Profile photo Edward Nieuwenhuis

Edward Nieuwenhuis

Full Professor

Strategic program(s):

Biography

Edward Nieuwenhuis, pediatrician, obtained a PhD in mucosal immunology (Prof. Blumberg, Harvard University and Prof. Heijnen, Utrecht University). He became a paediatric gastroenterologist, focusing     on the innate immunesystem in Inflammatory Bowel Disease. His work includes the development of a enterocolitis model in Zebrafish. His current research focuses on IBD, somatic stemcells, epithelial biology and genetics.

In 2009, Edward Nieuwenhuis was appointed as Chairman of the Paediatrics Division of the Wilhelmina Children’s Hospital Utrecht , The Netherlands. In 2010, he was also appointed as Chairman of the    leading program (speerpunt) Child Health of  the University Medical Center Utrecht.

During this period, the Hospital has established strong alliances with medical centers and research institutes in the Netherlands (e.g. Maxima, national center for pediatric oncology, Hubrecht institute for developmental biology & stem cell research) and abroad (e.g. Boston Children’s, The Hospital for Sick Children, Toronto, Hospital Pablo Tobon Uribe, Medellin).

His goal is to build an integrated academic Children’s Hospital which provides health care, medical training and science of excellent standards.

Recent publications

A Collection of Patient-Derived Intestinal Organoid Lines Reveals Epithelial Phenotypes Associated with Genetic Drivers of Pediatric Inflammatory Bowel Disease Zahra Shojaei Jeshvaghani, Carmen Argmann, Maaike H de Vries, Johan H van Es, Lauren V Collen, Daniel Kotlarz, Mia Sveen, Phillip H Comella, Scott B Snapper, Christoph Klein, Eric E Schadt, Hans Clevers, Michal Mokry, Ewart Kuijk, Edward Nieuwenhuis
Inflammatory bowel diseases, 2025, vol. 32, p.9-24
Human colon stem cells are the predominant epithelial responders to bacterial antigens Maaike H De Vries, Claartje A Meddens, Hemme J Hijma, Anne-Claire Berrens, Suze A Jansen, Berend A P Kooiman, Scott Snapper, Hans Clevers, Michal Mokry, Ewart W Kuijk, Edward E S Nieuwenhuis
Frontiers in Immunology, 2025, vol. 16
A collection of patient-derived intestinal organoid lines reveals epithelial pheno-types associated with genetic drivers of pediatric inflammatory bowel disease Zahra Shojaei Jeshvaghani, Carmen Argmann, Michal Mokry, Johan H van Es, Maaike H de Vries, Lauren V Collen, Daniel Kotlarz, Mia Sveen, Phillip Comella, Scott B Snapper, Christoph Klein, Eric Schadt, Hans Clevers, Ewart Kuijk, Edward Nieuwenhuis
2025
Correction of pathogenic mitochondrial DNA in patient-derived disease models using mitochondrial base editors Indi P Joore, Sawsan Shehata, Irena Muffels, Jose Castro-Alpízar, Elena Jiménez-Curiel, Emilia Nagyova, Natacha Levy, Ziqin Tang, Kimberly Smit, Wilbert P Vermeij, Richard Rodenburg, Raymond Schiffelers, Edward E S Nieuwenhuis, Peter M van Hasselt, Sabine A Fuchs, Martijn A J Koppens
PLoS Biology, 2025, vol. 23
Innate immunity of the gut epithelium Maaike H de Vries, Ewart W Kuijk, Edward E S Nieuwenhuis
Mucosal immunology, 2025, vol. 18, p.1005-1012
Therapeutic Application of mRNA for Genetic Diseases Paul J.L. Schürmann, Stijn P.E. van Breda Vriesman, Jose A. Castro-Alpízar, Sander A.A. Kooijmans, Edward E.S. Nieuwenhuis, Raymond M. Schiffelers, Sabine A. Fuchs
Wiley Interdisciplinary Reviews: Nanomedicine and Nanobiotechnology, 2025, vol. 17

External positions

Raad van Toezicht - gezondheidszorg - Zorgsaam Terneuzen