Profile photo Alberto De Luca

Alberto De Luca

Assistant Professor

Strategic program(s):

Biography

Alberto De Luca is an assistant professor at the Image Sciences Institute (ISI), Division Imaging & Oncology. Alberto studied at the University of Padova, Italy, where he received a BSc in Biomedical Engineering (2011), an MSc in Bioengineering (2013) and a Ph.D. degree (2017) defending a thesis entitled "Beyond DTI: non-Gaussian diffusion in the brain and skeletal muscle".

Alberto's research focuses on diffusion magnetic resonance imaging (MRI) methods, and their translation to clinical research, especially in the context of neurological diseases such as small vessel disease (in close collaboration with the Neurology Department - VCI Group), and cancer. Current key research interests are:

  • Methods to quantify fiber specific properties in grey and white matter and accurately study brain connectivity;
  • Harmonization of diffusion MRI data to enable large multi-center studies;
  • Robust quantification of physiological properties (such as perfusion and free water) with inverse methods;
  • Prediction of response to treatment in rare pediatric tumours (in collaboration with the Prinses Maxima Centrum, Utrecht) and in brain tumours;
  • Prediction of clinical outcomes (such as cognitive decline) in patients at risk of (vascular) dementia machine learning;

Alberto has previously received funding from the Italian Ministry of Health, the Kika Foundation and Hanarth Fonds, and has received the "Seal of Excellence" from the European Commission. 

Research groups

Image sciences institute

Research aim

Our aim is to develop and evaluate medical image analysis and acquisition methods that help to answer research questions relevant to the strategic research programs, and that will benefit clinical imaging and image-guided interventions.

Go to group

Translational neuroimaging group

Research aim

To develop and apply advanced MRI methods for (pre)clinical research on neuronal and cerebrovascular biology in order to: 1) unravel critical aspects of brain impairment and recovery 2) advance brain treatments (focus: cerebrovascular diseases).

Go to group

Recent publications

Diffusion MRI of the prenatal fetal brain M Di Stefano, T Ciceri, A Leemans, S M C de Zwarte, A De Luca, D Peruzzo
NeuroImage, 2025, vol. 320
Evaluation of harmonization strategies for analyzing multi-center diffusion MRI data of rhabdomyosarcoma Andrey Zhylka, Giulia de Donno, Cyrano Chatziantoniou, Roelof van Ewijk, Madeleine Adams, Patrizia Bertolini, Gianni Bisogno, Amine Bouhamama, Pablo Caro-Dominguez, Valerie Charon, Ana Coma, Rana Dandis, Christine Devalck, Andrea Ferrari, Giulia Fichera, Marta Fiocco, Soledad Gallego, Heidi Glosli, Simone ter Horst, Meriel Jenney, Willemijn M. Klein, Julie Leseur, Henry C Mandeville, Kieran McHugh, Veronique Minard-Colin, Salma Moalla, Carlo Morosi, Daniel Orbach, Lise S. Ording Müller , Erika Pace, Pier Luigi Di Paolo, Katia Perruccio, Lucia Quaglietta, Marleen Renard, Antonio Ruggiero, Sara I. Sirvent, Reineke A Schoot, Rick R. Van Rijn, Johannes H.M. Merks, Alexander Leemans, A De Luca
2025
Feasibility of strong diffusion encoding and fast readout using a plug-and-play head gradient insert at 7 T G C Arends, E Versteeg, A De Luca, F Marc, T H M Roos, D W J Klomp, M Froeling, J C W Siero, C M W Tax
Magnetic Resonance in Medicine, 2025, vol. 94, p.2304-2316
The tractographer's dilemma Flavio Dell'Acqua, Alexander Leemans, Fan Zhang, Francois Rheault, Shawna Farquharson, Alberto De Luca
Brain structure & function, 2025, vol. 230
Acquisition matters - how do scan parameters affect apparent diffusion coefficient estimates in pediatric rhabdomyosarcoma Cyrano Chatziantoniou, Roelof van Ewijk, Madeleine Adams, Patrizia Bertolini, Gianni Bisogno, Amine Bouhamama, Pablo Caro-Dominguez, Valérie Charon, Ana Coma, Rana Dandis, Christine Devalck, Giulia De Donno, Andrea Ferrari, Marta Fiocco, Soledad Gallego, Chiara Giraudo, Heidi Glosli, Simone A J Ter Horst, Meriel Jenney, Willemijn M Klein, Alexander Leemans, Julie Leseur, Henry C Mandeville, Kieran McHugh, Johannes H M Merks, Veronique Minard-Colin, Salma Moalla, Carlo Morosi, Daniel Orbach, Lil-Sofie Ording Müller, Erika Pace, Pier Luigi Di Paolo, Katia Perruccio, Lucia Quaglietta, Marleen Renard, Rick R van Rijn, Antonio Ruggiero, Sara I Sirvent, Reineke A Schoot, Alberto De Luca
Pediatric radiology, 2025, vol. 55, p.1598-1610
MRI and non-MRI quantifiable neuroanatomical and functional parameters are useful for tractography Simona Schiavi, Elena Borra, Alberto De Luca, Derek K. Jones, Laurent Petit, Diego Szczupak
Brain Structure and Function, 2025, vol. 230

External positions

Member - Coordinating relations with industry and involved in funding opportunities - International Society for Tractography

Guest lecturer - I deliver a class about brain networks - Hogeschool Utrecht

Research collaboration on Frontotemporal dementia - Collaboration, research advisor, PhD supervision - Erasmus MC

Project collaboration on research in small vessel disease - Collaboration, research advisor, PhD supervision - University of Edinburgh

Member - Educational lectures, moderation of talks, mentoring of new members - International Society for Magnetic Resonance in Medicine (

Collaboration on research about rare pediatric tumors - Collaboration, research advisor, PhD supervision - Princess Maxima Center for Pediatric Oncology