Lennie Derde

Assistant Professor - medical

Strategic program(s):

Biography

Lennie is an ICU consultant in the UMC Utrecht, with a background in infectious diseases and epidemiology. She co-leads (with Olaf Cremer) the "epidemiology of sepsis and inflammation" research group. Her research focuses on clinical trials in critically ill patients, especially those with sepsis and severe infections, to improve trial methodology/design, delivery, and analysis. Lennie is the European PI and immediate past global chair of REMAP-CAP, and a co-applicant and work package leader on EU-funded projects like RECOVER and ECRAID-Base, leads the ZonMw funded IMPRINT consortium and is co-applicant on several international collaborative grants. She is a member of the Steering Committee for the Surviving Sepsis Campaign and the ISAB of Sepsis Canada.

Strategic program(s):

Contact

lderde@umcutrecht.nl

Pure profile

Research groups

Epidemiology and clinical trials in infectious diseases

Research aim

To improve prevention, diagnosis and treatment of infectious diseases and to establish an international research infrastructure for a rapid scientific response in the face of a new infectious disease threat.

Go to group

Epidemiology of sepsis & inflammation in critically ill patients

Research aim

We design and conduct clinical epidemiological research focused on risk stratification, early diagnosis, and novel treatment of critically ill patients with severe infections.

Go to group

Recent publications

All publications

11 - Trials Simon Finfer, Lennie P.G. Derde, Naomi E. Hammond, Anthony Delaney
2026, p.89-98

Temporal robustness of biomarker-based classification algorithms for sepsis Emma Rademaker, Rombout B E van Amstel, Said El Bouhaddani, Marc J M Bonten, Lennie P G Derde, Lonneke van Vught, Tom van der Poll, Lieuwe D J Bos, Harm-Jan de Grooth, Olaf L Cremer
Intensive Care Medicine, 2025, vol. 52, p.22-30

Community-acquired pneumonia Luis Felipe Reyes, Andrew Conway Morris, Cristian Serrano-Mayorga, Lennie P G Derde, Robert P Dickson, Ignacio Martin-Loeches
Lancet (London, England), 2025, vol. 406, p.2371-2388

The immunology of sepsis Matthijs Kox, Michael Bauer, Lieuwe D J Bos, Hjalmar Bouma, Thierry Calandra, Carolyn S Calfee, Benjamin G Chousterman, Lennie P G Derde, Evangelos J Giamarellos-Bourboulis, Hernando Gómez, Mihai G Netea, Marlies Ostermann, Tom van der Poll, Brendon P Scicluna, Christopher Seymour, Manu Shankar-Hari, Nathan Shapiro, Mervyn Singer, Fabienne Venet, Alexander P J Vlaar, Lonneke A van Vught, Sebastian Weis, W Joost Wiersinga, Peter Pickkers
Nature Reviews. Nephrology, 2025, vol. 22, p.30-49

Judicious use of critical care resources by predicting the need for routine ICU admission following esophagectomy Nikki de Mul, Lisette M Vernooij, Nynke C J van Haastregt, Eline M de Groot, Willem-Jan M Schellekens, Lennie P G Derde, Jelle P Ruurda, Olaf L Cremer
Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus, 2025, vol. 38

Immunobiological effects of tocilizumab across respiratory subphenotypes in COVID-19 ARDS Emma Rademaker, Daan F L Filippini, Jelle L G Haitsma Mulier, Marleen A Slim, Rombout B E van Amstel, Sivasubramanium V Bhavani, Nicole P Juffermans, Harm-Jan S de Grooth, Lennie P G Derde, Olaf L Cremer, Lieuwe D J Bos,
Intensive Care Medicine Experimental, 2025, vol. 13

External positions

CEO - Chief Executive Officer - Ecraid

lid Steering Committee en lid Guidelines (als ESICM Vice-chair) - Maken internationale sepsis richtlijn, en als Steering Committee strategische richting bepalen. - Surviving Sepsis Campaign

Lid International Scientific Advisory Board - Advies geven aan deze not-for-profit organisatie ter verbetering uitkomsten van sepsis - Sepsis Canada