Helen Leavis

Associate Professor - medical

Strategic program(s):

Contact

hleavis@umcutrecht.nl

Pure profile

Research groups

Rheumatology & clinical immunology

Research aim

To improve clinical practice by optimizing diagnosis, prognosis and treatment of rheumatic and immune-mediated and immune-deficient inflammatory diseases

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Primary immunodeficiency

Research aim

To address unmet medical needs by detecting novel primary immunodeficiency, and improving clinical practice by optimizing diagnosis, prognosis and treatment of disease.

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Translational microbiomics

Research aim

Our aim is to translate human microbiome knowledge to improved diagnostic tests and clinical interventions by incorporating systems biology into clinical epidemiological studies, conducting mechanistic laboratory studies, and linking the two.

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Recent publications

All publications

The association of inflammatory markers with frailty and in-hospital mortality in older COVID-19 patients Estelle Tran Van Hoi, Brent Appelman, Simon Mooijaart, Virgil A S H Dalm, Harmke A Polinder Bos, Diana van Heemst, Bas F M van Raaij, Raymond Noordam, Anna Kuranova, Jacobien J Hoogerwerf, Geeske Peeters, Annemieke Smorenberg, , , , , KGM Moons, Maarten van Smeden, Helen Leavis
Experimental Gerontology, 2024, vol. 195

Longitudinal assessment of immunoglobulin response and disease progression in critically ill patients with community acquired pneumonia Emma Rademaker, Lisette M Vernooij, Tom van der Poll, Marc J M Bonten, Helen Leavis, Olaf L Cremer, Lennie P G Derde
Critical care (London, England), 2024, vol. 28

Pulmonary Computed Tomography Screening Frequency in Primary Antibody Deficiency Bas M Smits, Sharisa L Boland, Marjolein E Hol, Rana Dandis, Helen Leavis, Pim A de Jong, Sabine M P J Prevaes, Firdaus A A Mohamed Hoesein, Joris M van Montfrans, Pauline M Ellerbroek
Journal of Allergy and Clinical Immunology: In Practice, 2024, vol. 12, p.1037-1048.e3

Comprehensive reanalysis for CNVs in ES data from unsolved rare disease cases results in new diagnoses German Demidov, Burcu Yaldiz, José Garcia-Pelaez, Elke de Boer, Nika Schuermans, Liedewei Van de Vondel, Ida Paramonov, Lennart F. Johansson, Francesco Musacchia, Elisa Benetti, Gemma Bullich, Karolis Sablauskas, Sergi Beltran, Christian Gilissen, Alexander Hoischen, Stephan Ossowski, Richarda de Voer, Katja Lohmann, Carla Oliveira, Ana Topf, Lisenka E.L.M. Vissers, Kristina Zguro, Federico Zara, Ioannis Zaganas, Vicente A. Yépez, Brunhilde Wirth, David Webb, Hannah Verdin, Erika Van Nieuwenhove, Joris van Montfrans, Roxane van Heurck, Lars van der Veken, Laura Valle, Paolo Uva, Bjarne Udd, Aurelien Trimouille, Rachel Thompson, Marco Tartaglia, Yves Sznajer, Pasquale Striano, Verena Steinke-Lange, Martha Spilioti, Paolo Scudieri, Evelin Schröck, Katherine Schon, Marcello Scala, Helen Leavis, Manon Huibers, Marielle van Gijn, Geert de Vries, , Steven Laurie
npj Genomic Medicine, 2024, vol. 9

YajC, a predicted membrane protein, promotes Enterococcus faecium biofilm formation in vitro and in a rat endocarditis model Janetta Top, Xinglin Zhang, Antoni P.A. Hendrickx, Sjef Boeren, Willem van Schaik, Johannes Huebner, Rob J.L. Willems, Helen L. Leavis, Fernanda L. Paganelli
FEMS Microbes, 2024, vol. 5

Neurological phenotype of adenosine deaminase 2 deficient patients Merelijne A Verschoof, Laura C C van Meenen, M Valérie E Andriessen, Daniëlle M C Brinkman, Sylvia Kamphuis, Taco W Kuijpers, Helen L Leavis, G Elizabeth Legger, Catharina M Mulders-Manders, Anne P J de Pagter, Abraham Rutgers, Gijs T J van Well, Jonathan M Coutinho, A Elisabeth Hak, Joris M van Montfrans, Femke C C Klouwer
European Journal of Neurology, 2023, vol. 31, p.1-9

Fellowships & Awards

2019: Foundation for rare diseases grant – The role of intestinal bacteria in immunoglobulin A deficiency