Edwin Cuppen

Full Professor

Biography

Edwin Cuppen is initiator and scientific director of the Hartwig Medical Foundation (part-time since 2015 and full time since 2021), a not-for-profit organisation that aims to improve cancer care by systematic whole genome sequencing analysis of tumors and that also maintains one of the world’s largest databases of cancer whole genome sequencing data enriched with clinical patient data. After his undergraduate and PhD training at Wageningen University and Radboud University Nijmegen as a molecular geneticist, he held research and group leader positions at the Netherlands Cancer Institute, the Hubrecht Institute and the UMC Utrecht. His expertise is in cancer genomics and functional genetics.

Contact

ecuppen@umcutrecht.nl

Pure profile

Recent publications

All publications

Whole genome sequencing of 378 prostate cancer metastases reveals tissue selectivity for mismatch deficiency with potential therapeutic implications Daniel J Vis, Sander A L Palit, Marie Corradi, Edwin Cuppen, Niven Mehra, Martijn P Lolkema, Lodewyk F A Wessels, Michiel S van der Heijden, Wilbert Zwart, Andries M Bergman
Genome Medicine, 2025, vol. 17

The role of molecular biomarkers in recurrent glioblastoma trials Mark P van Opijnen, Filip Y F de Vos, Edwin Cuppen, Marjolein Geurts, Sybren L N Maas, Marike L D Broekman
Medical Oncology, 2024, vol. 41

Five latent factors underlie response to immunotherapy Joseph Usset, Axel Rosendahl Huber, Maria A. Andrianova, Eduard Batlle, Joan Carles, Edwin Cuppen, Elena Elez, Enriqueta Felip, Marina Gómez-Rey, Deborah Lo Giacco, Francisco Martinez-Jimenez, Eva Muñoz-Couselo, Lillian L. Siu, Josep Tabernero, Ana Vivancos, Ferran Muiños, Abel Gonzalez-Perez, Nuria Lopez-Bigas
Nature genetics, 2024, vol. 56, p.2112-2120

A pan-cancer analysis of the microbiome in metastatic cancer Thomas W. Battaglia, Iris L. Mimpen, Joleen J.H. Traets, Arne van Hoeck, Laurien J. Zeverijn, Birgit S. Geurts, Gijs F. de Wit, Michaël Noë, Ingrid Hofland, Joris L. Vos, Sten Cornelissen, Maartje Alkemade, Annegien Broeks, Charlotte L. Zuur, Edwin Cuppen, Lodewyk Wessels, Joris van de Haar, Emile Voest
Cell, 2024, vol. 187, p.2324-2335.e19

Combining Genomic Biomarkers to Guide Immunotherapy in Non-Small Cell Lung Cancer Joris Van De Haar, Joanne M. Mankor, Karlijn Hummelink, Kim Monkhorst, Egbert F. Smit, Lodewyk F.A. Wessels, Edwin Cuppen, Joachim G.J.V. Aerts, Emile E. Voest
Clinical Cancer Research, 2024, vol. 30, p.1307-1318

EXO1 protects BRCA1-deficient cells against toxic DNA lesions Bert van de Kooij, Anne Schreuder, Raphael Pavani, Veronica Garzero, Sidrit Uruci, Tiemen J. Wendel, Arne van Hoeck, Marta San Martin Alonso, Marieke Everts, Dana Koerse, Elsa Callen, Jasper Boom, Hailiang Mei, Edwin Cuppen, Martijn S. Luijsterburg, Marcel A.T.M. van Vugt, André Nussenzweig, Haico van Attikum, Sylvie M. Noordermeer
Molecular Cell, 2024, vol. 84, p.659-674.e7

Fellowships & Awards

European Young Investigator Award 2005

NWO Vici grant 2013

External positions

Spreker - Houden van lezingen - Spreker bij diverse organisaties

Advies - Researchgebied - Advisory Board Clinical Whole Genome Sequencing Illumina

Scientific Director - overeenkomstig researchgebied - Hartwig Medical Foundation

Advisering - Raakvlakken met onderzoeksveld - Scientific Advisory Board InteRNA Technologies BV (miRNA-b