Eric Spierings

Associate Professor

Strategic program(s):

Biography

Dr. Spierings received his PhD degree as immunologist at the Leiden University Medical Center, The Netherlands and was subsequently recognized as SMBWO Immunologist by the Dutch Society for Immunology. His postdoctoral training was performed on minor H antigens in organ- and stem-cell transplantation in the laboratory of Prof. Dr. Els Goulmy, Leiden, The Netherlands. In 2008, he was appointed as lab director of the HLA laboratory of the University Medical Centre Utrecht, The Netherlands. In that position, he combines diagnostic histocompatibility testing with research. His current scientific interest focusses on the role of indirect recognition of mismatched HLA in transplantation and on post-transplant immunomonitoring via Next Generation Sequencing of T- and B-cell receptors and immunoglobulins.

Strategic program(s):

Contact

espierin@umcutrecht.nl

Pure profile

Research groups

Transplantation

Research aim

We aim to understand how infection and immunity impact transplantation. By uncovering these mechanisms, we aim to improve patient care, reduce rejection and complications, and enhance success rates, benefiting society with better health outcomes.

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Recent publications

All publications

Determination of the clinical relevance of donor epitope-specific HLA-antibodies in kidney transplantation Tineke Kardol-Hoefnagel, Danial Mohammadi Senejohnny, Elena G Kamburova, Bram W Wisse, Leon Reteig, Maartje L Gruijters, Irma Joosten, Wil A Allebes, Arnold van der Meer, Luuk B Hilbrands, Marije C Baas, Eric Spierings, Cornelis E Hack, Franka E van Reekum, Arjan D van Zuilen, Marianne C Verhaar, Michiel L Bots, Adriaan C A D Drop, Loes Plaisier, Rowena C A Melchers, Marc A J Seelen, Jan Stephan Sanders, Bouke G Hepkema, Annechien J A Lambeck, Laura B Bungener, Caroline Roozendaal, Marcel G J Tilanus, Christina E Voorter, Lotte Wieten, Elly M van Duijnhoven, Mariëlle A C J Gelens, Maarten H L Christiaans, Frans J van Ittersum, Shaikh A Nurmohamed, Neubury M Lardy, Wendy Swelsen, Karlijn A M I van der Pant, Neelke C van der Weerd, Ineke J M Ten Berge, Andries Hoitsma, Paul J M van der Boog, Johan W de Fijter, Michiel G H Betjes, Dave L Roelen, Frans H Claas, Frederike J Bemelman, Aleksandar Senev, Maarten Naesens, Sebastiaan Heidt, Henny G Otten
HLA, 2024, vol. 103

Histocompatibility Eric Spierings, Alejandro Madrigal, Katharina Fleischhauer
2024, p.73-84

Quantifying uncertainty of molecular mismatch introduced by mislabeled ancestry using haplotype-based HLA genotype imputation Benedict M Matern, Eric Spierings, Selle Bandstra, Abeer Madbouly, Stefan Schaub, Eric T Weimer, Matthias Niemann
Frontiers in Genetics, 2024, vol. 15

Paternal HLA-Derived Epitopes and Live Birth in Secondary Recurrent Pregnancy Loss Maria Christine Krog, Emma T.M. Peereboom, Kirsten Geneugelijk, Benedict M. Matern, Astrid Marie Kolte, Ole Bjarne Christiansen, Rudi Steffensen, Henriette Svarre Nielsen, Eric Spierings
HLA, 2024, vol. 104

Ellipro scores of donor epitope specific HLA antibodies are not associated with kidney graft survival Tineke Kardol-Hoefnagel, Danial Mohammadi Senejohnny, Elena G. Kamburova, Bram W. Wisse, Maartje L. Gruijters, Irma Joosten, Wil A. Allebes, Arnold van der Meer, Luuk B. Hilbrands, Marije C. Baas, Eric Spierings, Cornelis E. Hack, Franka E. van Reekum, Arjan D. van Zuilen, Marianne C. Verhaar, Adriaan C.A.D. Drop, Loes Plaisier, Rowena C.A. Melchers, Marc A.J. Seelen, Jan Stephan Sanders, Bouke G. Hepkema, Bart Jan Kroesen, Laura B. Bungener, Caroline Roozendaal, Marcel G.J. Tilanus, Christina E. Voorter, Lotte Wieten, Elly M. van Duijnhoven, Mariëlle A.C.J. Gelens, Maarten H.L. Christiaans, Frans J. van Ittersum, Shaikh A. Nurmohamed, Neubury M. Lardy, Wendy Swelsen, Karlijn A.M.I. van der Pant, Neelke C. van der Weerd, Ineke J.M. ten Berge, Andries Hoitsma, Paul J.M. van der Boog, Johan W. de Fijter, Michiel G.H. Betjes, Dave L. Roelen, Frans H. Claas, Frederike J. Bemelman, Sebastiaan Heidt, Henny G. Otten
HLA, 2024, vol. 103

PIRCHE-II Risk and Acceptable Mismatch Profile Analysis in Solid Organ Transplantation Matthias Niemann, Benedict M Matern, Eric Spierings
Methods in molecular biology (Clifton, N.J.), 2024, vol. 2809, p.171-192

Fellowships & Awards

1997: KNAW van Walree Grant
2002: Best Abstract Award – 13th International Histocompatibility Workshop Conference
2004: Special Fellow – Leukemia and Lymphoma Society
2007: Best Abstract Award – European Federation for Immunogenetics Conference
2009: Best Abstract Award – European Federation for Immunogenetics Conference
2013: Ureka Mega Challenge Award for Innovation – UMC Utrecht
2016: Novartis Award for best scientific publication – Dutch Transplantation Society
2017: Medical Immunology Science Award – Dutch Society for Immunology

External positions

Member of the Scientific Committee - Member of the Scientific Committee - European Federation for Immunogenetics

Co-president - HLA, transplantation, and immunogenetics - International HLA & Immunogenetics Workshop Council

Contract Research - Onderzoek naar T cel en B cel epitopen en verfijnen van bestaande algoritmes - PIRCHE AG

Medisch Immunoloog Kenniscentrum MATCHIS. Consultverlening in het kader van stamceltransplantatie. - Histocompatibiliteit in stamceltransplantatie. Complementair en niet competerend. - Stichting MATCHIS

Member of the Editorial Board - Member of the Editorial Board - HLA Immune Response Genetics

Chair of the IT and Bioinformatics Committee - HLA and automation - European Federation for Immunogenetics

Chair of the Bioinformatics and IT Committee - Chair of the Bioinformatics and IT Committee - European Federation for Immunogenetics

Chair and Treasurer - HLA, transplantation, and Immunogenetics - 18th International HLA&Immunogenetics Workshop Foundation

Associate Editor - Associate Editor - Frontiers in Immunology

Member of the Editorial Board - Member of the Editorial Board - Cellular Immunology

Contract Research and advisory function - HLA matching at the epitope level - PIRCHE AG