Edwin Cuppen

Full Professor

Biography

Edwin Cuppen is initiator and scientific director of the Hartwig Medical Foundation (part-time since 2015 and full time since 2021), a not-for-profit organisation that aims to improve cancer care by systematic whole genome sequencing analysis of tumors and that also maintains one of the world’s largest databases of cancer whole genome sequencing data enriched with clinical patient data. After his undergraduate and PhD training at Wageningen University and Radboud University Nijmegen as a molecular geneticist, he held research and group leader positions at the Netherlands Cancer Institute, the Hubrecht Institute and the UMC Utrecht. His expertise is in cancer genomics and functional genetics.

Contact

ecuppen@umcutrecht.nl

Pure profile

Recent publications

All publications

Improved detection of colibactin-induced mutations by genotoxic E. coli in organoids and colorectal cancer Axel Rosendahl Huber, Cayetano Pleguezuelos-Manzano, Jens Puschhof, Joske Ubels, Charelle Boot, Aurelia Saftien, Mark Verheul, Laurianne T. Trabut, Niels Groenen, Markus van Roosmalen, Kyanna S. Ouyang, Henry Wood, Phil Quirke, Gerrit Meijer, Edwin Cuppen, Hans Clevers, Ruben van Boxtel
Cancer Cell, 2024, vol. 42, p.487-496.e6

Next generation sequencing of high-grade adult-type diffuse glioma in the Netherlands Mark P van Opijnen, Marike L D Broekman, Edwin Cuppen, Hendrikus J Dubbink, Arja Ter Elst, Ronald van Eijk, Angelika Mühlebner, Casper Jansen, Robert van der Geize, Ernst-Jan M Speel, Patricia J T A Groenen, Filip Y F de Vos, Pieter Wesseling, Wendy W J de Leng, Sybren L N Maas
Journal of Neuro-Oncology, 2024, vol. 166, p.485-492

EXO1 protects BRCA1-deficient cells against toxic DNA lesions Bert van de Kooij, Anne Schreuder, Raphael Pavani, Veronica Garzero, Sidrit Uruci, Tiemen J. Wendel, Arne van Hoeck, Marta San Martin Alonso, Marieke Everts, Dana Koerse, Elsa Callen, Jasper Boom, Hailiang Mei, Edwin Cuppen, Martijn S. Luijsterburg, Marcel A.T.M. van Vugt, André Nussenzweig, Haico van Attikum, Sylvie M. Noordermeer
Molecular Cell, 2024, vol. 84, p.659-674.e7

Multi-omic analysis identifies hypoalbuminemia as independent biomarker of poor outcome upon PD-1 blockade in metastatic melanoma Lindsay V M Leek, Jessica C L Notohardjo, Karlijn de Joode, Eline L Velker, John B A G Haanen, Karijn P M Suijkerbuijk, Maureen J B Aarts, Jan Willem B de Groot, Ellen Kapiteijn, Franchette W P J van den Berkmortel, Hans M Westgeest, Tanja D de Gruijl, Valesca P Retel, Edwin Cuppen, Astrid A M van der Veldt, Mariette Labots, Emile E Voest, Joris van de Haar, Alfons J M van den Eertwegh
Scientific Reports, 2024, vol. 14

A pan-cancer analysis of the microbiome in metastatic cancer Thomas W. Battaglia, Iris L. Mimpen, Joleen J.H. Traets, Arne van Hoeck, Laurien J. Zeverijn, Birgit S. Geurts, Gijs F. de Wit, Michaël Noë, Ingrid Hofland, Joris L. Vos, Sten Cornelissen, Maartje Alkemade, Annegien Broeks, Charlotte L. Zuur, Edwin Cuppen, Lodewyk Wessels, Joris van de Haar, Emile Voest
Cell, 2024, vol. 187, p.2324-2335.e19

The 1+Million Genomes Minimal Dataset for Cancer Michela Riba, Cinzia Sala, Aedin C. Culhane, Åsmund Flobak, Attila Patocs, Kjetil Boye, Karla Plevova, Šárka Pospíšilová, Giorgia Gandolfi, Marco J. Morelli, Gabriele Bucci, Anders Edsjö, Ulrik Lassen, Fátima Al-Shahrour, Nuria Lopez-Bigas, Randi Hovland, Edwin Cuppen, Alfonso Valencia, Helene A. Poirel, Richard Rosenquist, Serena Scollen, Juan Arenas Marquez, Jeroen Belien, Arcangela De Nicolo, Ruggero De Maria, David Torrents, Giovanni Tonon
Nature Genetics, 2024, vol. 56, p.733-736

External positions

Scientific Director, Hartwig Medical Foundation