Profile photo Onno Kranenburg

Onno Kranenburg

Full Professor

Biography

Onno Kranenburg received his PhD in 1995 from Leiden University (Prof Lex van der Eb). He then studied RAS and RHO small GTPase signaling in cancer in the Netherlands Cancer Institute (Prof Wouter Moolenaar). In 2000 he became senior Post-Doc in the Dept of Medical Oncology in the UMC Utrecht (Prof Emile Voest) where he started his translational studies on the mechanism of action of anti-angiogenic drugs. In 2003 he became Assistant Professor and PI at the Dept. of Surgery (Prof Inne Borel Rinkes) and started to work on the mechanisms of colon cancer metastasis, initially focusing on the role of the K-RAS oncogene.  In 2006 he became Associate Professor, head of the Surgery Lab and staff member at the Dept. of Surgery. In 2012 he became coordinator of the PhD research school Clinical and Translational Oncology. In 2015 he was appointed Professor of Surgical and Translational Tumor Biology at the Cancer Center UMC Utrecht where he continues to design and test novel strategies for the prevention and treatment of colon cancer metastasis. 

Research groups

Translational oncology

Research aim

To develop, test, and implement novel therapeutic and diagnostic strategies to combat cancer by integrating fundamental and clinical research.

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Recent publications

90Y-/166Ho- ‘Radiation lobectomy’ for liver tumors induces abnormal morphology and impaired drainage of peritumor lymphatics Daan Andel, Lotte van den Bent, Marnix Lam, Maarten Smits, Isaac Quintus Molenaar, Joep de Bruijne, Miangela Marie Laclé, Onno Kranenburg, Inne Borel Rinkes, Jeroen Hagendoorn
JHEP Reports, 2024, vol. 6, p.1-9
Onward Spread from Liver Metastases Is a Major Cause of Multi-Organ Metastasis in a Mouse Model of Metastatic Colon Cancer Liza A Wijler, Bastiaan J Viergever, Esther Strating, Susanne J van Schelven, Susanna Poghosyan, Nicola C Frenkel, Hedy Te Rietmole, Andre Verheem, Danielle A E Raats, Inne H M Borel Rinkes, Jeroen Hagendoorn, Onno Kranenburg
Cancers, 2024, vol. 16
Exploiting a subtype-specific mitochondrial vulnerability for successful treatment of colorectal peritoneal metastases Sanne Bootsma, Mark P.G. Dings, Job Kesselaar, Roxan F.C.P.A. Helderman, Kyah van Megesen, Alexander Constantinides, Leandro Ferreira Moreno, Ellen Stelloo, Enzo M. Scutigliani, Bella Bokan, Arezo Torang, Sander R. van Hooff, Danny A. Zwijnenburg, Valérie M. Wouters, Vincent C.J. van de Vlasakker, Laskarina J.K. Galanos, Lisanne E. Nijman, Adrian Logiantara, Veronique L. Veenstra, Sophie Schlingemann, Sterre van Piggelen, Nicole van der Wel, Przemek M. Krawczyk, Johannes J. Platteeuw, Jurriaan B. Tuynman, Ignace H. de Hingh, Jan P.G. Klomp, Arthur Oubrie, Petur Snaebjornsson, Jan Paul Medema, Arlene L. Oei, Onno Kranenburg, Clara C. Elbers, Kristiaan J. Lenos, Louis Vermeulen, Maarten F. Bijlsma
Cell Reports Medicine, 2024, vol. 5
Pre-existing subclones determine radioresistance in rectal cancer organoids Daan Andel, Bas Viergever, Niek Peters, Danielle Raats, Susanne Schenning-van Schelven, Martijn Intven, Maurice Zandvliet, Jeroen Hagendoorn, Inne Borel Rinkes, Onno Kranenburg
Cell Reports, 2024, vol. 43
Differential cytokine and chemokine expression after ablation vs. resection in colorectal cancer liver metastasis Nicola Frenkel, Susanna Poghosyan, Jan Willem van Wijnbergen, Inne Borel Rinkes, Onno Kranenburg, Jeroen Hagendoorn
Surgery Open Science, 2024, vol. 18, p.29-34
Radiation response assessment of organoids derived from patients with pancreatic cancer Iris W.J.M. van Goor, Leon Raymakers, Daan S.H. Andel, Lodewijk A.A. Brosens, Onno Kranenburg, Jeanette H.W. Leusen, Gert J. Meijer, I. Quintus Molenaar, Hjalmar C. van Santvoort, J. H.Wilfred de Vries, Andre J.M. Wopereis, Martijn P.W. Intven, Lois A. Daamen
Clinical and translational radiation oncology, 2024, vol. 48

External positions

Chair - supervision UPORT facility team - Utrecht Platform for Organoid technology