Kevin Kenna

Associate Professor

Strategic program(s):

Contact

kkenna@umcutrecht.nl

Pure profile

Research groups

Neurogenetics

Research aim

Given increasing possibilities in gene-based therapies for ALS, the overall aim of my research is to elucidate the exact genetic contribution in every patient to liability to disease.

Go to group

Recent publications

All publications

Rare and common genetic determinants of mitochondrial function determine severity but not risk of amyotrophic lateral sclerosis Calum Harvey, Marcel Weinreich, James A.K. Lee, Allan C. Shaw, Laura Ferraiuolo, Heather Mortiboys, Sai Zhang, Paul J. Hop, Ramona A.J. Zwamborn, Kristel van Eijk, Thomas H. Julian, Tobias Moll, Alfredo Iacoangeli, Ahmad Al Khleifat, John P. Quinn, Abigail L. Pfaff, Sulev Kõks, Joanna Poulton, Stephanie L. Battle, Dan E. Arking, Michael P. Snyder, Jan H. Veldink, Kevin P. Kenna, Pamela J. Shaw, Johnathan Cooper-Knock,
Heliyon, 2024, vol. 10

Considerations in the search for epistasis Marleen Balvert, Johnathan Cooper-Knock, Julian Stamp, Ross P. Byrne, Soufiane Mourragui, Juami van Gils, Stefania Benonisdottir, Johannes Schlüter, Kevin Kenna, Sanne Abeln, Alfredo Iacoangeli, Joséphine T. Daub, Brian L. Browning, Gizem Taş, Jiajing Hu, Yan Wang, Elham Alhathli, Calum Harvey, Luna Pianesi, Sara C. Schulte, Jorge González-Domínguez, Erik Garrisson, Bogdan Pasanuic, Sai Zhang, Sebastian Vorbrugg, Jasper van Bemmelen, Raghuram Dandinasivara, Magda Markowska, Mehmet Koyuturk, Andrea Guarracino, Paola Bonizzoni, Davide Bolognini, Joanna von Berg, Jasmijn Baaijens, Jorge Avila Cartes, Ammar Al-Chalabi, Michael P. Snyder, Alexander Schönhuth, Letitia M.F. Sng, Natalie A. Twine,
Genome Biology, 2024, vol. 25

Mechanism-free repurposing of drugs for C9orf72-related ALS/FTD using large-scale genomic data Sara Saez-Atienzar, Cleide dos Santos Souza, Ruth Chia, Selina N. Beal, Ileana Lorenzini, Ruili Huang, Jennifer Levy, Camelia Burciu, Jinhui Ding, J. Raphael Gibbs, Ashley Jones, Ramita Dewan, Viviana Pensato, Silvia Peverelli, Lucia Corrado, Joke J.F.A. van Vugt, Wouter van Rheenen, Ceren Tunca, Elif Bayraktar, Menghang Xia, Robert H. Baloh, Robert Bowser, Christopher B. Brady, Alexis Brice, James Broach, William Camu, Adriano Chio, John Cooper-Knock, Daniele Cusi, Carsten Drepper, Vivian E. Drory, Travis L. Dunckley, Eva Feldman, Mary Kay Floeter, Pietro Fratta, Glenn Gerhard, Summer B. Gibson, Jonathan D. Glass, Stephen A. Goutman, John Hardy, Matthew B. Harms, Terry D. Heiman-Patterson, Lilja Jansson, Janine Kirby, Hannu Laaksovirta, John E. Landers, Russell McLaughlin, Kevin Kenna, Leonard H. van den Berg, Jan H. Veldink, , , ,
Cell genomics, 2024, vol. 4

Systematic rare variant analyses identify RAB32 as a susceptibility gene for familial Parkinson’s disease Paul J. Hop, Dongbing Lai, Pamela J. Keagle, Desiree M. Baron, Brendan J. Kenna, Maarten Kooyman, Shankaracharya, Cheryl Halter, Letizia Straniero, Rosanna Asselta, Salvatore Bonvegna, Alexandra I. Soto-Beasley, , Zbigniew K. Wszolek, Ryan J. Uitti, Ioannis Ugo Isaias, Gianni Pezzoli, Nicola Ticozzi, Owen A. Ross, Jan H. Veldink, Tatiana M. Foroud, Kevin P. Kenna, John E. Landers
Nature Genetics, 2024, vol. 56, p.1371-1376

Genetic variability in sporadic amyotrophic lateral sclerosis Sien Hilde Van Daele, Matthieu Moisse, Joke J F A van Vugt, Ramona A J Zwamborn, Rick van der Spek, Wouter van Rheenen, Kristel Van Eijk, Kevin Kenna, Philippe Corcia, Patrick Vourc'h, Philippe Couratier, Orla Hardiman, Russell McLaughin, Marc Gotkine, Vivian Drory, Nicola Ticozzi, Vincenzo Silani, Antonia Ratti, Mamede de Carvalho, Jesús S Mora Pardina, Monica Povedano, Peter M Andersen, Markus Weber, Nazli A Başak, Chris Shaw, Pamela J Shaw, Karen E Morrison, John E Landers, Jonathan D Glass, Michael van Es, Leonard H van den Berg, Ammar Al-Chalabi, Jan Veldink, Philip Van Damme
Brain : a journal of neurology, 2023, vol. 146, p.3760-3769

Genome-wide study of DNA methylation shows alterations in metabolic, inflammatory, and cholesterol pathways in ALS Paul J Hop, Ramona A J Zwamborn, Eilis Hannon, Gemma L Shireby, Marta F Nabais, Emma M Walker, Wouter van Rheenen, Joke J F A van Vugt, Annelot M Dekker, Henk-Jan Westeneng, Gijs H P Tazelaar, Kristel R van Eijk, Matthieu Moisse, Denis Baird, Ahmad Al Khleifat, Alfredo Iacoangeli, Nicola Ticozzi, Antonia Ratti, Jonathan Cooper-Knock, Karen E Morrison, Pamela J Shaw, A Nazli Basak, Adriano Chiò, Andrea Calvo, Cristina Moglia, Antonio Canosa, Maura Brunetti, Maurizio Grassano, Marc Gotkine, Yossef Lerner, Michal Zabari, Patrick Vourc'h, Philippe Corcia, Philippe Couratier, Jesus S Mora Pardina, Teresa Salas, Patrick Dion, Jay P Ross, Robert D Henderson, Michael A van Es, R Jeroen Pasterkamp, Russell L McLaughlin, Kevin P Kenna, Leonard H van den Berg, Jan H Veldink, Jan H Veldink, Leonard H van den Berg, Patrick Deelen, Patrick Deelen, Jan H Veldink,
Science translational medicine, 2022, vol. 14, p.1-15