Profile photo Jim van Os

Jim van Os

Full Professor

Strategic program(s):

Biography

I have a background in Epidemiology (London School of Hygiene and Tropical Medicine) and Psychiatry (Institute of Psychiatry, King’s College London). My research has focused on elucidating the nature of mental variation in relation to context, and identifying the interactions between environment and genetic liability driving this variation. Over the course of my career, I have developed a passion for making psychiatry more relevant for its users in terms of diagnostic practice, the use of scientific findings to create clinical impact, health service organization, teaching and co-creation with users. I think there is an urgent need to balance the discourse and the scientific focus of the psychiatric profession on the one hand, and the needs and wishes of patients and their relatives on the other. In my work as Neuroscience Division leader at MUMC and now UMCU, I have attempted to forge collaboration between the clinical neurosciences in order to create patient value, for example in the area of neuromodulation. After several decades of directing activities in health care and research, I think effective leadership is about facilitating others, creating a community and fostering the network – in the shared belief that our work serves to inspire students and impact the lives of patients.

Education

Basic Teaching Qualification, BROK certified

Ten most important scientific publications

  • Van Os, J., Hanssen, M., Bijl, R.V. & Vollebergh, W. (2001) Prevalence of psychotic disorder and community level of psychotic symptoms: an urban-rural comparison. Archives of General Psychiatry, 58, 663-668.

  • Van Os, J., Hanssen, M., Bak, M., et al (2003) Do urbanicity and familial liability coparticipate in causing psychosis? American Journal of Psychiatry, 160, 477-482.
  • Van Os, J., Altamura, A.C., Bobes, J. et al (2004) Evaluation of the Two-Way Communication Checklist as a clinical intervention. Results of a multinational, randomised controlled trial. British Journal of Psychiatry, 184, 79-83.
  • van Os, J. & Kapur, S. (2009) Schizophrenia. Lancet, 374, 635-645.
  • van Os, J., Kenis, G. & Rutten, B.P. (2010) The environment and schizophrenia. Nature, 468, 203-212.
  • van Os, J. & Reininghaus, U. (2016) Psychosis as a transdiagnostic and extended phenotype in the general population. World Psychiatry, 15, 118-124.
  • Van Os J, Marsman A, Van Dam D, Simons CJ, GROUP Investigators (2017). Evidence That the Impact of Childhood Trauma on IQ Is Substantial in Controls, Moderate in Siblings, and Absent in Patients With Psychotic Disorder. Schizophrenia Bulletin, 43(2), 316-324.
  • Van Os J, Van Der Steen Y, Islam MA, Guloksuz S, Rutten BP, Simons CJ, GROUP Investigators (2017). Evidence that polygenic risk for psychotic disorder is expressed in the domain of neurodevelopment, emotion regulation and attribution of salience. Psychological Medicine, 47(14), 2421-2437.
  • Van Os, J. & Güloksuz, S. (2017). A critique of the popular “ultra-high risk” and “transition” paradigm in psychiatry. World Psychiatry,16, 200-206
  • Van Os, J., Verhagen, S., Marsman, et al. (2017) The Experience Sampling Method as an mHealth Tool to Support Self-monitoring, Self-Insight and Personalised Health Care in Clinical Practice. Depression and Anxiety, 34(6), 481-493.

Strategic program(s):

Contact

Research groups

Innovation in psychiatry

Research aim

Innovation in Psychiatry embraces patient involvement, use different data sources and tools & methods for personalized prediction and treatment. With a holistic approach, we aim to improve the well-being of individuals with mental health problems.

