Profile photo Esther van Kleef

Esther van Kleef

Assistant Professor

Biography

Dr Esther van Kleef is a senior research associate working jointly between the Nuffield Department of Primary Care Health Sciences, and the Nuffield Department of Medicine, and holds a position as visiting Assistant Professor at University Medical Centre Utrecht. Before, she worked as a technical consultant to the World Health Organization (WHO), where she spearheaded the analyses for the Global Surveillance of Antimicrobial Resistance (AMR) Report 2025.

 

With expertise in quantitative epidemiology, infectious disease modelling, and surveillance data analysis, she leads interdisciplinary projects aimed at strengthening infectious disease surveillance and response across Europe and sub-Saharan Africa. Her current research focuses on using modelling approaches to understand and quantify the role of key AMR drivers, the transmission of AMR bacteria between community and healthcare settings, and the effectiveness of mitigation strategies. She has a particular interest in the use of sequencing data for infectious disease surveillance and infection prevention and control, as well as in understanding the role of environmental factors in the emergence and spread of AMR, including the effective implementation of water, sanitation, and hygiene (WASH) interventions, see e.g. EU-funded ALARUM and CABU-EICO.

 

Esther earned a PhD in Infectious Disease Epidemiology from the London School of Hygiene & Tropical Medicine. Before she was based at the Institute of Tropical Medicine Antwerp, and has held academic and public health roles at Mahidol Oxford Tropical Medicine Research Unit, Public Health England (UKHSA), and the Dutch National Institute of Public Health and the Environment. She has also been involved in WHO’s emergency outbreak response efforts, including leading epidemiological and data analysis teams during the 2019–2020 Ebola outbreak in the Democratic Republic of the Congo. 

Recent publications

Global antibiotic resistance surveillance report 2025 Olga Tosas Auguet, Esther van Kleef, Anna Dean, Silvia Bertagnolio
2025
Modelling practices, data provisioning, sharing and dissemination needs for pandemic decision-making Esther van Kleef, Wim Van Bortel, Elena Arsevska, Luca Busani, Simon Dellicour, Laura Di Domenico, Marius Gilbert, Sabine L van Elsland, Moritz Ug Kraemer, Shengjie Lai, Philippe Lemey, Stefano Merler, Zoran Milosavljevic, Annapaola Rizzoli, Danijela Simic, Andrew J Tatem, Maguelonne Teisseire, William Wint, Vittoria Colizza, Chiara Poletto
Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin, 2025, vol. 30
Mapping global risk of bat and rodent borne disease outbreaks to anticipate emerging threats Soushieta Jagadesh, Claudia Cataldo, Wim Van Bortel, Esther Van Kleef, William Wint, Annapaola Rizzoli, Luca Busani, Elena Arsevska
Scientific Reports, 2025, vol. 15
Embedding risk monitoring in infectious disease surveillance for timely and effective outbreak prevention and control Brecht Ingelbeen, Esther van Kleef, Placide Mbala, Kostas Danis, Ivalda Macicame, Niel Hens, Eveline Cleynen, Marianne A B van der Sande
BMJ global health, 2025, vol. 10
Mild and moderate COVID-19 during Alpha, Delta and Omicron pandemic waves in urban Maputo, Mozambique, December 2020-March 2022 Brecht Ingelbeen, Victória Cumbane, Ferão Mandlate, Barbara Barbé, Sheila Mercedes Nhachungue, Nilzio Cavele, Cremildo Manhica, Catildo Cubai, Neusa Maimuna Carlos Nguenha, Audrey Lacroix, Joachim Mariën, Anja de Weggheleire, Esther van Kleef, Philippe Selhorst, Marianne A.B. van der Sande, Martine Peeters, Marc Alain Widdowson, Nalia Ismael, Ivalda Macicame
PLOS global public health, 2024, vol. 4
Importance of investing time and money in integrating large language model-based agents into outbreak analytics pipelines Albert Jan van Hoek, Sebastian Funk, Stefan Flasche, Billy J. Quilty, Esther van Kleef, Anton Camacho, Adam J. Kucharski
The Lancet Microbe, 2024, vol. 5