Dylan de Lange

Full Professor

Strategic program(s):

Biography

Dylan de Lange started his medical education at the University of Utrecht in 1992. After graduating he started as a resident in Internal Medicine in a teaching hospital in Amersfoort but he finished his residency in the University Medical Center in Utrecht (UMC Utrecht). Afterwards he did a fellowship in Infectious Diseases and subsequently a fellowship in Intensive Care Medicine. In 2007 he joined the medical staff of the Intensive Care Unit and the Dutch Poisons Information Center (DPIC) in the University Medical Center Utrecht, where he has been working ever since.

Since 2017 he is full professor in Clinical Toxicology and the chair of the Dutch Poisons Information Center (nvic.umcutrecht.nl). As a clinical toxicologist (European Registered Toxicologist, ERT) he advises on medical treatment of intoxicated patients. The Dutch Poisons Information Center is contacted for medical advice over 240,000 times per year by other medical professionals.

He is a board member of the National Intensive Care Evaluation (NICE) Foundation, which benchmarks the all Dutch ICUs. Part of his current research is derived from this large national registry: (long term) outcome after intensive care treatment. Not only mortality is important but also the health related quality of life (HRQoL). Can we predict good/bad outcome?

His research interests obviously situate at the intersection of Clinical Toxicology and Intensive Care Medicine and focusses on "predicting outcome" in:

critically ill intoxicated patient
critically ill patients, especially in regard to the pharmacokinetics and toxicokinetics of antimicrobials and immunosuppressants
critically ill patients with the use of biomarkers

In 2019 a large European research project started looking at the (long-term) outcomes of intoxicated patients on various ICUs in the World. Can we predict outcome based on variables that ate present at admission to the hospital? This INTOXICATE study is now closed and the first analyses are being published.

Strategic program(s):

Contact

dlange3@umcutrecht.nl

Pure profile

Recent publications

All publications

Acute cardiovasculaire klachten na drugsgebruik Femke M.J. Gresnigt, Eric J.F. Franssen, Dylan de Lange, Robert Riezebos
Nederlands Tijdschrift voor Geneeskunde, 2025, vol. 169

Behandeling bij paracetamolintoxicatie kan korter Arjen Koppen, Douwe Dekker, Dylan W. de Lange, Harmen E. Postema, Hjalmar R. Bouma, Marieke G.G. Sturkenboom
Nederlands Tijdschrift voor Geneeskunde, 2025, vol. 169

Can the intensive care requirement score improve triage at the emergency department for acutely intoxicated patients? Samanta M. Zwaag, Dylan W. de Lange, Sylvia S. Brinkman, Irma S. van den Hengel-Koot, Claudine C. Hunault
Clinical Toxicology , 2025, vol. 63, p.849-859

Development and Validation of the Sequential Organ Failure Assessment (SOFA)-2 Score Otavio T Ranzani, Mervyn Singer, Jorge I F Salluh, Manu Shankar-Hari, David Pilcher, Joana Berger-Estilita, Craig M Coopersmith, Nicole P Juffermans, John Laffey, Matti Reinikainen, Ary Serpa Neto, Miguel Tavares, Jean-François Timsit, Maria Del Pilar Arias Lopez, Nish Arulkumaran, Diptesh Aryal, Elie Azoulay, Leo Anthony Celi, Dipayan Chaudhuri, Dylan De Lange, Jan De Waele, Claudia C Dos Santos, Bin Du, Sharon Einav, Teresa Engelbrecht, Fathima Fazla, Ricard Ferrer, Stefano Finazzi, Tomoko Fujii, Hayley B Gershengorn, John D Greene, Rashan Haniffa, Sicheng Hao, Mohd Shahnaz Hasan, Steve Hollenberg, Mariachiara Ippolito, Christian Jung, Mikhail Kirov, Shigetaka Kobari, Inès Lakbar, Jeffrey Lipman, Vincent Liu, Xiaoli Liu, Suzana M Lobo, Demetrio Magatti, Greg S Martin, Barbara Metnitz, Philipp Metnitz, Sheila N Myatra, Simon Oczkowski, José-Artur Paiva, Fathima Paruk, Pirkka T Pekkarinen, Lise Piquilloud, Anssi Pölkki, Hallie C Prescott, Annika Reintam Blaser, Ederlon Rezende, Chiara Robba, Bram Rochwerg, Stephane Ruckly, Rasoul Samei, Edward J Schenck, Paul Secombe, Cornelius Sendagire, Moses Siaw-Frimpong, Andrew J Simpkin, Márcio Soares, Charlotte Summers, Wojciech Szczeklik, Jukka Takala, Shiro Tanaka, Giovanni Tricella, Jean-Louis Vincent, Julia Wendon, Fernando G Zampieri, Andrew Rhodes, Rui Moreno
JAMA, 2025, vol. 334, p.2090-2103

