Profile photo Lennie Derde

Lennie Derde

Assistant Professor - medical

Strategic program(s):

Biography

Lennie is an ICU consultant in the UMC Utrecht, with a background in infectious diseases and epidemiology. She co-leads (with Olaf Cremer) the "epidemiology of sepsis and inflammation" research group. Her research focuses on clinical trials in critically ill patients, especially those with sepsis and severe infections, to improve trial methodology/design, delivery, and analysis. Lennie is the European PI and immediate past global chair of REMAP-CAP, and a co-applicant and work package leader on EU-funded projects like RECOVER and ECRAID-Base, leads the ZonMw funded IMPRINT consortium and is co-applicant on several international collaborative grants. She is a member of the Steering Committee for the Surviving Sepsis Campaign and the ISAB of Sepsis Canada.

Research groups

Epidemiology and clinical trials in infectious diseases

Research aim

To improve prevention, diagnosis and treatment of infectious diseases and to establish an international research infrastructure for a rapid scientific response in the face of a new infectious disease threat.

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Epidemiology of sepsis & inflammation in critically ill patients

Research aim

We design and conduct clinical epidemiological research focused on risk stratification, early diagnosis, and novel treatment of critically ill patients with severe infections.

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Recent publications

Publisher Correction Derek C. Angus, Djillali Annane, Balasubramanian Venkatesh, Scott Berry, Steven A. Webb, Srinivas Murthy, Ryan Zarychanski, Elizabeth Whittaker, Alicia A.C. Waite, Frank L. van de Veerdonk, Andrew Ustianowski, Anne M. Turner, Alexis F. Turgeon, Paul A. Tambyah, Vanessa Singh, Manu Shankar-Hari, Christopher Seymour, Christina T. Saunders, Marlene S. Santos, Hiroki Saito, Kathryn M. Rowan, Luis Felipe Reyes, Padmanabhan Ramnarayan, Svenja Peters, Jane C. Parker, Rachael L. Parke, Alistair D. Nichol, Paul R. Mouncey, Susan C. Morpeth, Bryan J. McVerry, Zoe McQuilten, Shay McGuinness, Anna McGlothlin, Daniel F. McAuley, Colin J. McArthur, John C. Marshall, Edward Litton, Roger J. Lewis, Patrick R. Lawler, Francois Lamontagne, Peter S. Kruger, Devachandran Jayakumar, Nao Ichihara, David T. Huang, Christopher Horvat, Leanne Hays, Madiha Hashmi, Rashan Haniffa, Lennie Derde, Marc Bonten,
Intensive Care Medicine, 2025, vol. 51, p.1415
Hurdles for the Delivery of Multinational Randomized Clinical Trials Denise van Hout, Paul Mouncey, David Harrison, Marc Bonten, Lennie Derde, Derek C Angus, Aisha Anjum, Djillali Annane, Janis Best-Lane, Frank Brunkhorst, Maurizio Cecconi, Stephan Ehrmann, Anthony Gordon, Leanne Marie Hays, Esmee Kester, Niamh Mahon, Colin McArthur, Alistair Nichol, Svenja Peters, Sara Pugliese, Kathryn Rowan, Julian Torre-Cisneros, Sebastian Weis,
JAMA network open, 2025, vol. 8
Effect of hydrocortisone on mortality in patients with severe community-acquired pneumonia , Derek C Angus, Marc Bonten, LP Derde
Intensive Care Medicine, 2025, vol. 51, p.665-680
Immunomodulation for ARDS Emma Rademaker, Jelle L.G. Haitsma Mulier, Julia Drylewicz, Eveline M. Delemarre, Marleen A. Slim, Nicole P. Juffermans, Peter Pickkers, Marc J.M. Bonten, Olaf L. Cremer, Lennie P.G. Derde
CHEST Critical Care, 2025, vol. 3
Platform Clinical Trials for the Efficient Evaluation of Multiple Treatments Steve A Webb, Lennie P G Derde
JAMA, 2025, vol. 333, p.1166-1167
Longitudinal assessment of immunoglobulin response and disease progression in critically ill patients with community acquired pneumonia Emma Rademaker, Lisette M Vernooij, Tom van der Poll, Marc J M Bonten, Helen Leavis, Olaf L Cremer, Lennie P G Derde
Critical care (London, England), 2024, vol. 28