Profile photo Harrie Weinans

Harrie Weinans

Associate Professor

Strategic program(s):

Biography

Our stiff bones are held together by ligaments and tendons and carry the weight and transfer the large forces that are required for locomotion. Without these load bearing mechanical tissues we would look like a gelatin pudding. With aging or after trauma the delicate internal architecture of these connective tissues gets lost, which can result in e.g. cartilage damage and subsequent deterioration (osteoarthritis), loss of bone mass (osteoporosis) problematic healing of fractures or tendons. Bone and cartilage are load bearing structures and degeneration and regeneration in these tissues are continuously influenced by and adapted to the biomechanical demands. The major goal of my research is to investigate the degenerative processes in the skeletal structures and find methods to counterbalance this degeneration or even induce appropriate regeneration after the tissue is already diminished.

Harrie Weinans is minority shareholder of Uplanner BV and Replasia BV

Research groups

Utrecht Osteoarthritis Research - UROAR

Research aim

Our group studies osteoarthritis, from disease mechanisms to treatment strategies. Using a translational approach, we connect lab research to patient care, aiming to create effective diagnostic tools and patient-centered therapies.

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Recent publications

The Impact of varus and valgus alignment on knee cartilage quality assessed by magnetic resonance imaging Eva A. Bax, Joost A.J. Kerkhof, Nienke van Egmond, Ruurd J.A. Kuiper, Hassan Rayegan, Margreet Kloppenburg, Francisco J. Blanco, Ida K. Haugen, Francis Berenbaum, Simon C. Mastbergen, Felix Eckstein, Wolfgang Wirth, Frank W. Roemer, Moyo C. Kruyt, Harrie Weinans, Roel J.H. Custers
Knee, 2025, vol. 57, p.477-487
Digitally Designed Bone; A 3D-patient-specific Allograft Shelf for Severe Adolescent Hip Dysplasia Erik M van Bussel, Jafar Nasrabadi, Joëll Magré, Vahid Arbabi, Koen Willemsen, Bart J Kaptein, Bjorn P Meij, Marianna A Tryfonidou, Bart C H van der Wal, Harrie H Weinans, Ralph J B Sakkers
Journal of the American Academy of Orthopaedic Surgeons Global Research and Reviews, 2025, vol. 9
Deep Learning Based Automatic Ankle Tenosynovitis Quantification from MRI in Patients with Psoriatic Arthritis Saeed Arbabi, Vahid Arbabi, Lorenzo Costa, Iris Ten Katen, Simon C Mastbergen, Peter R Seevinck, Pim A de Jong, Harrie Weinans, Mylène P Jansen, Wouter Foppen
Diagnostics, 2025, vol. 15
Mixtures of PRR Ligands Partly Mimic the Immunomodulatory Response of γi Staphylococcus aureus, Enhancing Osteogenic Differentiation of Human Mesenchymal Stromal Cells Paree Khokhani, Kelly Warmink, Moyo Kruyt, Harrie Weinans, Debby Gawlitta
Stem Cells International, 2025, vol. 2025
Ultrasound-based statistical shape modeling for prognosis in unstable hip dysplasia E. M. van Bussel, L. van Marle, J. M. Bonsel, D. de Vrij, H. Weinans, R. Sakkers
Ultrasound Journal, 2025, vol. 17
Antibody and aptamer-based therapies for osteoarthritis Huaizhi Chen, Zijian Ye, Jasmijn V. Korpershoek, Laura B. Creemers, Harrie Weinans, Jaqueline Lourdes Rios
Molecular therapy. Nucleic acids, 2025, vol. 36

External positions

HL, 1 dag per week - colleges, begeleiding afstudeerprojecten, research - TU Delft