Profile photo Jeanette Leusen

Jeanette Leusen

Full Professor

Strategic program(s):

Biography

Prof. Jeanette Leusen, received her PhD in 1995 at the University of Amsterdam, The Netherlands. She became associate professor and head of the immunotherapy group of the University Medical Center in Utrecht in 2006, and head of the UMAB facility in 2012. She has co-authored more than 150 publications in peer-reviewed journals and is inventor on 13 patent applications. Her group of 24 FTE works on the mechanism of action of therapeutic antibodies, with a special interest in IgA as a novel class of antibody for the treatment of both malignant as infectious disease.

Research groups

Pediatric immunology team

Research aim

The pediatric immunology team focuses on the under-explored research field of immune response modification for the prevention of immune-driven diseases. The goal of our research is to develop interventions that can prevent disease manifestations.

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Antibody therapy

Research aim

In our research, we aim to understand antibodies in all aspects, from fundamental research to therapeutic applications including their mode of action, e.g. Fc receptors and complement, for cancer, auto immunity and infectious diseases.

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Recent publications

The Efficacy of Targeted Monoclonal IgA Antibodies Against Pancreatic Ductal Adenocarcinoma Léon Raymakers, Elsemieke M Passchier, Meggy E L Verdonschot, Mitchell Evers, Chilam Chan, Karel C Kuijpers, G Mihaela Raicu, I Quintus Molenaar, Hjalmar C van Santvoort, Karin Strijbis, Martijn P W Intven, Lois A Daamen, Jeanette H W Leusen, Patricia A Olofsen
Cells, 2025, vol. 14
Complementing CD20 antibodies’ effector functions Jeanette Leusen, Thomas Valerius
Blood, 2025, vol. 145, p.1232-1234
Engineering of anticancer human immunoglobulin A equipped with albumin for enhanced plasma half-life Simone Mester, Chilam Chan, Marta Lustig, Stian Foss, J H Marco Jansen, Marie Leangen Herigstad, Mitchell Evers, Jeannette Nilsen, Karli R Reiding, J Mirjam A Damen, Renate Burger, Algirdas Grevys, Bjørn Dalhus, Thomas Valerius, Inger Sandlie, Jeanette H W Leusen, Jan Terje Andersen
PNAS nexus, 2025, vol. 4
Development and validation of a high throughput multiplex immunofluorescence assay to detect all human immunoglobulin isotypes and subclasses in human fluids Arthur H Van Stigt, Maaike Nederend, Gaby Smits, Marjan Kuijer, Rutger M Schepp, Pieter G Van Gageldonk, Anneke H Hellinga, Robert S Van Binnendijk, Louis J Bont, Belinda Van't Land, Gerco Den Hartog, Jeanette H W Leusen,
Journal of immunology (Baltimore, Md. : 1950), 2025, vol. 214, p.839–849
Sialylation inhibition improves macrophage mediated tumor cell phagocytosis of breast cancer cells triggered by therapeutic antibodies of different isotypes Marta Lustig, Christoph Hahn, Marie Leangen Herigstad, Jan Terje Andersen, Jeanette H W Leusen, Renate Burger, Thomas Valerius
Frontiers in oncology, 2024, vol. 14
Human breastmilk memory T cells throughout lactation manifest activated tissue-oriented profile with prominent regulation Elise S Saager, Arthur H van Stigt, Butstabong Lerkvaleekul, Lisanne Lutter, Anneke H Hellinga, M Marlot van der Wal, Louis J Bont, Jeanette Hw Leusen, Belinda Van't Land, Femke van Wijk,
JCI Insight, 2024, vol. 9

Fellowships & Awards

Dr Leusen holds several grants from Health Holland, KWF, Villa Joep! and industry.