Jurgen Kuball

Full Professor

Strategic program(s):

Biography

Prof. Dr. Jürgen Kuball is Chair of the Department of Hematology, and Director of the Bone Marrow Transplantation Program at the UMC Utrecht Cancer Centre. His research activities focus on tumor immunology and the ATMP development of a next generation of engineered immune cells, with an emphasis on the therapeutic potential of individual receptors derived from γδT cells. His clinical activities focus around acute leukemia and allogeneic stem cell transplantation. He is an active member of European Society for Blood and Marrow Transplantation (EBMT), and has chaired the Legal Regulatory Affairs Committee of the EBMT since 2019.

Dr. Kuball received his medical degree in Hematology at the University of Mainz, Germany, and completed his post-doctoral fellowship at the Fred Hutchinson Cancer Center in Seattle, WA, USA. He joined the Department of Hematology at the UMC Utrecht in 2007 as a hematologist and immunologist. In 2010, he became a VIDI-laureate, and the chair of the Applied & Tumor-Immunology section within the Laboratory of Translation Immunology. He has chaired the Department of Hematology (adults) since 2013.

For more information on experimental and translational research please visit Kuball Laboratories

Strategic program(s):

Contact

jkuball@umcutrecht.nl

Pure profile

Research groups

Tumor Immunology

Research aim

Our research aims to revolutionise cancer treatment by advancing innovative immunotherapies, ensuring safer, more effective therapies, and improving patient outcomes, ultimately transforming lives through cutting-edge translational cancer research.

Go to group

Recent publications

All publications

Design specifications for biomedical virtual twins in engineered adoptive cellular immunotherapies Ulrike Weirauch, Markus Kreuz, Colin Birkenbihl, Miriam Alb, Maria Quaranta, Laurence Calzone, Sophia Orozco-Ruiz, Stefanie Binder, Luise Fischer, Solène Clavreul, Morine Maguri, Maximilian Ferle, Michael Rade, Guillaume Azarias, Jay R Hydren, Jakub Jamarik, Daniel Schwarz, Zsolt Sebestyen, Jurgen Kuball, Georg Popp, Chloé Antoine, Manon Knockaert, Clara T Schoeder, David Fandrei, Carmen Sanges, Vaclovas Radvilas, Nico Gagelmann, Markus Rückert, Olaf Penack, Stephan Fricke, Andreas Schmidt, Carol Ward, Carl Steinbeisser, Jean-Marc Van Gyseghem, Anna Niarakis, Laurent Garderet, Michael Hudecek, Thomas Neumuth, Uwe Platzbecker, Ulrike Köhl, Regina Demlova, Andreas Kremer, Stefan Franke, Holger Fröhlich, Maximilian Merz, Kristin Reiche,
NPJ DIGITAL MEDICINE, 2025, vol. 8

Daratumumab for PRCA after HCT Nico Gagelmann, Moniek de Witte, Christophe Peczynski, William Boreland, Annoek E C Broers, Edgar Jost, Alexander Kulagin, Albert Esquirol, Simona Sica, Jürgen Kuball, Gerardo Errico, Wolfgang Bethge, Johan Maertens, Friedrich Stölzel, Edouard Forcade, Matthew Collin, Matteo Parma, Goda Choi, Nicolaus Kröger, Maria Chiara Di Chio, Maria Chiara Finazzi, Lucia López Corral, Jose Rifón, Alberto Mussetti, Adrian Bloor, Marco Ladetto, Hélène Schoemans, Olaf Penack, Ivan Moiseev, Zinaida Peric
Blood cancer journal, 2025, vol. 15, p.1-8

Disrupting the balance between activating and inhibitory receptors of γδT cells for effective cancer immunotherapy Dennis X Beringer, Trudy Straetemans, Susana Minguet, Caterina Riillo, Lydia Lynch, Zsolt Sebestyen, Jürgen Kuball
Nature Reviews Cancer, 2025, vol. 25, p.590-612

A Revised Prognostic Model for Patients with Acute Myeloid Leukemia and First Relapse Niek G Van Der Maas, Dimitri A Breems, Clara P W Klerk, Thomas Pabst, Patrycja Gradowska, Abin Thomas, Bart J Biemond, Jürgen Kuball, Catharina H M J van Elssen, Otto J Visser, Marie-Christiane Madeleine Vekemans, Carlos Graux, Johan A Maertens, Steven Knapper, Mike Dennis, Sylvie D Freeman, Ian Thomas, Berna H Beverloo, Gerwin A Huls, Charles Craddock, Peter J M Valk, Paresh Vyas, Nigel H Russell, Gert J Ossenkoppele, Bob Löwenberg, Jan J Cornelissen, Jurjen Versluis
Blood Advances, 2025, vol. 9, p.3853-3864

Engineering anti-BCMA CAR T cells for enhancing myeloma killing efficacy via apoptosis regulation Thomas Kimman, Marta Cuenca, Ralph G Tieland, Dedeke Rockx-Brouwer, Jasmijn Janssen, Benjamin Motais, Anne Slomp, Corine Pleijte, Sabine Heijhuurs, Angelo D Meringa, Wendy Boschloo, Douwe Mt Bosma, Sanne Kroos, Vania Lo Presti, Joost P G Sluijter, Stefan Nierkens, Niels Bovenschen, Jürgen Kuball, Alain van Mil, Monique C Minnema, Zsolt Sebestyén, Victor Peperzak
Nature Communications, 2025, vol. 16

Urgent need Simona Pagliuca, Christoph Schmid, Nicole Santoro, Federico Simonetta, Giorgia Battipaglia, Thierry Guillaume, Raffaella Greco, Francesco Onida, Isabel Sánchez-Ortega, Ibrahim Yakoub-Agha, Florent Malard, Jurgen Kuball, Mette D Hazenberg, Annalisa Ruggeri
Lancet haematology, 2025, vol. 12, p.e327-e328

Fellowships & Awards

American Association of Cancer Research-GlaxoSmithKline Scholar in Cancer Research Award (2001)
Stipendiat der Deutschen Krebshilfe (2005-2007)
Team Science recognition award of the „Society for Immunotherapy of Cancer“ to Jürgen Kuball and the University of Washington, USA (2010)
VIDI-Laureate ZonMW, The Netherlands (2010)

External positions

aandeelhouder - shareholder via Gadeta Founders - Century Therapeutics & Adeta

Chair - Chairing - Immunology Community Life Science

Secretary team member - bestuurslid - GoCART Coalition (EBMT/EHA)

Inkomsten licentie - Onderzoek - UMCU Holding

Commissie lid PPS commissie - grant indieningen voor KWF beoordelen - KWF

aandeelhouder - Receiving revenues from licensed patents via UMCU - UMC Holding

Chair legal and rgulatory affairs committee - Chair - EBMT

grant - grant ontvangen voor onderzoek - Novartis

Onderzoeker - grant ontvangen voor onderzoek - Miltenyi

bestuurslid - member general Board - HOVON

Patent holder multipe inventions licensed to Gadeta-follow up company Century Therapeuitcs &Miltenyi - Patent houder - Various