Researchers Dennis Beringer

Dennis Beringer

Assistant Professor

Strategic program(s):

Biography

Dr Dennis Beringer is an assistant professor in the Center for Translational Immunology (CTI) at the University Medical Center Utrecht, the Netherlands. He obtained his PhD at Utrecht University in the field of structural biology. After which he moved to Monash University, Australia, where he investigated the molecular details of T cell receptor (TCR) – antigen interactions in autoimmune diseases and cancer. Intrigued by TCR biology, he returned to Utrecht to join the group of Jürgen Kuball at the UMCU in 2016 to study the molecular determinants of tumor reactive γδTCRs, for which he received a Marie Curie Individual Fellowship. Currently, he and his team are focusing on the optimization of existing and the development of novel γδ-TCR based therapeutics for cancer therapy, with a special emphasis on a new class of bispecific T cell engagers called GABs.

Strategic program(s):

Contact

dberinge@umcutrecht.nl

Pure profile

Research groups

Tumor Immunology

Research aim

Our research aims to revolutionise cancer treatment by advancing innovative immunotherapies, ensuring safer, more effective therapies, and improving patient outcomes, ultimately transforming lives through cutting-edge translational cancer research.

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Recent publications

All publications

Strategies to improve γδTCRs engineered T-cell therapies for the treatment of solid malignancies A D Meringa, P Hernández-López, A Cleven, M de Witte, T Straetemans, J Kuball, D X Beringer, Z Sebestyen
Frontiers in Immunology, 2023, vol. 14, p.1-7

Dual targeting of cancer metabolome and stress antigens affects transcriptomic heterogeneity and efficacy of engineered T cells Patricia Hernández-López, Eline van Diest, Peter Brazda, Sabine Heijhuurs, Angelo Meringa, Lauren Hoorens van Heyningen, Caterina Riillo, Caroline Schwenzel, Marina Zintchenko, Inez Johanna, Mara J T Nicolasen, Astrid Cleven, Thomas A Kluiver, Rosemary Millen, Jiali Zheng, Froso Karaiskaki, Trudy Straetemans, Hans Clevers, Remco de Bree, Hendrik G Stunnenberg, Weng Chuan Peng, Jeanine Roodhart, Susana Minguet, Zsolt Sebestyén, Dennis X Beringer, Jürgen Kuball
Nature immunology, 2023, vol. 25, p.88-101

The making of multivalent gamma delta TCR anti-CD3 bispecific T cell engagers Eline van Diest, Mara J T Nicolasen, Lovro Kramer, Jiali Zheng, Patricia Hernández-López, Dennis X Beringer, Jürgen Kuball
Frontiers in Immunology, 2023, vol. 13

γ9δ2 T-Cell Expansion and Phenotypic Profile Are Reflected in the CDR3δ Repertoire of Healthy Adults Anna Vyborova, Anke Janssen, Lucrezia Gatti, Froso Karaiskaki, Austin Yonika, Sanne van Dooremalen, Jasper Sanders, Dennis X Beringer, Trudy Straetemans, Zsolt Sebestyen, Jürgen Kuball
Frontiers in Immunology, 2022, vol. 13, p.1-13

Characterization and modulation of anti-alpha beta TCR antibodies and their respective binding sites at the beta TCR chain to enrich engineered T cells Guido J J Kierkels, Eline van Diest, Patricia Hernández-López, Wouter Scheper, Anja C M de Bruin, Elselien Frijlink, Tineke Aarts-Riemens, Sanne F J van Dooremalen, Dennis X Beringer, Rimke Oostvogels, Lovro Kramer, Trudy Straetemans, Wolfgang Uckert, Zsolt Sebestyén, Jürgen Kuball
Molecular Therapy - Methods and Clinical Development, 2021, vol. 22, p.388-400

Adding Help to an HLA-A*24:02 Tumor-Reactive gamma delta TCR Increases Tumor Control Inez Johanna, Patricia Hernández-López, Sabine Heijhuurs, Wouter Scheper, Laura Bongiovanni, Alain de Bruin, Dennis X. Beringer, Rimke Oostvogels, Trudy Straetemans, Zsolt Sebestyen, Jürgen Kuball
Frontiers in Immunology, 2021, vol. 12, p.1-12