Profile photo Denise van Hout

Denise van Hout

Researcher/Postdoc

Strategic program(s):

Biography

Denise van Hout is a medical doctor and epidemiologist working as a post-doctoral researcher at the Julius Center for Health Sciences, UMC Utrecht. She wrote a PhD thesis on infectious diseases epidemiology and is experienced in collaborating with international researchers in large consortia. In her post-doctoral research she uses data-driven to identify and quantify bottlenecks in the initiation and delivery of randomized clinical trials (RCTs), including adaptive platform trials (APTs), both in the Netherlands and in multinational settings. In addition, she is passionate about creating a more efficient and harmonized research landscape for the future and during health emergencies, such as pandemics. With her work she intends to reduce resource waste and improve the speed with which patients get access to innovative treatments.

Recent publications

Hurdles for the Delivery of Multinational Randomized Clinical Trials Denise van Hout, Paul Mouncey, David Harrison, Marc Bonten, Lennie Derde, Derek C Angus, Aisha Anjum, Djillali Annane, Janis Best-Lane, Frank Brunkhorst, Maurizio Cecconi, Stephan Ehrmann, Anthony Gordon, Leanne Marie Hays, Esmee Kester, Niamh Mahon, Colin McArthur, Alistair Nichol, Svenja Peters, Sara Pugliese, Kathryn Rowan, Julian Torre-Cisneros, Sebastian Weis,
JAMA network open, 2025, vol. 8
Influenza Infection and Acute Myocardial Infarction Annemarijn R de Boer, Annelies Riezebos-Brilman, Denise van Hout, Maaike S M van Mourik, Lidewij W Rümke, Marieke L A de Hoog, Ilonca Vaartjes, Patricia C J L Bruijning-Verhagen
NEJM evidence, 2024, vol. 3
Comparative genomics of ESBL-producing Escherichia coli (ESBL-Ec) reveals a similar distribution of the 10 most prevalent ESBL-Ec clones and ESBL genes among human community faecal and extra-intestinal infection isolates in the Netherlands (2014-17) T D Verschuuren, D van Hout, S Arredondo-Alonso, A C Fluit, E A Reuland, J Top, A C Schürch, T Bosch, M J M Bonten, J A J W Kluytmans, R J L Willems
The Journal of antimicrobial chemotherapy, 2021, vol. 76, p.901-908
Universal risk assessment upon hospital admission for screening of carriage with multidrug-resistant micro-organisms in a Dutch tertiary care centre Denise van Hout, Patricia C J Bruijning-Verhagen, Hetty Blok, Annet Troelstra, Marc J M Bonten
The journal of Hospital Infection, 2021, vol. 109, p.32-39
Extended-spectrum beta-lactamase (ESBL)-producing and non-ESBL-producing Escherichia coli isolates causing bacteremia in the Netherlands (2014 - 2016) differ in clonal distribution, antimicrobial resistance gene and virulence gene content Denise van Hout, Tess D Verschuuren, Patricia C J Bruijning-Verhagen, Thijs Bosch, Anita C Schürch, Rob J L Willems, Marc J M Bonten, Jan A J W Kluytmans
PLoS ONE, 2020, vol. 15, p.1-14
Microevolution of acquired colistin resistance in Enterobacteriaceae from ICU patients receiving selective decontamination of the digestive tract Axel B Janssen, Denise van Hout, Marc J M Bonten, Rob J L Willems, Willem van Schaik
The Journal of antimicrobial chemotherapy, 2020, vol. 75, p.3135-3143