Frank Meye

Associate Professor

Strategic program(s):

Biography

Neurophysiologist doing research on the brain's reward system in health and disease. Current focus on effects of stress on the (extended) dopamine neural circuitry, in relation to obesity, eating disorders and drug addiction.

Strategic program(s):

Contact

fmeye2@umcutrecht.nl

Pure profile

Research groups

Neural circuit plasticity and function

Research aim

The brain performs its functions through neural circuits: collections of interconnected cells (i.e. different types of neurons, and glial cells). We aim to unravel these circuits, understand how experiences alter them, and decipher their function.

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Neural circuit function

Research aim

We aim to unravel the neurobiology underlying eating disorders. This will provide a framework for the development of neurobiology-based therapeutic interventions for diseases like anorexia nervosa.

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Recent publications

All publications

Reduced Ventral Tegmental Area GABA neuron output contributes to hyperactivity in the activity-based anorexia model in female mice Fabien Ducrocq, Lianne Delwel, Nick Papavoine, Eileen Brouwer, Karlijn L Kooij, Inge G Wolterink-Donselaar, Lisa Drost, Jaimie Hak, Melissa Veendijk, Mieneke C M Luijendijk, Frank J Meye, Roger A H Adan
Nature Communications, 2025, vol. 17

Comparative gene editing reduces dopamine receptor levels across rodent species Sonia C Karkare, Dario Aspesi, Keith M Garner, Evelien H S Schut, H Elliott Albers, Frank J Meye, Malavika Murugan, Arjen J Boender
2025

Neuropeptide Y neurons surrounding the locus coeruleus inhibit noradrenergic system activity to reduce anxiety Danai Riga, Karlijn L. Kooij, Kelly Rademakers, Inge G. Wolterink-Donselaar, Onur Basak, Frank J. Meye
Science advances, 2025, vol. 11

Neuropeptides as transmitters and regulators of the locus coeruleus noradrenergic system Léa J Becker, Madison M Martin, Alex C Hughes, Bernard Mulvey, Chao-Cheng Kuo, Sean C Piantadosi, Michael R Bruchas, Keri Martinowich, Frank J Meye, Lindsay A Schwarz, David Weinshenker, Jordan G McCall, Danai Riga
Pharmacological Reviews, 2025, vol. 77

Distinct ventral tegmental area neuronal ensembles are indispensable for reward-driven approach and stress-driven avoidance behaviors Ioannis Koutlas, Lefkothea Patrikiou, Stef E. van der Starre, Diaz Danko, Inge G. Wolterink-Donselaar, Mieneke C.M. Luijendijk, Roger A.H. Adan, Frank J. Meye
Nature Communications, 2025, vol. 16

Identifying Patient Subgroups in the Heterogeneous Chronic Pain Population Using Cluster Analysis Mienke Rijsdijk, Hidde M Smits, Hazal R Azizoglu, Sylvia Brugman, Yoeri van de Burgt, Tessa C van Charldorp, Dewi J van Gelder, Janny C de Grauw, Eline A van Lange, Frank J Meye, Madelijn Strick, Hedi W A Walravens, Laura H H Winkens, Frank J P M Huygen, Julia Drylewicz, Hanneke L D M Willemen
The Journal of Pain, 2025, vol. 28

Fellowships & Awards

2021: Recipient of NWO VIDI
2019: Co-Recipient of NWO Gravity Grant
2019: Co-Recipient of Young IBRO Connecting Regions Grant
2019: Recipient of CJ Vaillant Grant
2018: Recipient of European Research Council (ERC) Starting Grant
2017: Recipient of Rudolf Magnus Young Talent award
2016: Recipient of NARSAD Young Investigator award BBR Foundation
2015: Recipient of VENI grant from Netherlands Organisation for Scientific Research
2012: Recipient of Fondation Fyssen postdoctoral scholarship

External positions

Lid Commissie ZonMW Open Competitie - Beoordeling van biomedische onderzoeksvoorstellen (raakvlak is dat ik biomedisch onderzoeker ben). - ZonMW