Profile photo Esther van Kleef

Esther van Kleef

Assistant Professor

Biography

Esther van Kleef is a senior scientist at the University of Oxford, affiliated with the Oxford Nuffield Department of Medicine and holds an honorary appointment as assistant professor at the University Medical Centre Utrecht. She previously served as a technical consultant to the World Health Organization (WHO), where she spearheaded the analyses for the Global Surveillance of Antimicrobial Resistance Report 2025.

With expertise in quantitative methodology, mathematical modelling, and surveillance data analysis, Esther has worked in both high- and low-income settings. She has led interdisciplinary projects to enhance infectious disease surveillance and response in Europe and African settings.

Her current research explores key drivers and AMR transmission dynamics between community and healthcare settings and the effectiveness of mitigation strategies. Esther is particularly interested in the potential of sequencing data for AMR/ID surveillance and infection prevention & control, as well as exploring the role of the environment in AMR transmission, including the effective delivery of Water Access, Sanitation and Hygiene (WASH) strategies.

Esther earned a PhD in Infectious Disease Epidemiology from the London School of Hygiene & Tropical Medicine. She has held academic and public health roles at Mahidol Oxford Tropical Medicine Research Unit, Public Health England (UKHSA), the Dutch National Institute of Public Health and the Environment and the Institute of Tropical Medicine Antwerp. She has also been involved in WHO’s emergency outbreak response efforts, including leading epidemiological and data analysis teams during the 2019–2020 Ebola outbreak in the Democratic Republic of the Congo.

Recent publications

Global antibiotic resistance surveillance report 2025 Olga Tosas Auguet, Esther van Kleef, Anna Dean, Silvia Bertagnolio
2025
Modelling practices, data provisioning, sharing and dissemination needs for pandemic decision-making Esther van Kleef, Wim Van Bortel, Elena Arsevska, Luca Busani, Simon Dellicour, Laura Di Domenico, Marius Gilbert, Sabine L van Elsland, Moritz Ug Kraemer, Shengjie Lai, Philippe Lemey, Stefano Merler, Zoran Milosavljevic, Annapaola Rizzoli, Danijela Simic, Andrew J Tatem, Maguelonne Teisseire, William Wint, Vittoria Colizza, Chiara Poletto
Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin, 2025, vol. 30
Mapping global risk of bat and rodent borne disease outbreaks to anticipate emerging threats Soushieta Jagadesh, Claudia Cataldo, Wim Van Bortel, Esther Van Kleef, William Wint, Annapaola Rizzoli, Luca Busani, Elena Arsevska
Scientific Reports, 2025, vol. 15
Embedding risk monitoring in infectious disease surveillance for timely and effective outbreak prevention and control Brecht Ingelbeen, Esther van Kleef, Placide Mbala, Kostas Danis, Ivalda Macicame, Niel Hens, Eveline Cleynen, Marianne A B van der Sande
BMJ global health, 2025, vol. 10
Mild and moderate COVID-19 during Alpha, Delta and Omicron pandemic waves in urban Maputo, Mozambique, December 2020-March 2022 Brecht Ingelbeen, Victória Cumbane, Ferão Mandlate, Barbara Barbé, Sheila Mercedes Nhachungue, Nilzio Cavele, Cremildo Manhica, Catildo Cubai, Neusa Maimuna Carlos Nguenha, Audrey Lacroix, Joachim Mariën, Anja de Weggheleire, Esther van Kleef, Philippe Selhorst, Marianne A.B. van der Sande, Martine Peeters, Marc Alain Widdowson, Nalia Ismael, Ivalda Macicame
PLOS global public health, 2024, vol. 4
Importance of investing time and money in integrating large language model-based agents into outbreak analytics pipelines Albert Jan van Hoek, Sebastian Funk, Stefan Flasche, Billy J. Quilty, Esther van Kleef, Anton Camacho, Adam J. Kucharski
The Lancet Microbe, 2024, vol. 5