Profile photo Jim van Os

Jim van Os

Full Professor

Strategic program(s):

Biography

I have a background in Epidemiology (London School of Hygiene and Tropical Medicine) and Psychiatry (Institute of Psychiatry, King’s College London). My research has focused on elucidating the nature of mental variation in relation to context, and identifying the interactions between environment and genetic liability driving this variation. Over the course of my career, I have developed a passion for making psychiatry more relevant for its users in terms of diagnostic practice, the use of scientific findings to create clinical impact, health service organization, teaching and co-creation with users. I think there is an urgent need to balance the discourse and the scientific focus of the psychiatric profession on the one hand, and the needs and wishes of patients and their relatives on the other. In my work as Neuroscience Division leader at MUMC and now UMCU, I have attempted to forge collaboration between the clinical neurosciences in order to create patient value, for example in the area of neuromodulation. After several decades of directing activities in health care and research, I think effective leadership is about facilitating others, creating a community and fostering the network – in the shared belief that our work serves to inspire students and impact the lives of patients.

Education

Basic Teaching Qualification, BROK certified

Ten most important scientific publications

  • Van Os, J., Hanssen, M., Bijl, R.V. & Vollebergh, W. (2001) Prevalence of psychotic disorder and community level of psychotic symptoms: an urban-rural comparison. Archives of General Psychiatry, 58, 663-668.

  • Van Os, J., Hanssen, M., Bak, M., et al (2003) Do urbanicity and familial liability coparticipate in causing psychosis? American Journal of Psychiatry, 160, 477-482.
  • Van Os, J., Altamura, A.C., Bobes, J. et al (2004) Evaluation of the Two-Way Communication Checklist as a clinical intervention. Results of a multinational, randomised controlled trial. British Journal of Psychiatry, 184, 79-83.
  • van Os, J. & Kapur, S. (2009) Schizophrenia. Lancet, 374, 635-645.
  • van Os, J., Kenis, G. & Rutten, B.P. (2010) The environment and schizophrenia. Nature, 468, 203-212.
  • van Os, J. & Reininghaus, U. (2016) Psychosis as a transdiagnostic and extended phenotype in the general population. World Psychiatry, 15, 118-124.
  • Van Os J, Marsman A, Van Dam D, Simons CJ, GROUP Investigators (2017). Evidence That the Impact of Childhood Trauma on IQ Is Substantial in Controls, Moderate in Siblings, and Absent in Patients With Psychotic Disorder. Schizophrenia Bulletin, 43(2), 316-324.
  • Van Os J, Van Der Steen Y, Islam MA, Guloksuz S, Rutten BP, Simons CJ, GROUP Investigators (2017). Evidence that polygenic risk for psychotic disorder is expressed in the domain of neurodevelopment, emotion regulation and attribution of salience. Psychological Medicine, 47(14), 2421-2437.
  • Van Os, J. & Güloksuz, S. (2017). A critique of the popular “ultra-high risk” and “transition” paradigm in psychiatry. World Psychiatry,16, 200-206
  • Van Os, J., Verhagen, S., Marsman, et al. (2017) The Experience Sampling Method as an mHealth Tool to Support Self-monitoring, Self-Insight and Personalised Health Care in Clinical Practice. Depression and Anxiety, 34(6), 481-493.

Strategic program(s):

Contact

Research groups

Innovation in psychiatry

Research aim

Innovation in Psychiatry embraces patient involvement, use different data sources and tools & methods for personalized prediction and treatment. With a holistic approach, we aim to improve the well-being of individuals with mental health problems.

