Janetta Top

Assistant Professor

Strategic program(s):

Contact

jtop@umcutrecht.nl

Pure profile

Research groups

Microbial genomics and metagenomics

Research aim

We develop novel genomic methods for reconstructing and tracking antimicrobial resistance genes by building bioinformatics tools to facilitate data analysis of massive sequence data sets of pathogens and microbiomes.

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Translational microbiomics

Research aim

Our aim is to translate human microbiome knowledge to improved diagnostic tests and clinical interventions by incorporating systems biology into clinical epidemiological studies, conducting mechanistic laboratory studies, and linking the two.

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Recent publications

All publications

Gut microbiome and immune checkpoint inhibitor toxicity Rik J Verheijden, Mick J M van Eijs, Fernanda L Paganelli, Marco C Viveen, Malbert R C Rogers, Janetta Top, Anne M May, Janneke H H M van de Wijgert, Karijn P M Suijkerbuijk,
European Journal of Cancer, 2025, vol. 216

Omnigene-Gut^tm ensures fecal microbiome stability in the pediatric population Raoull Hoogendijk, Thijs J.M. van den Broek, Hyunju Lee, Sabine Mueller, Cassie Kline, John Bianco, Janetta Top, Marcel R. de Zoete, Lennart Kester, Friso Calkoen, Jasper van der Lugt
AMB Express, 2024, vol. 14

Next-generation IgA-SEQ allows for high-throughput, anaerobic, and metagenomic assessment of IgA-coated bacteria Merel van Gogh, Jonas M Louwers, Anna Celli, Sanne Gräve, Marco C Viveen, Sofie Bosch, Nanne K H de Boer, Rik J Verheijden, Karijn P M Suijkerbuijk, Eelco C Brand, Janetta Top, Bas Oldenburg, Marcel R de Zoete
Microbiome, 2024, vol. 12

YajC, a predicted membrane protein, promotes Enterococcus faecium biofilm formation in vitro and in a rat endocarditis model Janetta Top, Xinglin Zhang, Antoni P.A. Hendrickx, Sjef Boeren, Willem van Schaik, Johannes Huebner, Rob J.L. Willems, Helen L. Leavis, Fernanda L. Paganelli
FEMS Microbes, 2024, vol. 5

A novel pathogenic taxon of the Mycobacterium tuberculosis complex, Canetti D van Soolingen, T Hoogenboezem, P E de Haas, P W Hermans, M A Koedam, K S Teppema, P J Brennan, G S Besra, F Portaels, J Top, L M Schouls, J D van Embden
International journal of systematic bacteriology, 1997, vol. 47, p.1236-1245

Rapid typing of group A streptococci by the use of DNA amplification and non-radioactive allele-specific oligonucleotide probes A Kaufhold, A Podbielski, G Baumgarten, M Blokpoel, J Top, L Schouls
FEMS microbiology letters, 1994, vol. 119, p.19-25