Profile photo Onno Kranenburg

Onno Kranenburg

Full Professor

Biography

Onno Kranenburg received his PhD in 1995 from Leiden University (Prof Lex van der Eb). He then studied RAS and RHO small GTPase signaling in cancer in the Netherlands Cancer Institute (Prof Wouter Moolenaar). In 2000 he became senior Post-Doc in the Dept of Medical Oncology in the UMC Utrecht (Prof Emile Voest) where he started his translational studies on the mechanism of action of anti-angiogenic drugs. In 2003 he became Assistant Professor and PI at the Dept. of Surgery (Prof Inne Borel Rinkes) and started to work on the mechanisms of colon cancer metastasis, initially focusing on the role of the K-RAS oncogene.  In 2006 he became Associate Professor, head of the Surgery Lab and staff member at the Dept. of Surgery. In 2012 he became coordinator of the PhD research school Clinical and Translational Oncology. In 2015 he was appointed Professor of Surgical and Translational Tumor Biology at the Cancer Center UMC Utrecht where he continues to design and test novel strategies for the prevention and treatment of colon cancer metastasis. 

Research groups

Translational oncology

Research aim

To develop, test, and implement novel therapeutic and diagnostic strategies to combat cancer by integrating fundamental and clinical research.

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Recent publications

Peritoneal resident macrophages constitute an immunosuppressive environment in peritoneal metastasized colorectal cancer J Saris, A Y F Li Yim, S Bootsma, K J Lenos, R Franco Fernandez, H N Khan, J Verhoeff, D Poel, N M Mrzlikar, L Xiong, M P Schijven, N C T van Grieken, O Kranenburg, M E Wildenberg, A Logiantara, C Jongerius, J J Garcia Vallejo, S S Gisbertz, S Derks, J B Tuynman, G R A M D'Haens, L Vermeulen, J Grootjans
Nature Communications, 2025, vol. 16
Quantifying cell divisions along evolutionary lineages in cancer Martin Blohmer, David M. Cheek, Wei Ting Hung, Maria Kessler, Foivos Chatzidimitriou, Jiahe Wang, William Hung, I. Hsiu Lee, Alexander N. Gorelick, Emma C.E. Wassenaar, Ching Yeuh Yang, Yi Chen Yeh, Hsiang Ling Ho, Dorothee Speiser, Maria M. Karsten, Michael Lanuti, Sara I. Pai, Onno Kranenburg, Jochen K. Lennerz, Teh Ying Chou, Matthias Kloor, Kamila Naxerova
Nature genetics, 2025, vol. 57, p.706–717
A unique interplay of access and selection shapes peritoneal metastasis evolution in colorectal cancer Emma Ce Wassenaar, Alexander N Gorelick, Wei-Ting Hung, David M Cheek, Emre Kucukkose, I-Hsiu Lee, Martin Blohmer, Sebastian Degner, Peter Giunta, Rene Mj Wiezer, Mihaela G Raicu, Inge Ubink, Sjoerd J Klaasen, Nico Lansu, Emma V Watson, Ryan B Corcoran, Genevieve Boland, Gad Getz, Geert Jpl Kops, Dejan Juric, Jochen K Lennerz, Djamila Boerma, Onno Kranenburg, Kamila Naxerova
2024
Radiation Lobectomy in Adjunct to Double Vein Embolization to Reach Sufficient Future Liver Remnant in Patients with Colorectal Cancer Liver Metastases D. Andel, K. Ramdhani, A.J.A.T. Braat, R.C.G. Bruijnen, G. Bol, G. Keane, M.G.E.H. Lam, O.W. Kranenburg, I.H.M.Borel Rinkes, J. Hagendoorn, M.L.J. Smits
Cardiovascular and Interventional Radiology, 2024, vol. 48, p.379-385
VEGF-C propagates ‘onward’ colorectal cancer metastasis from liver to lung Susanna Poghosyan, Nicola Frenkel, Lotte van den Bent, Danielle Raats, Tessa Spaapen, Jamila Laoukili, Inne Borel Rinkes, Onno Kranenburg, Jeroen Hagendoorn
British Journal of Cancer, 2024, vol. 132, p.69-80
Reclassification of Appendiceal Mucinous Neoplasms and Associated Pseudomyxoma Peritonei According to the Peritoneal Surface Oncology Group International Consensus Paulien Rauwerdink, Dania Al-Toma, Emma C.E. Wassenaar, Mihaela G. Raicu, Miangela M. Laclé, Anya N. Milne, Karel C. Kuijpers, Clément J.R. Huysentruyt, Floris B. Poelmann, Bert van Ramshorst, Sjoerd G. Elias, Onno Kranenburg, Inne H.M. Borel Rinkes, Arjen J. Witkamp, Marinus J. Wiezer, Helma M.U. van Grevenstein, Djamila Boerma
Annals of surgical oncology, 2024, vol. 31, p.8572-8584

Fellowships & Awards

1. KWF2015-8088. Targeting mesenchymal-tyope colon cancer by aggravating oxidative damage. €573.500. 
2. Scope: Modulation of chemotherapy efficacy and toxicity by nutrition in metastatic colorectal cancer. €586.000.
3. ZonMw 2014: PDGF-receptor-targeted therapy for the treatment of poor prognosis mesenchymal-type colon cancer: A window trial. €108.000
4. Gieskes-Strijbis Fonds 2014: The relationship between primary colorectal tumors and their liver metastases: Biological subgroups and therapy response. €290.000
5. Vrienden UMC Utrecht 2013. Title: Targeting colon tumors at their root: Elimination of Cancer Stem Cells. €217.000   
6. KWF UU2011-5226 Title: LIMK1 control of CD95 function in colorectal cancer. €553.300   
7. KWF UU2011-5135. Suppression of LIMK1 by oncogenic KRAS and RAF1: A critical survival pathway in colorectal cancer? €560.000
8. KWF UU2009-4417. The contribution of CD95 signalling to recurrence of colorectal liver metastases following radiofrequency ablation. €592.100   

External positions

Chair - supervision UPORT facility team - Utrecht Platform for Organoid technology