Martijn Gloerich

Associate Professor

Strategic program(s):

Contact

mgloeric@umcutrecht.nl

Pure profile

Research groups

Mechanobiology of epithelial homeostasis and cancer

Research aim

Our aim is to elucidate how cells respond to mechanical forces to control healthy epithelial homeostasis, and to understand how alterations in force-dependent communication contribute to tumor development.

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Recent publications

All publications

Intestinal tuft cell subtypes represent successive stages of maturation driven by crypt-villus signaling gradients Julian R Buissant des Amorie, Max A Betjes, Jochem H Bernink, Joris H Hageman, Veerle E Geurts, Harry Begthel, Dimitrios Laskaris, Maria C Heinz, Ingrid Jordens, Tiba Vinck, Ronja M Houtekamer, Ingrid Verlaan-Klink, Sascha R Brunner, Jacco van Rheenen, Martijn Gloerich, Hans Clevers, Sander J Tans, Jeroen S van Zon, Hugo J G Snippert
Nature Communications, 2025, vol. 16

E-cadherin mechanotransduction activates EGFR-ERK signaling in epithelial monolayers by inducing ADAM-mediated ligand shedding Ronja M Houtekamer, Mirjam C van der Net, Marjolein J Vliem, Tomas E J C Noordzij, Lisa van Uden, Robert M van Es, Joo Yong Sim, Eriko Deguchi, Kenta Terai, Matthew A Hopcroft, Harmjan R Vos, Beth L Pruitt, Michiyuki Matsuda, Willem-Jan Pannekoek, Martijn Gloerich
Science Signaling [E], 2025, vol. 18

Tumour-intrinsic alterations and stromal matrix remodelling promote Wnt-niche independence during diffuse-type gastric cancer progression Lars J S Kemp, Jooske L Monster, Colin S Wood, Martijn Moers, Marjolein J Vliem, Antoine A Khalil, Nigel B Jamieson, Lodewijk A A Brosens, Liudmila L Kodach, Jolanda M van Dieren, Tanya M Bisseling, Rachel S van der Post, Martijn Gloerich
Gut, 2025, vol. 74, p.1219-1229

PIEZO-dependent mechanosensing is essential for intestinal stem cell fate decision and maintenance Meryem B. Baghdadi, Ronja M. Houtekamer, Louisiane Perrin, Abilasha Rao-Bhatia, Myles Whelen, Linda Decker, Martin Bergert, Carlos Pérez-Gonzàlez, Réda Bouras, Giacomo Gropplero, Adrian K.H. Loe, Amin Afkhami-Poostchi, Xin Chen, Xi Huang, Stephanie Descroix, Jeffrey L. Wrana, Alba Diz-Muñoz, Martijn Gloerich, Arshad Ayyaz, Danijela Matic Vignjevic, Tae Hee Kim
Science (New York, N.Y.), 2024, vol. 386

Cell division-dependent dissemination following E-cadherin loss underlies initiation of diffuse-type gastric cancer Jooske L Monster, Lars Js Kemp, Georg A Busslinger, Marjolein J Vliem, Lucca Lm Derks, Annelot Al Staes, Tanya M Bisseling, Hans Clevers, Rachel S van der Post, Martijn Gloerich
Journal of Pathology, 2024, vol. 263, p.226-241

Co-cultures of colon cancer cells and cancer-associated fibroblasts recapitulate the aggressive features of mesenchymal-like colon cancer Esther Strating, Mathijs P Verhagen, Emerens Wensink, Ester Dünnebach, Liza Wijler, Itziar Aranguren, Alberto Sanchez De la Cruz, Niek A Peters, Joris H Hageman, Mirjam M C van der Net, Susanne van Schelven, Jamila Laoukili, Riccardo Fodde, Jeanine Roodhart, Stefan Nierkens, Hugo Snippert, Martijn Gloerich, Inne Borel Rinkes, Sjoerd G Elias, Onno Kranenburg
Frontiers in Immunology, 2023, vol. 14