Rationale and Methodological Approach Underlying the Development of the Sequential Organ Failure Assessment (SOFA)-2 Score Rui Moreno, Andrew Rhodes, Otavio Ranzani, Jorge I.F. Salluh, Joana Berger-Estilita, Craig M. Coopersmith, Nicole P. Juffermans, John Laffey, Matti Reinikainen, Ary Serpa Neto, Miguel Tavares, Jean François Timsit, Maria Del Pilar Arias Lopez, Nish Arulkumaran, Elie Azoulay, Dipayan Chaudhuri, Dylan De Lange, Jan De Waele, Claudia C. Dos Santos, Bin Du, Sharon Einav, Ricard Ferrer, Tomoko Fujii, Hayley B. Gershengorn, Rashan Haniffa, Mohd Shahnaz Hasan, Steve Hollenberg, Mariachiara Ippolito, Christian Jung, Mikhail Kirov, Inès Lakbar, Jeffrey Lipman, Vincent Liu, Suzana Margareth Lobo, Greg S. Martin, Philipp Metnitz, Sheila N. Myatra, Simon Oczkowski, José Artur Paiva, Fathima Paruk, Pirkka T. Pekkarinen, David Pilcher, Lise Piquilloud, Anssi Pölkki, Halle C. Prescott, Annika Reintam Blaser, Ederlon Rezende, Chiara Robba, Bram Rochwerg, Edward J. Schenck, Cornelius Sendagire, Moses Siaw-Frimpong, Andrew J. Simpkin, Márcio Soares, Charlotte Summers, Wojciech Szczeklik, Jukka Takala, Jean Louis Vincent, Julia Wendon, Fernando G. Zampieri, Manu Shankar-Hari, Mervyn Singer
JAMA network open, 2025, vol. 8

Understanding barriers and facilitators to implementation of consensus-based recommendations for the management of very old people in intensive care Richard S. Bourne, Laura Alberto, Nathan E. Brummel, Bas De Groot, Dylan W. De Lange, Paul Elbers, Marielle H. Emmelot-Vonk, Hans Flaatten, Yonathan Freund, Alessandro Galazzi, Ana Garcia-Martinez, Bertrand Guidet, Iva Holmerová, Jeremy M. Jacobs, Gavin M. Joynt, Susannah Leaver, Marc Leone, Bairbre McNicholas, David McWilliams, Victoria Metaxa, Christian H. Nickel, Daniele Poole, Chiara Robba, Kevin Roedl, Marc Romain, Anne Françoise Rousseau, Sviri Sigal, Wojciech Szczeklik, Hélène Vallet, James Van Oppen, Christian Jung, Michael Beil
Age and ageing, 2025, vol. 54

External positions

Senior editor van editorial board wetenschappelijk tijdschrift "Clinical Toxicology" - beoordelen van manuscripten voor publicatie in het tijdschrift - Taylor & Francis (editor of Clin Tox)

raad van Toezicht van de Postdoctorale Educatie in Toxicologie (PET) - Controle van de inhoud en kwaliteit van het onderwijs in toxicologie - Nederlandse Vereniging voor Toxicologie (NVT)

Lid van Special Interest Group (SIG) van de European Association of Hospital Pharmacists (EAHP) - medicatieveligheid op de ICU - European Society Intensive Care Medicine (ESICM)

Lid van het expertiseteam behandeling COVID-19 - - Federatie Medisch Specialisten (FMS)

lid van de werkgroep voor de medicamenteuze behandeling van COVID-19 - - Stichting Werkgroep Antibioticabeleid (SWAB)

Organisatie en docent van de multidisciplinaire cursus toxicoogie - docent toxicologie - Schola Medica

Congrescommissie van de NVIC - organiseren van IC congressen past bij nascholing voor collega's - Nederlandse Vereniging Intensive Care (NVIC)

Overleg niet-geregistreerde geneesmiddelen en antidota voor de calamiteitenvoorraad - Indicatiestelling en voorraad advies van antisera en antidota - RIVM

lid van de Taskforce Infectieuze Bedreigingen van de NVIC (sinds 2009) - infecties op de IC - NVIC

secretaris Stichting NICE (lid sinds 2007) - Kwaliteitsregistratie van de Nederlandse Intensive Cares - Stichting Nationale Intensive Care Evaluatie (NICE)