Profile photo Lennie Derde

Lennie Derde

Assistant Professor - medical

Strategic program(s):

Biography

Lennie is an ICU consultant in the UMC Utrecht, with a background in infectious diseases and epidemiology. She co-leads (with Olaf Cremer) the "epidemiology of sepsis and inflammation" research group. Her research focuses on clinical trials in critically ill patients, especially those with sepsis and severe infections, to improve trial methodology/design, delivery, and analysis. Lennie is the European PI and immediate past global chair of REMAP-CAP, and a co-applicant and work package leader on EU-funded projects like RECOVER and ECRAID-Base, leads the ZonMw funded IMPRINT consortium and is co-applicant on several international collaborative grants. She is a member of the Steering Committee for the Surviving Sepsis Campaign and the ISAB of Sepsis Canada.

Research groups

Epidemiology and clinical trials in infectious diseases

Research aim

To improve prevention, diagnosis and treatment of infectious diseases and to establish an international research infrastructure for a rapid scientific response in the face of a new infectious disease threat.

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Epidemiology of sepsis & inflammation in critically ill patients

Research aim

We design and conduct clinical epidemiological research focused on risk stratification, early diagnosis, and novel treatment of critically ill patients with severe infections.

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Recent publications

Platform Clinical Trials for the Efficient Evaluation of Multiple Treatments Steve A Webb, Lennie P G Derde
JAMA, 2025, vol. 333, p.1166-1167
Longitudinal assessment of immunoglobulin response and disease progression in critically ill patients with community acquired pneumonia Emma Rademaker, Lisette M Vernooij, Tom van der Poll, Marc J M Bonten, Helen Leavis, Olaf L Cremer, Lennie P G Derde
Critical care (London, England), 2024, vol. 28
The Rise of Adaptive Platform Trials in Critical Care , LP Derde
American journal of respiratory and critical care medicine, 2024, vol. 209, p.491-496
Environmental sustainability in intensive care Jan J De Waele, Nicole Hunfeld, Heather Baid, Ricard Ferrer, Katerina Iliopoulou, Ana-Maria Ioan, Marc Leone, Marlies Ostermann, Gaetano Scaramuzzo, Maria Theodorakopoulou, Hugo Touw, Giuseppe Citerio, Lennie P G Derde, Katia Donadello, Nicole P Juffermans, Laura Galarza, Giacomo Grasselli, Salvatore Maurizio Maggiore, Ignacio Martin-Loeches, Joel Alexandre, Maurizio Cecconi, Elie Azoulay
Intensive Care Medicine, 2024, vol. 50, p.1729-1739
The impact of the massive open online course C19_SPACE during the COVID-19 pandemic on clinical knowledge enhancement Maurizio Cecconi, Anita Barth, Gergő József Szőllősi, Gizella Melania Istrate, Joel Alexandre, Frantisek Duska, Stefan J Schaller, Carole Boulanger, Johannes Mellinghoff, Peter Waldauf, Armand R J Girbes, Lennie Derde, Jan J De Waele, Elie Azoulay, Jozef Kesecioglu
Intensive Care Medicine, 2024, vol. 50, p.1841-1849
Sodium-Glucose Cotransporter 2 Therapy for Acute Organ Dysfunction in Critically Ill Patients Hernando Gómez, Lennie P.G. Derde
JAMA, 2024, vol. 332, p.377-379