Profile photo Femke van Wijk

Femke van Wijk

Full Professor

Strategic program(s):

Biography

Dr. van Wijk obtained her PhD on mechanisms of oral tolerance and allergic sensitization to peanut at the Utrecht University in 2006. After her first postdoctoral training in human immunology in the lab of Prof. B. Prakken at the UMCU she obtained a KNAW fellowship for a 2-year postdoc in the lab of Prof. H. Cheroutre in the La Jolla Institute for Immunology in La Jolla (USA) to work on tissue T cell adaptation . After being awarded a VENI personal fellowship, she moved to the UMCU to start her own research group. For her research on how antigen presenting cells sabotage T cell regulation in local inflammation van Wijk was awarded a prestigious ZonMw VIDI career development grant (2014), and in 2021 she received a ZonMw VICI grant for her work on naïve T cell imprinting and immune development. Her research program aims to elucidate tissue T cell responses in health and inflammation and to translate these insights into tools for (pre-clinical) disease monitoring and therapeutic targeting in chronic inflammatory diseases.  She takes a disease- and age-overarching approach to decipher common and specific pathogenic processes underlying different inflammatory conditions and one of her specific interests is early imprinting of disease. Diseases her group is working on include atopic dermatitis, inflammatory bowel disease, juvenile idiopathic arthritis, juvenile dermatomyositis and immune toxicity following immune therapy in cancer.

 Dr. van Wijk is the author of >100 publications in leading peer-reviewed journals and has extensive experience with national and international scientific advisory committees (NWO off-road program, samenwerkende gezondheidsfondsen PPS Immunology consortia, Sanofi type 2 innovation grant, EU Horizon 2020 REA-FET-OPEN and COFUND). She is participating in several international networks including T_CELL_CONNECT_EUROPE, Eureka Institute for Translational Medicine, and Understanding Childhood Arthritis Worldwide Network that are aimed at (international) exchanges and training of young scientists, knowledge sharing, and enhancing reproducibility of human data. In 2017 Dr. van Wijk received the PhD supervisor of the year award by the Utrecht University Graduate School of Life Sciences.

Dr. van Wijk is also manager research for the division paediatrics at the UMCU , and scientific director FOCIS (federation of clinical immunology societies) center of excellence.

Research groups

Inflammatory bowel diseases

Research aim

Our research is focused on the elucidation of the pathogenesis of Inflammatory bowel diseases (IBD), personalized medicine and on a severe complication of IBD: colitis-associated colorectal carcinoma.
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Tissue immunology

Research aim

Our mission is to comprehensively understand, monitor, and target immune-mediated inflammatory diseases such as IBD, AD and systemic autoimmune diseases. We aim to unravel (tissue) immune dysregulation and induce long-lasting disease modification.
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Primary immunodeficiency

Research aim

To address unmet medical needs by detecting novel primary immunodeficiency, and improving clinical practice by optimizing diagnosis, prognosis and treatment of disease.
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Recent publications

Blood and tissue correlates of steroid non-response in checkpoint inhibition-induced immune-related adverse events Mick J M van Eijs, M Marlot van der Wal, Hedi-Britt Klotškova, Noël M M Dautzenberg, Mark Schuiveling, Rik J Verheijden, Fiona D M van Schaik, Bas Oldenburg, Stefan Nierkens, Karijn P M Suijkerbuijk, Femke van Wijk,
Communications medicine, 2025, vol. 5, p.1-14
Mucosal Kinase Activity and Inflammatory Profiles in Inflammatory Bowel Disease, and in Relation with Tofacitinib Response Eelco C Brand, Britt Roosenboom, Lisanne Lutter, Bea Malvar Fernandez, Savithri Rangarajan, Elly Van Koolwijk, Sara Van Gennep, Geert R D'Haens, Ellen G Van Lochem, Carmen S Horjus Talabur Horje, Kris A Reedquist, Femke Van Wijk, Bas Oldenburg
Journal of Crohn's & Colitis, 2025, vol. 19
Advances in juvenile dermatomyositis Saskia R Veldkamp, Laura van der Griend, Elsbeth Noppers, Wineke Armbrust, J Merlijn van den Berg, Petra C E Hissink Muller, Esther Hoppenreijs, Sylvia Kamphuis, Judith Wienke, Femke van Wijk, Annet van Royen-Kerkhof, Marc H A Jansen
Rheumatology (Oxford, England), 2025, vol. 64, p.5622–5628
Measurement of Tralokinumab Concentrations in Serum and Tear Fluid of Atopic Dermatitis Patients and the Relationship With Treatment Response and Ocular Surface Disease Coco Dekkers, Erin H Smeijsters, Mohsin El Amrani, Constance den Hartog Jager, Kim C M van der Elst, Matthijs van Luin, Chantal van Luijk, Daphne S Bakker, Alwin D R Huitema, Marlies de Graaf, Femke van Wijk, Marjolein S de Bruin-Weller
Clinical and Experimental Allergy, 2025, vol. 55, p.1156-1160
Targeting interferon responses in juvenile dermatomyositis Saskia R Veldkamp, Maud Reugebrink, Sanne W Evers, Thomas R J Moreau, Vincent Bondet, Wineke Armbrust, J Merlijn van den Berg, Petra C E Hissink Muller, Sylvia Kamphuis, Ellen Schatorjé, Eveline M Delemarre, Anneke J van der Kooi, Brigitte Bader-Meunier, Darragh Duffy, Mathieu P Rodero, Joost Raaphorst, Annet van Royen-Kerkhof, Marc H A Jansen, Femke van Wijk
Rheumatology (Oxford, England), 2025, vol. 64, p.5132-5141
Imaging flow cytometry-based cellular screening elucidates pathophysiology in individuals with Variants of Uncertain Significance Irena Josephina Johanna Muffels, Hans R. Waterham, Giuseppina D’Alessandro, Guido Zagnoli-Vieira, Michael Sacher, Dirk J. Lefeber, Celine Van der Vinne, Chaim M. Roifman, Koen L.I. Gassen, Holger Rehmann, Desiree Y. Van Haaften-Visser, Edward S.S. Nieuwenhuis, Stephen P. Jackson, Sabine A. Fuchs, Femke Wijk, Peter van Hasselt
Genome Medicine, 2025, vol. 17

Fellowships & Awards

NWO Athena award for outstanding female researchers (2023)

ZonMw VICI (2021)

PhD Supervisor (co-promotor) of the year 2017, Graduate School of Life Sciences

Stimulerings Associate Professorship UMCU (2015)

ZonMw VIDI (2014)

ZonMw Veni (2010)

KNAW fellowship Ter Meulen Fund (2007)

 

 

External positions

Member International Scientific Advisory Board Welcome Trust Consortium Collaborative Award - On the site evaluations (2-yearly) and submitting evaluation reports - King's College London

lid wetenschappelijke adviesraad - advies ranking onderzoeksvoorstellen - Reuma Nederland

member international Scientific Advisory Board for our Wellcome Trust funded Collaborative Award - member international Scientific Advisory Board for our Wellcome Trust funded Collaborative Award - KCL London

Director focis center of excellence center (UMC Utrecht) - Internationaal netwerk clinical immunology societies - Federation of Clinical Immunology Societies (FOCIS)

Occasional consultant/speaker/advisor - gevraagd vanwege expertise - Takeda, Johnson&Johnson, Janssen, Sanofi, Regeneron, VC