Joris Hageman

PHD Candidate - OIO

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jhagema2@umcutrecht.nl

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Recent publications

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Intestinal tuft cell subtypes represent successive stages of maturation driven by crypt-villus signaling gradients Julian R Buissant des Amorie, Max A Betjes, Jochem H Bernink, Joris H Hageman, Veerle E Geurts, Harry Begthel, Dimitrios Laskaris, Maria C Heinz, Ingrid Jordens, Tiba Vinck, Ronja M Houtekamer, Ingrid Verlaan-Klink, Sascha R Brunner, Jacco van Rheenen, Martijn Gloerich, Hans Clevers, Sander J Tans, Jeroen S van Zon, Hugo J G Snippert
Nature Communications, 2025, vol. 16

Homopolymer switches mediate adaptive mutability in mismatch repair-deficient colorectal cancer Hamzeh Kayhanian, William Cross, Suzanne E M van der Horst, Panagiotis Barmpoutis, Eszter Lakatos, Giulio Caravagna, Luis Zapata, Arne Van Hoeck, Sjors Middelkamp, Kevin Litchfield, Christopher Steele, William Waddingham, Dominic Patel, Salvatore Milite, Chen Jin, Ann-Marie Baker, Daniel C Alexander, Khurum Khan, Daniel Hochhauser, Marco Novelli, Benjamin Werner, Ruben van Boxtel, Joris H Hageman, Julian R Buissant des Amorie, Josep Linares, Marjolijn J L Ligtenberg, Iris D Nagtegaal, Miangela M Laclé, Leon M G Moons, Lodewijk A A Brosens, Nischalan Pillay, Andrea Sottoriva, Trevor A Graham, Manuel Rodriguez-Justo, Kai-Keen Shiu, Hugo J G Snippert, Marnix Jansen
Nature Genetics, 2024, vol. 56, p.1420-1433

Co-cultures of colon cancer cells and cancer-associated fibroblasts recapitulate the aggressive features of mesenchymal-like colon cancer Esther Strating, Mathijs P Verhagen, Emerens Wensink, Ester Dünnebach, Liza Wijler, Itziar Aranguren, Alberto Sanchez De la Cruz, Niek A Peters, Joris H Hageman, Mirjam M C van der Net, Susanne van Schelven, Jamila Laoukili, Riccardo Fodde, Jeanine Roodhart, Stefan Nierkens, Hugo Snippert, Martijn Gloerich, Inne Borel Rinkes, Sjoerd G Elias, Onno Kranenburg
Frontiers in Immunology, 2023, vol. 14

Efficient and error-free fluorescent gene tagging in human organoids without double-strand DNA cleavage Yannik Bollen, Joris H Hageman, Petra van Leenen, Lucca L M Derks, Bas Ponsioen, Julian R Buissant des Amorie, Ingrid Verlaan-Klink, Myrna van den Bos, Leon W M M Terstappen, Ruben van Boxtel, Hugo J G Snippert
PLoS Biology, 2022, vol. 20, p.1-16

Liver Colonization by Colorectal Cancer Metastases Requires YAP-Controlled Plasticity at the Micrometastatic Stage Maria C Heinz, Niek A Peters, Koen C Oost, Rik G H Lindeboom, Lisa van Voorthuijsen, Arianna Fumagalli, Mirjam C van der Net, Gustavo de Medeiros, Joris H Hageman, Ingrid Verlaan-Klink, Inne H M Borel Rinkes, Prisca Liberali, Martijn Gloerich, Jacco van Rheenen, Michiel Vermeulen, Onno Kranenburg, Hugo J G Snippert
Cancer Research, 2022, vol. 82, p.1953-1968

Chromosomal copy number heterogeneity predicts survival rates across cancers Erik van Dijk, Tom van den Bosch, Kristiaan J Lenos, Khalid El Makrini, Lisanne E Nijman, Hendrik F B van Essen, Nico Lansu, Michiel Boekhout, Joris H Hageman, Rebecca C Fitzgerald, Cornelis J A Punt, Jurriaan B Tuynman, Hugo J G Snippert, Geert J P L Kops, Jan Paul Medema, Bauke Ylstra, Louis Vermeulen, Daniël M Miedema
Nature Communications, 2021, vol. 12, p.1-12