Dani Heesterbeek

Assistant Professor

Strategic program(s):

Contact

dheeste2@umcutrecht.nl

Pure profile

Research groups

Bacterial infections & immunity

Research aim

To contribute to development of anti-bacterial immunotherapies by providing a scientific understanding of the mechanisms by which antibodies and complement induce bacterial immune clearance.

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Recent publications

All publications

Pmap-37 Fatemeh Pashaie, Naomi Benne, Philippa I P Holzapfel, Tineke Veenendaal, Floris J Bikker, Dani A C Heesterbeek, Femke Broere, Edwin J A Veldhuizen
Microbial pathogenesis, 2025, vol. 204

Human OTULIN haploinsufficiency impairs cell-intrinsic immunity to staphylococcal α-toxin András N. Spaan, Anna Lena Neehus, Emmanuel Laplantine, Frederik Staels, Masato Ogishi, Yoann Seeleuthner, Franck Rapaport, Keenan A. Lacey, Erika Van Nieuwenhove, Maya Chrabieh, David Hum, Mélanie Migaud, Araksya Izmiryan, Lazaro Lorenzo, Tatiana Kochetkov, Dani A.C. Heesterbeek, Bart W. Bardoel, Ashley L. DuMont, Kerry Dobbs, Solenne Chardonnet, Søren Heissel, Timour Baslan, Peng Zhang, Rui Yang, Dusan Bogunovic, Herman F. Wunderink, Pieter Jan A. Haas, Henrik Molina, Griet Van Buggenhout, Stanislas Lyonnet, Luigi D. Notarangelo, Mikko R.J. Seppänen, Robert Weil, Gisela Seminario, Héctor Gomez-Tello, Carine Wouters, Mehrnaz Mesdaghi, Mohammad Shahrooei, Xavier Bossuyt, Erdal Sag, Rezan Topaloglu, Seza Ozen, Helen L. Leavis, Maarten M.J. van Eijk, Liliana Bezrodnik, Lizbeth Blancas Galicia, Alain Hovnanian, Aude Nassif, Brigitte Bader-Meunier, Bénédicte Neven, Isabelle Meyts, Rik Schrijvers, Anne Puel, Jacinta Bustamante, Ivona Aksentijevich, Daniel L. Kastner, Victor J. Torres, Stéphanie Humblet-Baron, Adrian Liston, Laurent Abel, Bertrand Boisson, Jean Laurent Casanova
Science, 2022, vol. 376

Outer membrane permeabilization by the membrane attack complex sensitizes Gram-negative bacteria to antimicrobial proteins in serum and phagocytes Dani A.C. Heesterbeek, Remy M. Muts, Vincent P. van Hensbergen, Pieter de Saint Aulaire, Tom Wennekes, Bart W. Bardoel, Nina M. van Sorge, Suzan H.M. Rooijakkers
PLoS Pathogens, 2021, vol. 17

Publisher Correction D. A.C. Heesterbeek, N. I. Martin, A. Velthuizen, M. Duijst, M. Ruyken, R. Wubbolts, S. H.M. Rooijakkers, B. W. Bardoel
Scientific Reports, 2019, vol. 9

Complement-dependent outer membrane perturbation sensitizes Gram-negative bacteria to Gram-positive specific antibiotics D. A.C. Heesterbeek, N. I. Martin, A. Velthuizen, M. Duijst, M. Ruyken, R. Wubbolts, S. H.M. Rooijakkers, B. W. Bardoel
Scientific Reports, 2019, vol. 9

Complement and Bacterial Infections Dani A.C. Heesterbeek, Mathieu L. Angelier, Richard A. Harrison, Suzan H.M. Rooijakkers
Journal of Innate Immunity, 2018, vol. 10, p.455-464