Kevin Kenna

Associate Professor

Strategic program(s):

Contact

k.p.kenna@umcutrecht.nl

Pure profile

Research groups

Neurogenetics

Research aim

Given increasing possibilities in gene-based therapies for ALS, the overall aim of my research is to elucidate the exact genetic contribution in every patient to liability to disease.

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Recent publications

All publications

Antisense oligonucleotide depletion of CCDC146 is a broad-spectrum therapeutic strategy for ALS Sai Zhang, Tobias Moll, Jasper Rubin-Sigler, Sharon Tu, Shuya Li, Enming Yuan, Menghui Liu, Marriane King, Elham Alhathli, Connie Treanor, Alison Twelvetrees, Marcel Weinreich, Sam Bonsall, Calum Harvey, Sarah Gornall, Allan Shaw, Johanna Ganssauge, Akshay Bhinge, Cleide Dos Santos Souza, Laura Ferraiuolo, Eran Hornstein, Ophir Shalem, Anna Avila, Tatyana Shelkovnikova, Charlotte H van Dijk, Ilia S Timpanaro, Kevin P Kenna, Jianyang Zeng, Philip van Damme, Philip S Tsao, Pamela J Shaw, Justin K Ichida, Johnathan Cooper-Knock, Michael P Snyder
2025

Optimised machine learning for time-to-event prediction in healthcare applied to timing of gastrostomy in ALS Marcel Weinreich, Harry McDonough, Mark Heverin, Éanna Mac Domhnaill, Nancy Yacovzada, Iddo Magen, Yahel Cohen, Calum Harvey, Ahmed Elazzab, Sarah Gornall, Sarah Boddy, James J.P. Alix, Julian M. Kurz, Kevin P. Kenna, Sai Zhang, Alfredo Iacoangeli, Ahmad Al-Khleifat, Michael P. Snyder, Esther Hobson, Adriano Chio, Andrea Malaspina, Andreas Hermann, Caroline Ingre, Juan Vazquez Costa, Leonard van den Berg, Monica Povedano Panadés, Philip van Damme, Phillipe Corcia, Mamede de Carvalho, Ammar Al-Chalabi, Eran Hornstein, Eran Elhaik, Pamela J. Shaw, Orla Hardiman, Christopher McDermott, Johnathan Cooper-Knock
EBioMedicine, 2025, vol. 121

SpliPath enhances disease gene discovery in case-control analyses of rare splice-altering genetic variants Yan Wang, Charlotte van Dijk, Ilia Timpanaro, Paul Hop, Brendan Kenna, Maarten Kooyman, Eleonora Aronica, R. Jeroen Pasterkamp, Leonard H. van den Berg, Johnathan Cooper-Knock, Jan H. Veldink, Kevin Kenna, ,
Cell reports methods, 2025, vol. 5, p.1-12

Correction to Marleen Balvert, Johnathan Cooper-Knock, Julian Stamp, Ross P. Byrne, Soufane Mourragui, Juami van Gils, Stefania Benonisdottir, Johannes Schlüter, Kevin Kenna, Sanne Abeln, Alfredo Iacoangeli, Joséphine T. Daub, Brian L. Browning, Gizem Taş, Jiajing Hu, Yan Wang, Elham Alhathli, Calum Harvey, Luna Pianesi, Sara C. Schulte, Jorge González-Domínguez, Erik Garrisson, Michael P. Snyder, Alexander Schönhuth, Letitia M.F. Sng, Natalie A. Twine,
Genome Biology, 2025, vol. 26

Evaluation of a biomarker for amyotrophic lateral sclerosis derived from a hypomethylated DNA signature of human motor neurons Calum Harvey, Alicja Nowak, Sai Zhang, Tobias Moll, Annika K. Weimer, Aina Mogas Barcons, Cleide Dos Santos Souza, Laura Ferraiuolo, Kevin Kenna, Noah Zaitlen, Christa Caggiano, Pamela J. Shaw, Michael P. Snyder, Jonathan Mill, Eilis Hannon, Johnathan Cooper-Knock
BMC Medical Genomics, 2025, vol. 18

Considerations in the search for epistasis Marleen Balvert, Johnathan Cooper-Knock, Julian Stamp, Ross P. Byrne, Soufiane Mourragui, Juami van Gils, Stefania Benonisdottir, Johannes Schlüter, Kevin Kenna, Sanne Abeln, Alfredo Iacoangeli, Joséphine T. Daub, Brian L. Browning, Gizem Taş, Jiajing Hu, Yan Wang, Elham Alhathli, Calum Harvey, Luna Pianesi, Sara C. Schulte, Jorge González-Domínguez, Erik Garrisson, Bogdan Pasanuic, Sai Zhang, Sebastian Vorbrugg, Jasper van Bemmelen, Raghuram Dandinasivara, Magda Markowska, Mehmet Koyuturk, Andrea Guarracino, Paola Bonizzoni, Davide Bolognini, Joanna von Berg, Jasmijn Baaijens, Jorge Avila Cartes, Ammar Al-Chalabi, Michael P. Snyder, Alexander Schönhuth, Letitia M.F. Sng, Natalie A. Twine,
Genome Biology, 2024, vol. 25