumonia, 1994) at the Maastricht University Medical School, the Netherlands. He registered as internist in 2000, as infectious disease specialist in 2002, as clinical microbiologist in 2008 and as Epidemiologist (B) in 2025, all at the University Medical Center Utrecht, the Netherlands. . Since 2003 he is professor of molecular epidemiology of infectious diseases. He has been a principal investigator in many large scale epidemiologic studies and investigator-initiated randomized trials of prevention and treatment of infectious diseases. His experience covers the full range of epidemiologic study designs including clinical trials, cohorts, case-control studies and mathematical modelling to study antibiotic resistance and infection prevention. Specific research interests include the epidemiology of antibiotic-resistant bacteria such as VRE, MRSA and MDR Enterobacteriaceae, selective decontamination in intensive care unit patients, prevention of ventilator-associated pneumonia, treatment of community-acquired pneumonia, and prevention and treatment of community-acquired pneumonia, including COVID-19.

Vice-dean of Education and Director Education Center at UMC Utrecht (July 2025-)

Coordinator of the H2020-funded projects ECRAID-Base (March 2021-), ECRAID-Prime (Dec 2021-) and Chief Executive Officer of the ECRAID foundation (Jan 2022-)

Member of the Koninklijke Nederlandse Academie voor Wetenschappen en Kunsten (Royal Academy of Sciences and Art) (April 2021-)

Research groups

Epidemiology and clinical trials in infectious diseases

Research aim

To improve prevention, diagnosis and treatment of infectious diseases and to establish an international research infrastructure for a rapid scientific response in the face of a new infectious disease threat.

Go to group

Epidemiology of sepsis & inflammation in critically ill patients

Research aim

We design and conduct clinical epidemiological research focused on risk stratification, early diagnosis, and novel treatment of critically ill patients with severe infections.

Go to group

Recent publications

Publisher Correction Derek C. Angus, Djillali Annane, Balasubramanian Venkatesh, Scott Berry, Steven A. Webb, Srinivas Murthy, Ryan Zarychanski, Elizabeth Whittaker, Alicia A.C. Waite, Frank L. van de Veerdonk, Andrew Ustianowski, Anne M. Turner, Alexis F. Turgeon, Paul A. Tambyah, Vanessa Singh, Manu Shankar-Hari, Christopher Seymour, Christina T. Saunders, Marlene S. Santos, Hiroki Saito, Kathryn M. Rowan, Luis Felipe Reyes, Padmanabhan Ramnarayan, Svenja Peters, Jane C. Parker, Rachael L. Parke, Alistair D. Nichol, Paul R. Mouncey, Susan C. Morpeth, Bryan J. McVerry, Zoe McQuilten, Shay McGuinness, Anna McGlothlin, Daniel F. McAuley, Colin J. McArthur, John C. Marshall, Edward Litton, Roger J. Lewis, Patrick R. Lawler, Francois Lamontagne, Peter S. Kruger, Devachandran Jayakumar, Nao Ichihara, David T. Huang, Christopher Horvat, Leanne Hays, Madiha Hashmi, Rashan Haniffa, Lennie Derde, Marc Bonten,
Intensive Care Medicine, 2025, vol. 51, p.1415
Hurdles for the Delivery of Multinational Randomized Clinical Trials Denise van Hout, Paul Mouncey, David Harrison, Marc Bonten, Lennie Derde, Derek C Angus, Aisha Anjum, Djillali Annane, Janis Best-Lane, Frank Brunkhorst, Maurizio Cecconi, Stephan Ehrmann, Anthony Gordon, Leanne Marie Hays, Esmee Kester, Niamh Mahon, Colin McArthur, Alistair Nichol, Svenja Peters, Sara Pugliese, Kathryn Rowan, Julian Torre-Cisneros, Sebastian Weis,
JAMA network open, 2025, vol. 8
Pathogen-specific host response in critically ill patients with blood stream infections Joe M Butler, Hessel Peters-Sengers, Tom D Y Reijnders, Tjitske S R van Engelen, Fabrice Uhel, Lonneke A van Vught, Marcus J Schultz, Pierre-François Laterre, Bruno François, Miguel Sánchez-García, Eleuterio Lombardo, Timothy E Sweeney, Marc J Bonten, W Joost Wiersinga, Dayle Sampson, Leo C Bolero, Thomas Yager, Olaf L Cremer, Brendon P Scicluna, Tom van der Poll
EBioMedicine, 2025, vol. 117
Impact of co-infection with SARS-CoV-2 and other respiratory viruses on illness Marieke L.A. de Hoog, Emma S.E.M. Hauser - van Westrhenen, Angelique M.A.M. Winkel, Menno D. de Jong, Marlies A. van Houten, Steven F.L. van Lelyveld, Dirk Eggink, Sjoerd Euser, Liesbeth Duijts, Joanne G. Wildenbeest, Rob Schuurman, Janneke H.H.M. van de Wijgert, Margareta Ieven, Katherine Loens, Alike W. van der Velden, Marc J.M. Bonten, Herman Goossens, Patricia C.J.L. Bruijning-Verhagen
Journal of Infection, 2025, vol. 90
Behandelduur pneumonie bepalen met biomarker Ruud Duijkers, Marc J M Bonten, Wim G Boersma
Nederlands Tijdschrift voor Geneeskunde, 2025, vol. 169
Effect of hydrocortisone on mortality in patients with severe community-acquired pneumonia , Derek C Angus, Marc Bonten, LP Derde
Intensive Care Medicine, 2025, vol. 51, p.665-680

Fellowships & Awards

He is a VICI laureate (2006) from the Dutch Science Association, Principal Investigator of the CAPiTA study, coordinator of the EU-funded project R-GNOSIS, scientific coordinator of the IMI-funded consortiums COMBACTE-NET, COMBACTE-CARE, COMBACTE-MAGNET and PrimaVeRa. He is member of the International Trial Steering Committee of the REMAP-CAP study and the SNAP-study, and coordinator of ECRAID-Base and ECRAID-Prime.  

In 2015 he received the ESCMID 2015 Award for Excellence in Clinical Microbiology and Infectious Diseases.

In 2017 he received a honorary fellowship of the Royal College of Physicians of Ireland, and was awarded the ESCMID fellowship.

In 2021 he was elected member of the Koninklijke Nederlandse Academi voor Wetenschappen.

External positions

CEO - Clinical trials - Ecraid

Consultancy, assisteren bij het identificeren van geschikte studie lokaties voor fase3 studie - Werkzaamheden in kader van mijn rol als CEO Ecraid - Janssen Research

Via Ecraid, identificeren van geschikte klinieken voor deelname aan wetenschappelijk onderzoek - CEO van Ecraid - Spherecytes

Wetenschappelijk advies - Expertisegebied - Pherecydes Pharma

Scientific Advisor Ensovibep - Expertise - Novartis

Member Scientific Advisory Board - Scientific evaluation of GRADP-funded research projects - GARDP

Independent Data Monitoring Committee of the PSK008 and PSK009 studies on pneumococcal vaccination. - expertise - Sanofi Pasteur

Chair of international study steering committee E.mbrace study - Expertise area - Janssen Vaccines and Prevention BV