Profile photo Olaf Cremer

Olaf Cremer

Full Professor

Strategic program(s):

Biography

Olaf Cremer (1971) was trained as an anesthesiologist, intensivist and clinical epidemiologist. He has worked as a consultant in the department of intensive care medicine of the UMCU since 2007. Dr. Cremer has designed and co-developed the patient data management system that is currently in use. His detailed knowledge of the system and computer programming skills allow him to explore this clinical database as a rich source of information for several research projects within the division.
Prof. Cremer obtained his PhD degree in 2005 with a doctoral thesis on goal-directed management of patients with severe traumatic brain injury. His thesis included both experimental clinical studies focused on cerebrovascular pathophysiology, as well as large cohort studies focused on patient outcomes. Since 2010 he has been studying the clinical epidemiology of infections in the ICU and/or the postoperative setting. He is one of the PI's of the MARS consortium, a multicentre collaboration aimed at developing new molecular technologies for early diagnosis and risk stratification of sepsis. More recently he initiated the PLUTO project, a longitudinal biorepository of patients undergoing elective surgery in the UMCU. The main focus areas of his research group include:

1 - diagnostic uncertainty in early detection of sepsis

2 - attributable morbidity and mortality of (nosocomial) sepsis and acute inflammation

3 - decision support for diagnosis and treatment of sepsis

Cremer has been mentoring 20 PhD students to date.

Research groups

Epidemiology of sepsis & inflammation in critically ill patients

Research aim

We design and conduct clinical epidemiological research focused on risk stratification, early diagnosis, and novel treatment of critically ill patients with severe infections.

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Recent publications

Clinical subtypes in critically ill patients with sepsis Rombout B E van Amstel, Emma Rademaker, Jason N Kennedy, Lieuwe D J Bos, Hessel Peters-Sengers, Joe M Butler, Niklas Bruse, Dave A Dongelmans, Matthijs Kox, Alexander P J Vlaar, Tom van der Poll, Olaf L Cremer, Christopher W Seymour, Lonneke A van Vught
Critical care (London, England), 2025, vol. 29
Glycan-specific IgM is critical for human immunity to Staphylococcus aureus Astrid Hendriks, Priscilla F Kerkman, Meri R J Varkila, Jelle L G Haitsma Mulier, Sara Ali, Thijs Ten Doesschate, Thomas W van der Vaart, Carla J C de Haas, Piet C Aerts, Olaf L Cremer, Marc J M Bonten, Victor Nizet, George Y Liu, Jeroen D C Codée, Suzan H M Rooijakkers, Jos A G van Strijp, Nina M van Sorge
Cell reports. Medicine, 2024, vol. 5
The Plasma Lipidomic Landscape in Patients with Sepsis due to Community-acquired Pneumonia Osoul Chouchane, Alex R Schuurman, Tom D Y Reijnders, Hessel Peters-Sengers, Joe M Butler, Fabrice Uhel, Marcus J Schultz, Marc J Bonten, Olaf L Cremer, Carolyn S Calfee, Michael A Matthay, Raymond J Langley, Narges Alipanah-Lechner, Stephen F Kingsmore, Angela Rogers, Michel van Weeghel, Frédéric M Vaz, Tom van der Poll
American Journal of Respiratory and Critical Care Medicine, 2024, vol. 209, p.973-986
High PEEP/low FiO2 ventilation is associated with lower mortality in COVID–19 Robin L Goossen, Relin van Vliet, Lieuwe D J Bos, Laura A Buiteman-Kruizinga, Markus W Hollman, Sheila N Myatra, Ary Serpa Neto, Peter E Spronk, Meta C E van der Woude, David M P van Meenen, Frederique Paulus, Marcus J Schultz, , Olaf Cremer
Journal of Critical Care, 2024, vol. 83
Clinical Subtype Trajectories in Sepsis Patients Admitted to the ICU Marleen A Slim, Rombout B E van Amstel, Marcella C A Müller, Olaf L Cremer, Alexander P J Vlaar, Tom van der Poll, W Joost Wiersinga, Christopher W Seymour, Lonneke A van Vught
Critical care explorations, 2024, vol. 6
Monocyte state 1 (MS1) cells in critically ill patients with sepsis or non-infectious conditions Giuseppe G F Leite, Justin de Brabander, Erik H A Michels, Joe M Butler, Olaf L Cremer, Brendon P Scicluna, Timothy E Sweeney, Miguel Reyes, Reinaldo Salomao, Hessel Peters-Sengers, Tom van der Poll
Critical care (London, England), 2024, vol. 28

External positions

External Project Advisory Committee - provide independent expert advice and strategic guidance to the project management board - BEATsep Consortium (EU)

Member of the Council for Science & Innovation (Raad W&I) - Advisor and liason officer for the Dutch Society for Intensive Care - Federatie van Medisch Specialisten

Chairman of the Science & Innovation Committee - Developing a Knowledge Agenda for the Intensive Care - Nederlandse Vereniging voor Intensive Care (NVIC)