Profile photo Kors van der Ent

Kors van der Ent

Full Professor

Strategic program(s):

Biography

The research interests of professor Kors van der Ent focus on the themes Cystic Fibrosis and other bronchusobstructive diseseases in young children. He is the leader of the national HIT-CF program which focuses on the development and personalised application of new drugs influencing the basis genetic defect in patients with CF. This program includes both mechanistic studies in collaboration with the Hubrecht lab and the Byvoet Center as well as studies into host pathogen interaction in collaboration with the veterinary faculty of the Utrecht University. Clinical studies are performed in close collaboration with other CF-centres throughout Europe. Furthermore, he was the founder of the Whistler birth cohort, in which thousands of children are followed from birth to study determinants of the development of respiratory diseases. These cohorts mirror normal development to understand mechanisms in disease.

Kors van der Ent has special interest in innovation and valorisation in medical care and believes in creation of hospital networks to build the future medical care system for children. He successfully developed new devices to measure neonatal lung function, which were launched to the market. He also developed the Luchtwegportaal, an interactive web-based system to collect patient data regarding respiratory diseases in many hospitals in The Netherlands.

Research groups

Cellular disease models

Research aim

To develop patient-derived cell models to understand the molecular mechanisms of disease, to identify and validate targets for treatment, and to develop drugs and precision medicine applications.
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Pediatric pulmonology

Research aim

We unravel biological, clinical and psychosocial aspects of lung diseases like Cystic Fibrosis, Primary Ciliary Dyskinesia and oncology to continuously improve diagnosis and treatment by implementing latest scientific insights into clinical care.
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Recent publications

OrgaSegment Juliet W Lefferts, Suzanne Kroes, Matthew B Smith, Paul J Niemöller, Natascha D A Nieuwenhuijze, Heleen N Sonneveld van Kooten, Cornelis K van der Ent, Jeffrey M Beekman, Sam F B van Beuningen
Communications biology, 2024, vol. 7
Enhanced aortic stiffness in adolescents with chronic disease is associated with decreased left ventricular global longitudinal strain Victor A Verpalen, Francesca A Ververs, Martijn Slieker, Roos Nuboer, Joost F Swart, Cornelis K van der Ent, Zina Fejzic, Jos J M Westenberg, Tim Leiner, Heynric B Grotenhuis, Henk S Schipper
IJC Heart and Vasculature, 2024, vol. 52
BMI increase during early childhood in boys with cystic fibrosis and early adrenarche Gizem Tamer, Hubertus Gerardus Maria Arets, Cornelis Kors van der Ent, Hanneke Margo van Santen, Hetty Jacoba van der Kamp
Pediatric Pulmonology, 2024, vol. 59, p.991-996
A dyadic perspective on parent-child dyadic coping in children with a chronic condition Reine C. van der Wal, Sanne L. Nijhof, Luca M. Leisten, Elise M. van de Putte, Cornelis K. van der Ent, Alinde W. Hindriks-Keegstra, Guy Bodenmann, Catrin Finkenauer, Merel M. Nap-van der Vlist
Journal of Psychosomatic Research, 2024, vol. 181
Radiological and long-term clinical response to elexacaftor/tezacaftor/ivacaftor in people with cystic fibrosis with advanced lung disease Bente L. Aalbers, Firdaus A.A. Mohamed Hoesein, Regina W. Hofland, Inez Bronsveld, Marian A. Kruijswijk, Suzan Schotman, Corlien W. Slingerland, Hannah Panhuis, C. Kors van der Ent, Harry G.M. Heijerman
Pediatric Pulmonology, 2023, vol. 58, p.2317-2322
Is Measuring Physical Literacy in School-Aged Children With Cystic Fibrosis or Congenital Heart Disease Needed? Johannes J. Noordstar, Maaike C.A. Sprong, Martijn G. Slieker, Tim Takken, Marco van Brussel, Cornelis K. van der Ent, Erik H.J. Hulzebos
Pediatric Physical Therapy, 2023, vol. 35, p.43-47