Profile photo Helen Leavis

Helen Leavis

Full Professor

Strategic program(s):

Biography

Helen L. Leavis has been appointed Professor of Clinical Immunology as of May 1, 2025, and has been working as an internist-clinical immunologist at the Department of Rheumatology & Clinical Immunology at UMC Utrecht since 2013. Her clinical focus is on patients with complex immunological diseases, including primary immunodeficiencies and autoinflammatory disorders. As a clinical scientist, Helen is able to dedicate part of her time to initiating and conducting scientific research. As a (principal) investigator, her research centers on the development of healthcare innovations for these patients using AI tools, and on making new treatments available through precision medicine and drug repurposing.

Helen obtained her medical degree in 2003 from Utrecht University, where she also earned her PhD in 2007 with a thesis titled Evolutionary insights into CC17 Enterococcus faecium. From 2016 to 2022, Helen Leavis served as program manager of the subspecialty of Allergy & Clinical Immunology within Internal Medicine at the UMC Utrecht. Throughout her career, Helen Leavis has held various national and international academic roles, including reviewer and editor for medical journals, organizer of scientific conferences, and advisor to professional organizations and funding bodies. She is (co-)author of approximately 90 publications in international scientific journals.

Research groups

Rheumatology & clinical immunology

Research aim

To improve clinical practice by optimizing diagnosis, prognosis and treatment of rheumatic and immune-mediated and immune-deficient inflammatory diseases
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Primary immunodeficiency

Research aim

To address unmet medical needs by detecting novel primary immunodeficiency, and improving clinical practice by optimizing diagnosis, prognosis and treatment of disease.
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Translational microbiomics

Research aim

Our aim is to translate human microbiome knowledge to improved diagnostic tests and clinical interventions by incorporating systems biology into clinical epidemiological studies, conducting mechanistic laboratory studies, and linking the two.
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Recent publications

Proteins linked to type II interferon response in Sjögren’s disease Wing Yi Wong, Helen L. Leavis, Sofie L.M. Blokland, Valentin M.D. Baloche, Joel A.G. van Roon
Frontiers in Immunology, 2025, vol. 16
Correction to: Self-reported Clinical Outcomes and Quality of Life in Agammaglobulinemia: the Importance of an Early Diagnosis Maartje Blom, Annelotte J. Duintjer, Mahnaz Jamee, Melanie de Gier, Markéta Bloomfield, Adam Klocperk, Pavlina Kralickova, Neslihan E. Karaca, Oksana Boyarchuk, Peter Čižnár, Miloš Jeseňák, Svetlana Sharapova, Ekaterina Skopovets, Luis I. Gonzalez-Granado, Serena Palmeri, Stefano Volpi, Andrea Martin Nalda, Sonia Rodriguez Tello, Pere Soler-Palacín, Hassan Abolhassani, Federica Pulvirenti, Bianca Cinicola, Uwe Wintergerst, Godelieve J. de Bree, J. Merlijn van den Berg, Helen L. Leavis, Clementien Vermont, Virgil A.S.H. Dalm, Koen van Aerde, Stefanie Henriet, Hetty Jolink, Judith Potjewijd, Arjan Lankester, Chandoshi Rhea Mukherjee, Dagmar Berghuis, Małgorzata Pac, Benjamin M.J. Shillitoe, Andrew R. Gennery, Mirjam van der Burg
Journal of Clinical Immunology, 2025, vol. 45, p.1-2
Targeting B-cell activation to tackle both patient-reported and systemic disease outcomes in Sjögren's disease Dewi Rijnenberg, Safae Hamkour, Frank Redegeld, Helen Leavis, Joël van Roon
The Lancet. Rheumatology, 2025, vol. 7, p.e754-e756
Self-reported Clinical Outcomes and Quality of Life in Agammaglobulinemia Maartje Blom, Annelotte J Duintjer, Mahnaz Jamee, Melanie de Gier, Markéta Bloomfield, Adam Klocperk, Pavlina Kralickova, Neslihan E Karaca, Oksana Boyarchuk, Peter Čižnár, Miloš Jeseňák, Svetlana Sharapova, Ekaterina Skopovets, Luis I Gonzalez-Granado, Serena Palmeri, Stefano Volpi, Andrea Martin Nalda, Sonia Rodriguez Tello, Pere Soler Palacín, Hassan Abolhassani, Federica Pulvirenti, Bianca Cinicola, Uwe Wintergerst, Godelieve J de Bree, J Merlijn van den Berg, Helen L Leavis, Clementien Vermont, Virgil A S H Dalm, Koen van Aerde, Stefanie Henriet, Hetty Jolink, Judith Potjewijd, Arjan Lankester, Chandoshi Rhea Mukherjee, Dagmar Berghuis, Małgorzata Pac, Benjamin M J Shillitoe, Andrew R Gennery, Mirjam van der Burg
Journal of Clinical Immunology, 2025, vol. 45
Nasopharyngeal microbiome composition by SARS-CoV-2 presence and severity Juana Claus, Janetta Top, Fernanda L Paganelli, Thijs Ten Doesschate, Nienke Paternotte, Myka J Youngapelian, Rob Schuurman, Rob J L Willems, Helen Leavis, Janneke H H M van de Wijgert
Scientific Reports, 2025, vol. 15
Tocilizumab, sarilumab and anakinra in critically ill patients with COVID-19 Lennie Derde, Anthony C Gordon, Paul R Mouncey, Farah Al-Beidh, Kathryn M Rowan, Alistair D Nichol, Yaseen M Arabi, Djillali Annane, Abigail Beane, Richard Beasley, Marc J M Bonten, Charlotte A Bradbury, Frank M Brunkhorst, Adrian Buzgau, Meredith Buxton, Allen C Cheng, Nicola Cooper, Matthew Cove, Olaf L Cremer, Michelle A Detry, Eamon J Duffy, Lise J Estcourt, Mark Fitzgerald, James Galea, Rashan Haniffa, Thomas E Hills, David T Huang, Nao Ichihara, Andrew King, François Lamontagne, Patrick R Lawler, Helen L Leavis, Roger J Lewis, Edward Litton, John C Marshall, Florian B Mayr, Daniel F McAuley, Anna McGlothlin, Shay P McGuinness, Bryan J McVerry, Susan C Morpeth, Srinivas Murthy, Mihai G Netea, Kayode Ogungbenro, Katrina Orr, Rachael L Parke, Jane C Parker, Asad E Patanwala, Ville Pettila, Luis Felipe Reyes, Hiroki Saito, Marlene S Santos, Christina T Saunders, Christopher W Seymour, Manu Shankar-Hari, Wendy I Sligl, Alexis F Turgeon, Anne M Turner, Steven Y C Tong, Suvi Vaara, Taryn Youngstein, Ryan Zarychanski, Cameron Green, Alisa M Higgins, Colin J McArthur, Lindsay R Berry, Elizabeth Lorenzi, Scott Berry, Steve A Webb, Derek C Angus, Frank L van de Veerdonk
Thorax, 2025, vol. 80, p.530-539