Profile photo Edward Nieuwenhuis

Edward Nieuwenhuis

Full Professor

Strategic program(s):

Biography

Edward Nieuwenhuis, pediatrician, obtained a PhD in mucosal immunology (Prof. Blumberg, Harvard University and Prof. Heijnen, Utrecht University). He became a paediatric gastroenterologist, focusing     on the innate immunesystem in Inflammatory Bowel Disease. His work includes the development of a enterocolitis model in Zebrafish. His current research focuses on IBD, somatic stemcells, epithelial biology and genetics.

In 2009, Edward Nieuwenhuis was appointed as Chairman of the Paediatrics Division of the Wilhelmina Children’s Hospital Utrecht , The Netherlands. In 2010, he was also appointed as Chairman of the    leading program (speerpunt) Child Health of  the University Medical Center Utrecht.

During this period, the Hospital has established strong alliances with medical centers and research institutes in the Netherlands (e.g. Maxima, national center for pediatric oncology, Hubrecht institute for developmental biology & stem cell research) and abroad (e.g. Boston Children’s, The Hospital for Sick Children, Toronto, Hospital Pablo Tobon Uribe, Medellin).

His goal is to build an integrated academic Children’s Hospital which provides health care, medical training and science of excellent standards.

Recent publications

Human colon stem cells are the principal epithelial responders to bacterial antigens Maaike Hillegonda de Vries, Claartje Meddens, Hemme Hijma, Anne-Claire Berrens, Suze Jansen, Berend Kooiman, Scott Snapper, Hans Clevers, Michal Mokry, Ewart Kuijk, Edward Nieuwenhuis
2025
Imaging flow cytometry-based cellular screening elucidates pathophysiology in individuals with Variants of Uncertain Significance Irena Josephina Johanna Muffels, Hans R. Waterham, Giuseppina D’Alessandro, Guido Zagnoli-Vieira, Michael Sacher, Dirk J. Lefeber, Celine Van der Vinne, Chaim M. Roifman, Koen L.I. Gassen, Holger Rehmann, Desiree Y. Van Haaften-Visser, Edward S.S. Nieuwenhuis, Stephen P. Jackson, Sabine A. Fuchs, Femke Wijk, Peter van Hasselt
Genome Medicine, 2025, vol. 17
TTC7A missense variants in intestinal disease can be classified by molecular and cellular phenotypes Zahra Shojaei Jeshvaghani, Marjolein Mijnders, Irena Muffels, Sander van Beekhuizen, Daniel Kotlarz, Caroline A Lindemans, Sibylle Koletzko, Christoph Klein, Michal Mokry, Edward Nieuwenhuis, Ewart Kuijk
Human molecular genetics, 2024, vol. 34, p.313-326
Isoleucine-to-valine substitutions support cellular physiology during isoleucine deprivation Gautam Kok, Imre F Schene, Eveline F Ilcken, Paula Sobrevals Alcaraz, Marisa I Mendes, Desiree E C Smith, Gajja Salomons, Sawsan Shehata, Judith J M Jans, Reza Maroofian, Tim A Hoek, Robert M van Es, Holger Rehmann, Edward E S Nieuwenhuis, Harmjan R Vos, Sabine A Fuchs
Nucleic acids research, 2024, vol. 53
Enrichment of cell cycle pathways in progesterone-treated endometrial organoids of infertile women compared to fertile women B N Bui, A I Ardisasmita, F H van de Vliert, M S Abendroth, M van Hoesel, S Mackens, S A Fuchs, E E S Nieuwenhuis, F J M Broekmans, G S Steba
Journal of Assisted Reproduction and Genetics, 2024, vol. 41, p.2405-2418
Position Paper Rinske IJsselhof, Amy Hintjens, Anne Pelzer, Edward Nieuwenhuis
European child & adolescent psychiatry, 2024, vol. 33, p.3287-3292

External positions

Raad van Toezicht - gezondheidszorg - Zorgsaam Terneuzen