Dominique de Kleijn

Full Professor

Strategic program(s):

Contact

dkleijn@umcutrecht.nl

Pure profile

Research groups

Therapy of atherosclerosis and aneurysms

Research aim

Development and validation of image guided interventions, medical devices and pharmaceutical interventions (eg anti-inflammatory/coagulation) to improve outcome of atherosclerotic disease and aneurysms

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Recent publications

All publications

Genetically determined ancestry associates with morphological and molecular carotid plaque features Nima Fahim, Tim R Sakkers, Joost Hoekstra, Dominique P V de Kleijn, Michal Mokry, Jose Verdezoto Mosquera, Gerard Pasterkamp, Hester M den Ruijter, Clint L Miller, Jessica van Setten, Sander W van der Laan
2025

Proteomic profiling reveals a higher presence of glycolytic enzymes in human atherosclerotic lesions with unfavourable histological characteristics Kaylin C A Palm, Xiaoke Yin, Ferheen Baig, Konstantinos Theofilatos, Sander W van der Laan, Gert J de Borst, Dominique P V de Kleijn, Johann Wojta, Stefan Stojkovic, Manuel Mayr, Hester M den Ruijter, Gerard Pasterkamp, Ernest Diez Benavente, Michal Mokry
Cardiovascular research, 2025, vol. 121, p.1187-1203

Interleukin-6 modifies Lipoprotein(a) and oxidized phospholipids associated cardiovascular disease risk in a secondary prevention cohort Niekbachsh Mohammadnia, Amber van Broekhoven, Willem A Bax, John W Eikelboom, Arend Mosterd, Aernoud T L Fiolet, Jan G P Tijssen, Peter L Thompson, Dominique P V de Kleijn, Sotirios Tsimikas, Jan H Cornel, Calvin Yeang, Saloua El Messaoudi
Atherosclerosis, 2025, vol. 405

Endothelial-to-mesenchymal transition gene signature derived from single-cell transcriptomics of human atherosclerotic tissue associates with stable plaque histological characteristics Lotte Slenders, Marian Wesseling, Siting Wei, Arjan Boltjes, Daniek M C Kapteijn, Petra van de Kraak, Marie A C Depuydt, Koen Prange, Noortje A M van den Dungen, Ernest Diez Benavente, Dominique P V de Kleijn, Gert J de Borst, Menno de Winther, Hester M den Ruijter, Gary K Owens, Gerard Pasterkamp, Michal Mokry
Vascular Pharmacology, 2025, vol. 159

Female-biased vascular smooth muscle cell gene regulatory networks predict MYH9 as a key regulator of fibrous plaque phenotype R Noah Perry, Graham Lenert, Ernest Diez Benavente, Angela Ma, Nicolas Barbera, Michal Mokry, Dominique P V de Kleijn, Menno P J de Winther, Manuel Mayr, Johan L M Björkegren, Hester M den Ruijter, Mete Civelek
2025

Intraplaque haemorrhage quantification and molecular characterisation using attention based multiple instance learning Francesco Cisternino, Yipei Song, Tim S Peters, Roderick Westerman, Gert J de Borst, Ernest Diez Benavente, Noortje A M van den Dungen, Petra H van der Kraak, Dominique De Kleijn, Joost M Mekke, Michal Mokry, Gerard Pasterkamp, Hester M den Ruijter, Evelyn Velema, Clint L Miller, Craig A Glastonbury, Sander W van der Laan
2025