Martijn Gloerich

Associate Professor

Strategic program(s):

Contact

mgloeric@umcutrecht.nl

Pure profile

Research groups

Mechanobiology of epithelial homeostasis and cancer

Research aim

Our aim is to elucidate how cells respond to mechanical forces to control healthy epithelial homeostasis, and to understand how alterations in force-dependent communication contribute to tumor development.

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Recent publications

All publications

Cell division-dependent dissemination following E-cadherin loss underlies initiation of diffuse-type gastric cancer Jooske L Monster, Lars Js Kemp, Georg A Busslinger, Marjolein J Vliem, Lucca Lm Derks, Annelot Al Staes, Tanya M Bisseling, Hans Clevers, Rachel S van der Post, Martijn Gloerich
Journal of Pathology, 2024, vol. 263, p.226-241

PIEZO-dependent mechanosensing is essential for intestinal stem cell fate decision and maintenance Meryem B. Baghdadi, Ronja M. Houtekamer, Louisiane Perrin, Abilasha Rao-Bhatia, Myles Whelen, Linda Decker, Martin Bergert, Carlos Pérez-Gonzàlez, Réda Bouras, Giacomo Gropplero, Adrian K.H. Loe, Amin Afkhami-Poostchi, Xin Chen, Xi Huang, Stephanie Descroix, Jeffrey L. Wrana, Alba Diz-Muñoz, Martijn Gloerich, Arshad Ayyaz, Danijela Matic Vignjevic, Tae Hee Kim
Science (New York, N.Y.), 2024, vol. 386

Co-cultures of colon cancer cells and cancer-associated fibroblasts recapitulate the aggressive features of mesenchymal-like colon cancer Esther Strating, Mathijs P Verhagen, Emerens Wensink, Ester Dünnebach, Liza Wijler, Itziar Aranguren, Alberto Sanchez De la Cruz, Niek A Peters, Joris H Hageman, Mirjam M C van der Net, Susanne van Schelven, Jamila Laoukili, Riccardo Fodde, Jeanine Roodhart, Stefan Nierkens, Hugo Snippert, Martijn Gloerich, Inne Borel Rinkes, Sjoerd G Elias, Onno Kranenburg
Frontiers in Immunology, 2023, vol. 14

Cell division orientation is coupled to cell-cell adhesion by the E-cadherin/LGN complex Martijn Gloerich, Julie M. Bianchini, Kathleen A. Siemers, Daniel J. Cohen, W. James Nelson
Nature Communications [E], 2017, vol. 8

E-cadherin and LGN align epithelial cell divisions with tissue tension independently of cell shape Kevin C Hart, Jiongyi Tan, Kathleen A Siemers, Joo Yong Sim, Beth L Pruitt, W James Nelson, Martijn Gloerich
Proceedings of the National Academy of Sciences of the United States of America, 2017, vol. 114, p.E5845-E5853

Epithelial self-healing is recapitulated by a 3D biomimetic E-cadherin junction Daniel J. Cohen, Martijn Gloerich, W. James Nelson
Proceedings of the National Academy of Sciences of the United States of America, 2016, vol. 113, p.14698-14703