Martijn Gloerich

Associate Professor

Strategic program(s):

Contact

mgloeric@umcutrecht.nl

Pure profile

Research groups

Mechanobiology of epithelial homeostasis and cancer

Research aim

Our aim is to elucidate how cells respond to mechanical forces to control healthy epithelial homeostasis, and to understand how alterations in force-dependent communication contribute to tumor development.

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Recent publications

All publications

Cell division-dependent dissemination following E-cadherin loss underlies initiation of diffuse-type gastric cancer Jooske L Monster, Lars Js Kemp, Georg A Busslinger, Marjolein J Vliem, Lucca Lm Derks, Annelot Al Staes, Tanya M Bisseling, Hans Clevers, Rachel S van der Post, Martijn Gloerich
Journal of Pathology, 2024, vol. 263, p.226-241

Co-cultures of colon cancer cells and cancer-associated fibroblasts recapitulate the aggressive features of mesenchymal-like colon cancer Esther Strating, Mathijs P Verhagen, Emerens Wensink, Ester Dünnebach, Liza Wijler, Itziar Aranguren, Alberto Sanchez De la Cruz, Niek A Peters, Joris H Hageman, Mirjam M C van der Net, Susanne van Schelven, Jamila Laoukili, Riccardo Fodde, Jeanine Roodhart, Stefan Nierkens, Hugo Snippert, Martijn Gloerich, Inne Borel Rinkes, Sjoerd G Elias, Onno Kranenburg
Frontiers in Immunology, 2023, vol. 14

Cell division orientation is coupled to cell-cell adhesion by the E-cadherin/LGN complex Martijn Gloerich, Julie M. Bianchini, Kathleen A. Siemers, Daniel J. Cohen, W. James Nelson
Nature Communications [E], 2017, vol. 8

Epithelial self-healing is recapitulated by a 3D biomimetic E-cadherin junction Daniel J. Cohen, Martijn Gloerich, W. James Nelson
Proceedings of the National Academy of Sciences of the United States of America, 2016, vol. 113, p.14698-14703

Rap2A links intestinal cell polarity to brush border formation M. Gloerich, J.P. ten Klooster, M.J. Vliem, T. Koorman, G.J.T. Zwartkruis, H. Clevers, J.L. Bos
Nature Cell Biology, 2012, vol. 14, p.793-801

cAMP regulates DEP domain-mediated binding of the guanine nucleotide exchange factor Epac1 to phosphatidic acid at the plasma membrane S.V. Consonni, M. Gloerich, E. Spanjaard, J.L. Bos
Proceedings of the National Academy of Sciences of the United States of America, 2012, vol. 109, p.3814-3819