Edwin Cuppen

Full Professor

Biography

Edwin Cuppen is initiator and scientific director of the Hartwig Medical Foundation (part-time since 2015 and full time since 2021), a not-for-profit organisation that aims to improve cancer care by systematic whole genome sequencing analysis of tumors and that also maintains one of the world’s largest databases of cancer whole genome sequencing data enriched with clinical patient data. After his undergraduate and PhD training at Wageningen University and Radboud University Nijmegen as a molecular geneticist, he held research and group leader positions at the Netherlands Cancer Institute, the Hubrecht Institute and the UMC Utrecht. His expertise is in cancer genomics and functional genetics.

Contact

ecuppen@umcutrecht.nl

Pure profile

Recent publications

All publications

Improved detection of colibactin-induced mutations by genotoxic E. coli in organoids and colorectal cancer Axel Rosendahl Huber, Cayetano Pleguezuelos-Manzano, Jens Puschhof, Joske Ubels, Charelle Boot, Aurelia Saftien, Mark Verheul, Laurianne T. Trabut, Niels Groenen, Markus van Roosmalen, Kyanna S. Ouyang, Henry Wood, Phil Quirke, Gerrit Meijer, Edwin Cuppen, Hans Clevers, Ruben van Boxtel
Cancer Cell, 2024, vol. 42, p.487-496.e6

Five latent factors underlie response to immunotherapy Joseph Usset, Axel Rosendahl Huber, Maria A. Andrianova, Eduard Batlle, Joan Carles, Edwin Cuppen, Elena Elez, Enriqueta Felip, Marina Gómez-Rey, Deborah Lo Giacco, Francisco Martinez-Jimenez, Eva Muñoz-Couselo, Lillian L. Siu, Josep Tabernero, Ana Vivancos, Ferran Muiños, Abel Gonzalez-Perez, Nuria Lopez-Bigas
Nature genetics, 2024, vol. 56, p.2112-2120

Next generation sequencing of high-grade adult-type diffuse glioma in the Netherlands Mark P van Opijnen, Marike L D Broekman, Edwin Cuppen, Hendrikus J Dubbink, Arja Ter Elst, Ronald van Eijk, Angelika Mühlebner, Casper Jansen, Robert van der Geize, Ernst-Jan M Speel, Patricia J T A Groenen, Filip Y F de Vos, Pieter Wesseling, Wendy W J de Leng, Sybren L N Maas
Journal of Neuro-Oncology, 2024, vol. 166, p.485-492

EXO1 protects BRCA1-deficient cells against toxic DNA lesions Bert van de Kooij, Anne Schreuder, Raphael Pavani, Veronica Garzero, Sidrit Uruci, Tiemen J. Wendel, Arne van Hoeck, Marta San Martin Alonso, Marieke Everts, Dana Koerse, Elsa Callen, Jasper Boom, Hailiang Mei, Edwin Cuppen, Martijn S. Luijsterburg, Marcel A.T.M. van Vugt, André Nussenzweig, Haico van Attikum, Sylvie M. Noordermeer
Molecular Cell, 2024, vol. 84, p.659-674.e7

The role of molecular biomarkers in recurrent glioblastoma trials Mark P van Opijnen, Filip Y F de Vos, Edwin Cuppen, Marjolein Geurts, Sybren L N Maas, Marike L D Broekman
Medical Oncology, 2024, vol. 41

Multi-omic analysis identifies hypoalbuminemia as independent biomarker of poor outcome upon PD-1 blockade in metastatic melanoma Lindsay V M Leek, Jessica C L Notohardjo, Karlijn de Joode, Eline L Velker, John B A G Haanen, Karijn P M Suijkerbuijk, Maureen J B Aarts, Jan Willem B de Groot, Ellen Kapiteijn, Franchette W P J van den Berkmortel, Hans M Westgeest, Tanja D de Gruijl, Valesca P Retel, Edwin Cuppen, Astrid A M van der Veldt, Mariette Labots, Emile E Voest, Joris van de Haar, Alfons J M van den Eertwegh
Scientific Reports, 2024, vol. 14

Fellowships & Awards

European Young Investigator Award 2005

NWO Vici grant 2013

External positions

Committee member - Selection Board Committee for a Group Leader & Professor position in cancer systems biomedicine - Institute of Cancer Research (ICR), Oslo University Hospit

Spreker - Houden van lezingen - Spreker bij diverse organisaties

Advies - Researchgebied - Advisory Board Clinical Whole Genome Sequencing Illumina

Scientific Director - overeenkomstig researchgebied - Hartwig Medical Foundation

Advisering - Raakvlakken met onderzoeksveld - Scientific Advisory Board InteRNA Technologies BV (miRNA-b