Associate Professor
Strategic program(s):
Biography
The mission of my research is to use metabolic imaging in the diagnosis and treatment planning of metabolic disorders and cancer. I believe that direct measurement of tissue metabolism in the patient will lead to better understanding of the disease in the individual patient and can therefore faster translate to a change in diagnosis and consequently treatment, to better help the patient. I strive to invent and make available advanced metabolic imaging methods to aid diagnosis and treatment of the most vulnerable group of patients; children with metabolic diseases and solid tumours, who may greatly benefit from non-invasive metabolic characterisation of their disease.
I have a background in Biomedical Engineering and obtained my PhD in biomedicine on the topic of magnetic resonance spectroscopy (MRS) of human brain tumours at the Radboud University Nijmegen-Medical Centre. After a short post-doc position at the University Medical Centre Utrecht (UMCU) (Marina van Damma Grant), I obtained the Niels Stensen fellowship which enabled me to work as a postdoc to learn about pre-clinical research in oncology in the In-vivo Cellular and Molecular Imaging Center (ICMIC) from the department of radiology in the Johns Hopkins Medical Institutions, (Baltimore, USA) in 2011. I continued my post-doctoral research on advanced metabolic imaging methods at high magnetic field for human applications in the brain and body in the Leiden University Medical Centre and UMCU in 2012, and since 2019 as Associate Professor in the high field MR research group in the UCMU. Being part of this group, I have access to a large multidisciplinary team of experts on MRI and unique MRI equipment (7 Tesla MR system, MetaScanner). I guide and supervise master and PhD students in projects that make use of this equipment to study neurological diseases, metabolic diseases and cancer both in adults and children.
Research aim
Our research lines incorporate inventions of MR technology to be able to see the unseen for advancing medicine. Our clinical research focus areas are cancer, dementia, cardiovascular, stroke and MSK.Research aim
Our research lines incorporate inventions of MR technology to be able to see the unseen for advancing medicine. Our clinical research focus areas are cancer, dementia, cardiovascular, stroke and MSK.Research aim
We use longitudinal fetal and neonatal neuroimaging and neuromonitoring to study brain development and function, model brain diseases, and improve long term outcome in high-risk infants.2020: VIDI Silent MRI with the speed of CT and richer metabolic information than PET
2014: Saving breast cancer patients from ineffective cytotoxic treatment.
2013: VENI Towards non-invase metabolic imaging of breast cancer staging at 7 Tesla to guide treatments.
2010: Marina van Damme grant
2010: Monitoring of response to breast cancer therapy by 31P Magnetic Resonance Spectroscopy