Roel Goldschmeding

Assistant Professor - medical

Contact

rgoldsch@umcutrecht.nl

Pure profile

Research groups

Cardiovascular and kidney pathology

Research aim

We focus on patient-centered research into kidney diseases. We employ techniques such as immunohistochemistry, cell biology, model systems, microscopy, and MALDI mass spectrometry imaging. Additionally, we employ AI tools for digital pathology.

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Recent publications

All publications

CCN2/CTGF expression does not correlate with fibrosis in myeloproliferative neoplasms, consistent with noncanonical TGF-β signaling driving myelofibrosis Roos J Leguit, Roel Broekhuizen, Moniek de Witte, Reinier A P Raymakers, Roel Goldschmeding
Virchows Archives, 2024, vol. 484, p.837-845

Association of endothelial to mesenchymal transition and cellular senescence with fibrosis in skin biopsies of systemic sclerosis patients Yu Hsiang Chiu, Julia Spierings, Jacob M. van Laar, Jeska K. de Vries-Bouwstra, Marijke van Dijk, Roel Goldschmeding
Clinical and Experimental Rheumatology, 2023, vol. 41, p.1612-1617

Tacrolimus induces a pro-fibrotic response in donor-derived human proximal tubule cells dependent on common variants of the CYP3A5 and ABCB1 genes Noël Knops, Yasaman Ramazani, Henriëtte De Loor, Roel Goldschmeding, Tri Q Nguyen, Lambert P van den Heuvel, Elena Levtchenko, Dirk J Kuypers
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, 2023, vol. 38, p.599-609

Cellular senescence in kidney biopsies is associated with tubular dysfunction and predicts CKD progression in childhood cancer patients with karyomegalic interstitial nephropathy Sebastiaan N Knoppert, Mandy G Keijzer-Veen, Floris A Valentijn, Marry M van den Heuvel-Eibrink, Marc R Lilien, Gerrit van den Berg, Lianne M Haveman, Marijn F Stokman, Geert O Janssens, Sven van Kempen, Roel Broekhuizen, Roel Goldschmeding, Tri Q Nguyen
Journal of Pathology, 2023, vol. 261, p.455-464

CCN2 Activates RIPK3, NLRP3 Inflammasome, and NRF2/Oxidative Pathways Linked to Kidney Inflammation Sandra Rayego-Mateos, Laura Marquez-Exposito, Pamela Basantes, Lucia Tejedor-Santamaria, Ana B Sanz, Tri Q Nguyen, Roel Goldschmeding, Alberto Ortiz, Marta Ruiz-Ortega
Antioxidants (Basel, Switzerland), 2023, vol. 12

Spontaneous Complete Regression of Colon Cancer Liver Metastases in a Lung Transplant Patient Koen Zwart, Dieuwertje Ruigrok, Magda de Graaf-Bos, Roel Goldschmeding, Miriam Koopman, Guus M Bol
Case reports in transplantation, 2023, vol. 2023