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Recent publications

Association between Adverse Childhood Experiences and long-term outcomes in people at Clinical High-Risk for Psychosis Stefania Tognin, Ana Catalan, Claudia Aymerich, Anja Richter, Matthew J. Kempton, Gemma Modinos, Ryan Hammoud, Iñigo Gorostiza, Evangelos Vassos, Mark van der Gaag, Lieuwe de Haan, Barnaby Nelson, Anita Riecher-Rössler, Rodrigo Bressan, Neus Barrantes-Vidal, Marie Odile Krebs, Merete Nordentoft, Stephan Ruhrmann, Gabriele Sachs, Bart P. Rutten, Jim van Os, Philippe A. Delespaul, Bernadette Winklbaur, Iris Lasser, Joachim Klosterkötter, Julia Arnhold, Dominika Gebhard, Stephan Ruhrmann, Birte Glenthøj, Louise Glenthøj, Kristine Krakauer, Lasse Randers, Dorte Nordholm, Célia Mam-Lam-Fook, Olivier Gay, Julie Bourgin, Claire Daban, Mathilde Kazes, Lídia Hinojosa, Manel Monsonet, Thomas R. Kwapil, Anna Racciopi, Tecelli Domínguez-Martínez, Andre Zugman, Elson Asevedo, Graccielle Asevedo, Elisa Brietzke, Ary Gadelha, Erich Studerus,
Schizophrenia, 2025, vol. 11
Netwerkzorg Karin Hagoort, Jim J. van Os, Floortje E. Scheepers
Tijdschrift voor Psychiatrie, 2025, vol. 67, p.80-83
Independent and joint effects of genomic and exposomic loads for schizophrenia on psychotic experiences in adolescents of European ancestry Matteo Di Vincenzo, Thanavadee Prachason, Gaia Sampogna, Angelo Arias-Magnasco, Bochao Danae Lin, Lotta-Katrin Pries, Jim van Os, Bart P F Rutten, Ran Barzilay, Andrea Fiorillo, Sinan Guloksuz
Schizophrenia, 2025, vol. 11
Cognitive presentation at psychosis onset through premorbid deterioration and exposure to environmental risk factors Laura Ferraro, Marta Di Forti, Daniele La Barbera, Caterina La Cascia, Craig Morgan, Giada Tripoli, Hannah Jongsma, Fabio Seminerio, Crocettarachele Sartorio, Lucia Sideli, Ilaria Tarricone, Anna Lisa Carloni, Andrei Szoke, Baptiste Pignon, Miguel Bernardo, Lieuwe De Haan, Celso Arango, Eva Velthorst, Charlotte Gayer-Anderson, James Kirkbride, Bart P.F. Rutten, Antonio Lasalvia, Sarah Tosato, Cristina Marta Del Ben, Paulo Rossi Menezes, Julio Bobes, Manuel Arrojo, Andrea Tortelli, Peter Jones, Jean Paul Selten, Jim Van Os, Robin Murray, Diego Quattrone, Evangelos Vassos,
Psychological medicine, 2025, vol. 55
Long-term exposure therapy outcome in phobia and the link with behavioral and neural indices of extinction learning Jette H. de Vos, Iris Lange, Liesbet Goossens, Nicole K. Leibold, Klara de Cort, Jindra Bakker, Stijn Michielse, Machteld Marcelis, Jim van Os, Therese van Amelsvoort, David E.J. Linden, Koen R.J. Schruers
Journal of Affective Disorders, 2025, vol. 375, p.324-330
Further evidence for the association between childhood trauma and suicidal ideation in young individuals Nerea Moreno-Gamazo, Lotta Katrin Pries, Laia Marqués-Feixa, Sergi Papiol, Soledad Romero, Claudia Menne-Lothmann, Jeroen Decoster, Ruud van Winkel, Dina Collip, Philippe Delespaul, Marc De Hert, Catherine Derom, Evert Thiery, Nele Jacobs, Marieke Wichers, Jim van Os, Bart P.F. Rutten, Lourdes Fañanás, Sinan Guloksuz
Journal of Affective Disorders, 2025, vol. 370, p.118-123

Fellowships & Awards

Ramaer Medal Outstanding Research, Dutch Psychiatric Association, 1997

Association of European Psychiatrists research price 2003 (20.000 euro)

Member, KNAW (2011).

Fellow, King’s College London (2016).

Thompson-Reuter WoS list of ‘most influential scientific minds’ and ‘highly cited researchers’

External positions

Voorzitter - Website psychosenet.nl in de lucht houden - Pilootproject ontwikkeling publieke ggz - Stichting PsychoseNet

Raad van Toezicht - None - Raad van Toezicht GGZ-VS Opleiding