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Recent publications

Decision-making on an AI-supported youth mental health app Dorothee Horstkötter, Mariël Kanne, Simona Karbouniaris, Noussair Lazrak, Maria Bulgheroni, Ella Sheltawy, Laura Giani, Margherita La Gamba, Esmeralda Ruiz Pujadas, Marina Camacho, Finty Royle, Irene Baggetto, Sinan Gülöksüz, Bart Rutten, Jim van Os
Journal of Responsible Technology, 2025, vol. 22
Sex and age effects on prevalence of CYP2C19 and CYP2D6 Phenoconversion risk over time in patients with psychosis Emma Y. De Brabander, Nicole K. Leibold, Thérèse van Amelsvoort, Roos van Westrhenen, Behrooz Z. Alizadeh, Wiepke Cahn, Lieuwe de Haan, Marieke van der Pluijm, Claudia J.P. Simons, Jim van Os, Wim Veling,
Progress in Neuro-Psychopharmacology and Biological Psychiatry, 2025, vol. 138
Symptom networks of psychotic experiences and functional somatic symptoms in adolescence Martin Køster Rimvall, Spyros Balafas, Charlotte Ulrikka Rask, Ernst C. Wit, Judith G.M. Rosmalen, Frank Verhulst, Jim van Os, Johanna T.W. Wigman, Pia Jeppesen
Schizophrenia Research, 2025, vol. 279, p.128-136
What Do Four Decades of Research Tell Us About the Association Between Childhood Adversity and Psychosis Lan Zhou, Iris E C Sommer, Pengyuan Yang, Lev Sikirin, Jim van Os, Richard P Bentall, Filippo Varese, Marieke J H Begemann
American Journal of Psychiatry, 2025, vol. 182, p.360-372
Association between Adverse Childhood Experiences and long-term outcomes in people at Clinical High-Risk for Psychosis Stefania Tognin, Ana Catalan, Claudia Aymerich, Anja Richter, Matthew J. Kempton, Gemma Modinos, Ryan Hammoud, Iñigo Gorostiza, Evangelos Vassos, Mark van der Gaag, Lieuwe de Haan, Barnaby Nelson, Anita Riecher-Rössler, Rodrigo Bressan, Neus Barrantes-Vidal, Marie Odile Krebs, Merete Nordentoft, Stephan Ruhrmann, Gabriele Sachs, Bart P. Rutten, Jim van Os, Philippe A. Delespaul, Bernadette Winklbaur, Iris Lasser, Joachim Klosterkötter, Julia Arnhold, Dominika Gebhard, Stephan Ruhrmann, Birte Glenthøj, Louise Glenthøj, Kristine Krakauer, Lasse Randers, Dorte Nordholm, Célia Mam-Lam-Fook, Olivier Gay, Julie Bourgin, Claire Daban, Mathilde Kazes, Lídia Hinojosa, Manel Monsonet, Thomas R. Kwapil, Anna Racciopi, Tecelli Domínguez-Martínez, Andre Zugman, Elson Asevedo, Graccielle Asevedo, Elisa Brietzke, Ary Gadelha, Erich Studerus,
Schizophrenia, 2025, vol. 11
The Moderating Role of Genetic and Environmental Risk Factors for Schizophrenia on the Relationship between Autistic Traits and Psychosis Expression in the General Population Melike Karacam Dogan, Thanavadee Prachason, Bochao Lin, Lotta-Katrin Pries, Angelo Arias-Magnasco, Riccardo Bortoletto, Claudia Menne-Lothmann, Jeroen Decoster, Ruud van Winkel, Dina Collip, Philippe Delespaul, Marc De Hert, Catherine Derom, Evert Thiery, Nele Jacobs, Jim van Os, Bart Rutten, Natascia Brondino, Marco Colizzi, Jurjen Luykx, Laura Fusar-Poli, Sinan Guloksuz
Schizophrenia Bulletin Open, 2025, vol. 6

Fellowships & Awards

Ramaer Medal Outstanding Research, Dutch Psychiatric Association, 1997

Association of European Psychiatrists research price 2003 (20.000 euro)

Member, KNAW (2011).

Fellow, King’s College London (2016).

Thompson-Reuter WoS list of ‘most influential scientific minds’ and ‘highly cited researchers’

External positions

Voorzitter - Website psychosenet.nl in de lucht houden - Pilootproject ontwikkeling publieke ggz - Stichting PsychoseNet

Raad van Toezicht - None - Raad van Toezicht GGZ-VS Opleiding