Roel Goldschmeding

Assistant Professor - medical

Contact

rgoldsch@umcutrecht.nl

Pure profile

Research groups

Cardiovascular and kidney pathology

Research aim

We focus on patient-centered research into kidney diseases. We employ techniques such as immunohistochemistry, cell biology, model systems, microscopy, and MALDI mass spectrometry imaging. Additionally, we employ AI tools for digital pathology.

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Recent publications

All publications

CCN2 Activates Cellular Senescence Leading to Kidney Fibrosis in Folic Acid-Induced Experimental Nephropathy Lucia Tejedor-Santamaria, Laura Marquez-Exposito, Alicia Villacampa, Vanessa Marchant, Antonio Battaglia-Vieni, Sandra Rayego-Mateos, Raul R Rodrigues-Diez, Fatima Milhano Santos, Floris A Valentijn, Sebastian N Knoppert, Roel Broekhuizen, María Piedad Ruiz-Torres, Roel Goldschmeding, Alberto Ortiz, Concepción Peiró, Tri Q Nguyen, Adrián M Ramos, Marta Ruiz-Ortega
International Journal of Molecular Sciences, 2025, vol. 26

Smooth muscle-specific deletion of Ccn2 causes severe aorta malformation and atherosclerosis Jannik H Larsen, Julie S Hegelund, Matilde K Pedersen, Cecilie M Andersson, Caroline A Lindegaard, Didde R Hansen, Jane Stubbe, Jes S Lindholt, Camilla S Hansen, Andrietta Grentzmann, Maria Bloksgaard, Boye L Jensen, Raúl R Rodriguez-Díez, Marta Ruiz-Ortega, Sebastian Albinsson, Gerard Pasterkamp, Michal Mokry, Andrew Leask, Roel Goldschmeding, Bartosz Pilecki, Grith L Sorensen, Charles Pyke, Martin Overgaard, Hans C Beck, Daniel F J Ketelhuth, Lars M Rasmussen, Lasse B Steffensen
Cardiovascular research, 2024, vol. 120, p.1851–1868

Author Correction C van Dooijeweert, R N Flach, N D Ter Hoeve, C P H Vreuls, R Goldschmeding, J E Freund, P Pham, T Q Nguyen, E van der Wall, G W J Frederix, N Stathonikos, P J van Diest
Nature Cancer, 2024, vol. 5

Clinical implementation of artificial-intelligence-assisted detection of breast cancer metastases in sentinel lymph nodes C van Dooijeweert, R N Flach, N D Ter Hoeve, C P H Vreuls, R Goldschmeding, J E Freund, P Pham, T Q Nguyen, E van der Wall, G W J Frederix, N Stathonikos, P J van Diest
Nature Cancer, 2024, vol. 5, p.1195-1205

CCN2/CTGF expression does not correlate with fibrosis in myeloproliferative neoplasms, consistent with noncanonical TGF-β signaling driving myelofibrosis Roos J Leguit, Roel Broekhuizen, Moniek de Witte, Reinier A P Raymakers, Roel Goldschmeding
Virchows Archives, 2024, vol. 484, p.837-845

CCN2 Activates RIPK3, NLRP3 Inflammasome, and NRF2/Oxidative Pathways Linked to Kidney Inflammation Sandra Rayego-Mateos, Laura Marquez-Exposito, Pamela Basantes, Lucia Tejedor-Santamaria, Ana B Sanz, Tri Q Nguyen, Roel Goldschmeding, Alberto Ortiz, Marta Ruiz-Ortega
Antioxidants (Basel, Switzerland), 2023, vol. 12

External positions

Supervisie dierexperiment - Wetenschap - Fibrogen Inc