Jos Malda

Full Professor

Strategic program(s):

Biography

Our research group focuses on biofabrication and biomaterials design, in particular for the regeneration of (osteo) chondral defects. We are developing novel biofabriaction strategies, as well and “bioinks” for 3D printing. These hydrogel-based “inks” are both designed to drive specific differentiation of the embedded and/or endogenous cells, as well as to allow fabrication with high shape fidelity in order to generate constructs that are a blueprint of the real tissue. In addition, we are adopting bioreactor technology to mature the generated tissue constructs. Finally, approaches towards the translation of the constructs in veterinary (equine) and human clinics are pursued, including its use as an in vitro platform for testing.

Areas of interest
- Joint regeneration
- Biofabrication

- Biomaterial development

- Bioreactors

- Extracellular matrix-derived scaffolds

- Nutrient limitation

Strategic program(s):

Contact

Pure profile

Research groups

Biofabrication in translational regenerative medicine

Research aim

We focus on biofabrication technologies & regenerative models to create lifelike tissue implants and advanced disease models. We aim to revolutionize treatment options for musculoskeletal injuries and better understanding of tissue health.

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Recent publications

All publications

A comparison between a patient-specific bone regenerative implant and the osteochondral allograft procedure in a Hill-Sachs lesion, a cadaveric study Michał S. Gałek-Aldridge, Koen Willemsen, Sophie H. Nelissen, Bart C.H. van der Wal, Jos Malda, Michel P.J. van den Bekerom, Arthur van Noort
JSES Reviews, Reports, and Techniques, 2025, vol. 6

Adaptive and context-aware volumetric printing Sammy Florczak, Gabriel Größbacher, Davide Ribezzi, Alessia Longoni, Marième Gueye, Estée Grandidier, Jos Malda, Riccardo Levato
Nature, 2025, vol. 645, p.108-114

Half-Pipe Melt Electrowritten Scaffolds Support Engineering of an Immunocompetent Hydrogel-Embedded Intestine-on-a-Chip Robine Janssen, Henrike S Schulze, Claire M L Nelissen, Marta G Valverde, Andrei Hrynevich, Govardus A H de Jong, Anne Metje van Genderen, Jos Malda, Shanna Bastiaan-Net, Linette E M Willemsen, Rosalinde Masereeuw
Advanced Science, 2025, vol. 12

Engineering Anisotropic Mechanical Properties in Large-Scale Fabricated Cartilage Constructs Using Microfiber Reinforcement Lennard Spauwen, Alba Pueyo Moliner, Patrick van Veenendaal, Roel Custers, Jos Malda, Mylène de Ruijter
Advanced Healthcare Materials, 2025, vol. 14

Non-destructive assessment of tissue engineered cartilage maturity using visible and near infrared spectroscopy combined with machine learning Omar Anwar Elkadi, Florencia Abinzano, Ervin Nippolainen, Ona Bach González, Juha Töyräs, Riccardo Levato, Jos Malda, Isaac O. Afara
Biosensors and Bioelectronics, 2025, vol. 286

Testing a new sustained-release local anesthetic formulation specifically designed for spine surgery in a sheep model Jasper G Steverink, Floris R van Tol, Suzanne Bruins, Kwame B Amponsah, Jessica Marvela, Andre J Smorenburg, Hein R Jonkman, Bas J Oosterman, Marijke R van Dijk, Jos Malda, Susanna Piluso, Jorrit-Jan Verlaan
International Journal of Pharmaceutics, 2025, vol. 678

Fellowships & Awards

Anna Prize 2017, Anna Foundation and Nederlandse Orthopaedische Vereniging

Nanonica Prize 2015 for the breakthrough of the year in the field of nanotechnology, Nanonica Europe

ERC Consolidator Grant ERC-2014-CoG_647426

NWO Veni Fellowship: Printen van levend kraakbeen