Profile photo Jeanette Leusen

Jeanette Leusen

Full Professor

Strategic program(s):

Biography

Prof. Jeanette Leusen, received her PhD in 1995 at the University of Amsterdam, The Netherlands. She became associate professor and head of the immunotherapy group of the University Medical Center in Utrecht in 2006, and head of the UMAB facility in 2012. She has co-authored more than 150 publications in peer-reviewed journals and is inventor on 13 patent applications. Her group of 24 FTE works on the mechanism of action of therapeutic antibodies, with a special interest in IgA as a novel class of antibody for the treatment of both malignant as infectious disease.

Research groups

Pediatric immunology team

Research aim

The pediatric immunology team focuses on the under-explored research field of immune response modification for the prevention of immune-driven diseases. The goal of our research is to develop interventions that can prevent disease manifestations.

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Antibody therapy

Research aim

In our research, we aim to understand antibodies in all aspects, from fundamental research to therapeutic applications including their mode of action, e.g. Fc receptors and complement, for cancer, auto immunity and infectious diseases.

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Recent publications

Sialylation inhibition improves macrophage mediated tumor cell phagocytosis of breast cancer cells triggered by therapeutic antibodies of different isotypes Marta Lustig, Christoph Hahn, Marie Leangen Herigstad, Jan Terje Andersen, Jeanette H W Leusen, Renate Burger, Thomas Valerius
Frontiers in oncology, 2024, vol. 14
Human breastmilk memory T cells throughout lactation manifest activated tissue-oriented profile with prominent regulation Elise S Saager, Arthur H van Stigt, Butstabong Lerkvaleekul, Lisanne Lutter, Anneke H Hellinga, M Marlot van der Wal, Louis J Bont, Jeanette Hw Leusen, Belinda Van't Land, Femke van Wijk,
JCI Insight, 2024, vol. 9
ITPK1 Sensitizes Tumor Cells to IgA-dependent Neutrophil Killing In Vivo Connor A Richterich, Meike E W Logtenberg, Marco J H Jansen, Mireille Toebes, Kaspar Bresser, Anne Borst, Anouk P Jurgens, Jeanette H W Leusen, Ton N Schumacher
Journal of immunology (Baltimore, Md. : 1950), 2024, vol. 213, p.1244-1254
Radiation response assessment of organoids derived from patients with pancreatic cancer Iris W.J.M. van Goor, Leon Raymakers, Daan S.H. Andel, Lodewijk A.A. Brosens, Onno Kranenburg, Jeanette H.W. Leusen, Gert J. Meijer, I. Quintus Molenaar, Hjalmar C. van Santvoort, J. H.Wilfred de Vries, Andre J.M. Wopereis, Martijn P.W. Intven, Lois A. Daamen
Clinical and translational radiation oncology, 2024, vol. 48
Enhancing neutrophil cytotoxicity of a panel of clinical EGFR antibodies by Fc engineering to IgA3.0 Chilam Chan, J. H.Marco Jansen, Ilona S.T. Hendriks, Ida C. van der Peet, Meggy E.L. Verdonschot, Elsemieke M. Passchier, Maria Tsioumpekou, Maaike Nederend, Sharon A. Klomp, Thomas Valerius, Matthias Peipp, Jeanette H.W. Leusen, Patricia A. Olofsen
MOLECULAR CANCER THERAPEUTICS, 2024, vol. 23, p.1317-1331
Enhancing IgA-mediated neutrophil cytotoxicity against neuroblastoma by CD47 blockade Chilam Chan, Marjolein Stip, Maaike Nederend, Marco Jansen, Elsemieke Passchier, Femke van den Ham, Judith Wienke, Geert van Tetering, Jeanette Leusen
Journal for ImmunoTherapy of Cancer, 2024, vol. 12

Fellowships & Awards

Dr Leusen holds several grants from Health Holland, KWF, Villa Joep! and industry.