Tobias Dansen

Associate Professor

Strategic program(s):

Contact

tdansen@umcutrecht.nl

Pure profile

Research groups

Redox signaling & oxidative stress in cancer biology

Research aim

We study how reactive oxygen species mediate redox signaling and oxidative damage, how the cell senses and responds to signaling and damage differentially, and how deregulation of these processes can contribute to cancer development and therapy.

Go to group

Recent publications

All publications

Mitochondrial H2O2 release does not directly cause damage to chromosomal DNA. Daan M K van Soest, Paulien E Polderman, Wytze T F den Toom, Janneke P Keijer, Markus J van Roosmalen, Tim M F Leyten, Johannes Lehmann, Susan Zwakenberg, Sasha De Henau, Ruben van Boxtel, Boudewijn M T Burgering, Tobias B Dansen
Nature Communications, 2024, vol. 15, p.1-16

FOXO transcription factors as mediators of stress adaptation Maria J. Rodriguez-Colman, Tobias B. Dansen, Boudewijn M.T. Burgering
Nature reviews molecular cell biology, 2024, vol. 25, p.46-64

Oxygen-consumption based quantification of chemogenetic H₂O₂ production in live human cells Wytze T.F. den Toom, Daan M.K. van Soest, Paulien E. Polderman, Miranda H. van Triest, Lucas J.M. Bruurs, Sasha De Henau, Boudewijn M.T. Burgering, Tobias B. Dansen
Free Radical Biology and Medicine, 2023, vol. 206, p.134-142

A FOXO-dependent replication checkpoint restricts proliferation of damaged cells Marten Hornsveld, Femke M. Feringa, Lenno Krenning, Jeroen van den Berg, Lydia M.M. Smits, Nguyen B.T. Nguyen, Maria J. Rodríguez-Colman, Tobias B. Dansen, René H. Medema, Boudewijn M.T. Burgering
Cell Reports, 2021, vol. 34

DNA damage and oxidant stress activate p53 through differential upstream signaling pathways Tao Shi, Daan M.K. van Soest, Paulien E. Polderman, Boudewijn M.T. Burgering, Tobias B. Dansen
Free Radical Biology and Medicine, 2021, vol. 172, p.298-311

The human 2-cys peroxiredoxins form widespread, cysteine-dependent-and isoform-specific protein-protein interactions Loes van Dam, Marc Pagès-Gallego, Paulien E. Polderman, Robert M. van Es, Boudewijn M.T. Burgering, Harmjan R. Vos, Tobias B. Dansen
Antioxidants, 2021, vol. 10