Profile photo Jaap van Laar

Jaap van Laar

Full Professor

Biography

Jacob M. van Laar is Professor at the Department of Rheumatology and Clinical Immunology at UMC Utrecht, the Netherlands. After obtaining his MD and PhD degrees at Leiden University, he specialised in Internal Medicine and Rheumatology in Leiden University Medical Center and worked at the Department of Rheumatology as clinical academic in various roles from 1997-2007, interrupted by a postdoctoral research fellowship at the National Institute of Arthritis and Musculoskeletal and Skin Diseases in Bethesda, USA. From 2007 until 2013 he held a Chair in Clinical Rheumatology at Newcastle University, and post as honorary consultant rheumatologist at The James Cook University Hospital, Middlesbrough, UK. He has been working as Professor of Rheumatology at UMC Utrecht since 1 November 2013. His main research interests involve clinical and pathogenetic aspects of systemic sclerosis and rheumatoid arthritis, aimed at improving the outcome of patients with rheumatic diseases by innovative clinical-translational research.

Research groups

Rheumatology & clinical immunology

Research aim

To improve clinical practice by optimizing diagnosis, prognosis and treatment of rheumatic and immune-mediated and immune-deficient inflammatory diseases
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Pediatric immunology team

Research aim

The pediatric immunology team focuses on the under-explored research field of immune response modification for the prevention of immune-driven diseases. The goal of our research is to develop interventions that can prevent disease manifestations.
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Recent publications

Atosiban versus placebo in the treatment of threatened preterm birth between 30 and 34 weeks gestation Larissa Van Der Windt, Job Klumper, Emilie V.J. Van Limburg Stirum, Janneke Van 'T Hooft, Madelon Van Wely, Aleid G. Van Wassenaer-Leemhuis, Eva Pajkrt, Martijn A. Oudijk, M. A. De Boer, E. S.A. Van Den Akker, A. J.M. Huisjes, J. M. Sikkema, J. Schaaf, H. Visser, D. W.M. Papatsonis, J. J. Zwart, J. O.E.H. Van Laar, J. Baalman, K. S.J. Gordijn, D. P. Van Der Ham, K. C. Vollebregt, J. Langenveld, M. S. Post, M. Sueters, H. C.J. Scheepers, R. R. Scholten, N. Van Gemund, M. N. Bekker, Deurloo, M. Knol, F. McAuliffe, K. Walker,
BMJ Open, 2024, vol. 14
Author Correction: Regulatory T cells in psoriatic arthritis: an IL-17A-producing, Foxp3intCD161 + RORγt + ICOS + phenotype, that associates with the presence of ADAMTSL5 autoantibodies Juliëtte N. Pouw, Michel A.M. Olde Nordkamp, Tessa van Kempen, Arno N. Concepcion, Jacob M. van Laar, Femke van Wijk, Julia Spierings, Emmerik F.A. Leijten, Marianne Boes
Scientific Reports, 2023, vol. 13, p.1-1
Association of endothelial to mesenchymal transition and cellular senescence with fibrosis in skin biopsies of systemic sclerosis patients Yu Hsiang Chiu, Julia Spierings, Jacob M. van Laar, Jeska K. de Vries-Bouwstra, Marijke van Dijk, Roel Goldschmeding
Clinical and Experimental Rheumatology, 2023, vol. 41, p.1612-1617
Prognostication of progressive pulmonary fibrosis in connective tissue disease-associated interstitial lung diseases Yu Hsiang Chiu, Maaike F.M. Koops, Mareye Voortman, H. Wouter van Es, Lucianne C.M. Langezaal, Paco M.J. Welsing, Anna Jamnitski, Anne E. Wind, Jacob M. van Laar, Jan C. Grutters, Julia Spierings
Frontiers in medicine, 2023, vol. 10
Anti-thymocyte globulin exposure in patients with diffuse cutaneous systemic sclerosis undergoing autologous haematopoietic stem cell transplantation Yu Hsiang Chiu, Anouk Drijver, Rick Admiraal, Anna van Rhenen, Stefan Nierkens, Jacob M. van Laar, Julia Spierings
Journal of Scleroderma and Related Disorders, 2023, vol. 8, p.241-246
Concomitant prednisone may alleviate methotrexate side-effects in rheumatoid arthritis patients Matthijs S. van der Leeuw, Janneke Tekstra, Jacob M. van Laar, Paco M.J. Welsing
BMC Rheumatology, 2023, vol. 7

External positions

The James Cook University Hospital

Department of Rheumatology, LUMC