Profile photo Alberto De Luca

Alberto De Luca

Associate Professor

Strategic program(s):

Biography

Alberto De Luca is an assistant professor at the Image Sciences Institute (ISI), Division Imaging & Oncology. Alberto studied at the University of Padova, Italy, where he received a BSc in Biomedical Engineering (2011), an MSc in Bioengineering (2013) and a Ph.D. degree (2017) defending a thesis entitled "Beyond DTI: non-Gaussian diffusion in the brain and skeletal muscle".

Alberto's research focuses on diffusion magnetic resonance imaging (MRI) methods, and their translation to clinical research, especially in the context of neurological diseases such as small vessel disease (in close collaboration with the Neurology Department - VCI Group), and cancer. Current key research interests are:

  • Methods to quantify fiber specific properties in grey and white matter and accurately study brain connectivity;
  • Harmonization of diffusion MRI data to enable large multi-center studies;
  • Robust quantification of physiological properties (such as perfusion and free water) with inverse methods;
  • Prediction of response to treatment in rare pediatric tumours (in collaboration with the Prinses Maxima Centrum, Utrecht) and in brain tumours;
  • Prediction of clinical outcomes (such as cognitive decline) in patients at risk of (vascular) dementia machine learning;

Alberto has previously received funding from the Italian Ministry of Health, the Kika Foundation and Hanarth Fonds, and has received the "Seal of Excellence" from the European Commission. 

Research groups

Image sciences institute

Research aim

Our aim is to develop and evaluate medical image analysis and acquisition methods that help to answer research questions relevant to the strategic research programs, and that will benefit clinical imaging and image-guided interventions.

Go to group

Translational neuroimaging group

Research aim

To develop and apply advanced MRI methods for (pre)clinical research on neuronal and cerebrovascular biology in order to: 1) unravel critical aspects of brain impairment and recovery 2) advance brain treatments (focus: cerebrovascular diseases).

Go to group

Recent publications

Critical and non-critical connections not differently associated with either Alzheimer's disease or vascular pathologies Naomi Vlegels, Bruno M de Brito Robalo, Alberto de Luca, Wiesje M van der Flier, Randall Bateman, Tammie L S Benzinger, Carlos Cruchaga, Dave M Cash, Hiroshi Mori, Igor Yakushev, Marco Duering, Sofia Finsterwalder, Benno Gesierich, Anna Kopczak, Yael D Reijmer, Geert Jan Biessels,
2026
Structural Fiber Tract Alterations in Relation to Surgery in Children With a Posterior Fossa Tumor Pien E  J Jellema, Jannie P Wijnen, Karina J Kersbergen, Martijn Froeling, Maarten H Lequin, Wouter P Nieuwenhuis, Alberto De Luca, Eelco W Hoving
NMR in Biomedicine, 2026, vol. 39
Individualized functionnectome for the statistical assessment of white matter circuits underlying task-fMRI activations in glioma patients Giovanni Sighinolfi, Alexander Leemans, David Neil Manners, Elena Cantoni, Gianfranco Vornetti, Lorenzo Motta, Enrico Franceschi, Caterina Tonon, Raffaele Lodi, Alberto De Luca
NeuroImage. Clinical, 2025, vol. 49
Biomarkers Francesca M. Chappell, Roberto Duarte, Maria Del C.Valdes Hernandez, Rosalind Brown, Jose Bernal, Lucia Ballerini, Joel Ramirez, Stephanie Berberian, Lauren Abby Woods, Hugo Kuijf, Alberto De Luca, Geert Jan Biessels, Sandra E. Black, Joanna M. Wardlaw
Alzheimer's & dementia : the journal of the Alzheimer's Association, 2025, vol. 21
Structural brain changes in subacute spinal cord injury Ernst Christiaanse, Jothini Sritharan, Patrik O Wyss, Anke Scheel-Sailer, Alexander Leemans, Rajeev K Verma, Alberto De Luca, Giuseppe A Zito
Frontiers in Neuroscience, 2025, vol. 19
A Community Benchmark for the Automated Segmentation of Pediatric Neuroblastoma on Multi-Modal MRI Myrthe A.D. Buser, Dominique C. Simons, Matthijs Fitski, Marc H.W.A. Wijnen, Annemieke S. Littooij, Annemiek H. ter Brugge, Iris N. Vos, Markus H.A. Janse, Mathijs de Boer, Rens ter Maat, Junya Sato, Shoji Kido, Satoshi Kondo, Satoshi Kasai, Marek Wodzinski, Henning Müller, Jin Ye, Junjun He, Yannick Kirchhoff, Maximilian R. Rokkus, Gao Haokai, Matías Fernández-Patón, Diana Veiga-Canuto, David G. Ellis, Michele Aizenberg, Bas H.M. van der Velden, Hugo Kuijf, Alberto de Luca, Alida F.W. van der Steeg
Bioengineering, 2025, vol. 12

External positions

Member - Coordinating relations with industry and involved in funding opportunities - International Society for Tractography

Guest lecturer - I deliver a class about brain networks - Hogeschool Utrecht

Research collaboration on Frontotemporal dementia - Collaboration, research advisor, PhD supervision - Erasmus MC

Project collaboration on research in small vessel disease - Collaboration, research advisor, PhD supervision - University of Edinburgh

Member - Educational lectures, moderation of talks, mentoring of new members - International Society for Magnetic Resonance in Medicine (

Collaboration on research about rare pediatric tumors - Collaboration, research advisor, PhD supervision - Princess Maxima Center for Pediatric Oncology