Profile photo Olaf Cremer

Olaf Cremer

Full Professor

Strategic program(s):

Biography

Olaf Cremer (1971) was trained as an anesthesiologist, intensivist and clinical epidemiologist. He has worked as a consultant in the department of intensive care medicine of the UMCU since 2007. Dr. Cremer has designed and co-developed the patient data management system that is currently in use. His detailed knowledge of the system and computer programming skills allow him to explore this clinical database as a rich source of information for several research projects within the division.
Prof. Cremer obtained his PhD degree in 2005 with a doctoral thesis on goal-directed management of patients with severe traumatic brain injury. His thesis included both experimental clinical studies focused on cerebrovascular pathophysiology, as well as large cohort studies focused on patient outcomes. Since 2010 he has been studying the clinical epidemiology of infections in the ICU and/or the postoperative setting. He is one of the PI's of the MARS consortium, a multicentre collaboration aimed at developing new molecular technologies for early diagnosis and risk stratification of sepsis. More recently he initiated the PLUTO project, a longitudinal biorepository of patients undergoing elective surgery in the UMCU. The main focus areas of his research group include:

1 - diagnostic uncertainty in early detection of sepsis

2 - attributable morbidity and mortality of (nosocomial) sepsis and acute inflammation

3 - decision support for diagnosis and treatment of sepsis

Cremer has been mentoring 18 PhD students to date.

Research groups

Epidemiology of sepsis & inflammation in critically ill patients

Research aim

We design and conduct clinical epidemiological research focused on risk stratification, early diagnosis, and novel treatment of critically ill patients with severe infections.

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Recent publications

The Plasma Lipidomic Landscape in Patients with Sepsis due to Community-acquired Pneumonia Osoul Chouchane, Alex R Schuurman, Tom D Y Reijnders, Hessel Peters-Sengers, Joe M Butler, Fabrice Uhel, Marcus J Schultz, Marc J Bonten, Olaf L Cremer, Carolyn S Calfee, Michael A Matthay, Raymond J Langley, Narges Alipanah-Lechner, Stephen F Kingsmore, Angela Rogers, Michel van Weeghel, Frédéric M Vaz, Tom van der Poll
American Journal of Respiratory and Critical Care Medicine, 2024, vol. 209, p.973-986
Monocyte state 1 (MS1) cells in critically ill patients with sepsis or non-infectious conditions Giuseppe G F Leite, Justin de Brabander, Erik H A Michels, Joe M Butler, Olaf L Cremer, Brendon P Scicluna, Timothy E Sweeney, Miguel Reyes, Reinaldo Salomao, Hessel Peters-Sengers, Tom van der Poll
Critical care (London, England), 2024, vol. 28
Examining pancreatic stone protein response in ICU-acquired bloodstream infections Diede Verlaan, Lennie P G Derde, Tom van der Poll, Marc J M Bonten, Olaf L Cremer
Intensive Care Medicine Experimental, 2024, vol. 12
Biomarker patterns in patients with cardiogenic shock versus septic shock Elma J. Peters, Martin S. Frydland, Christian Hassager, Lieuwe D.J. Bos, Lonneke A. van Vught, Olaf L. Cremer, Jacob E. Møller, Bert Jan H. van den Born, Alexander P.J. Vlaar, Jose P.S. Henriques
IJC Heart and Vasculature, 2024, vol. 52
Inflammatory subphenotypes previously identified in ARDS are associated with mortality at intensive care unit discharge Marleen A. Slim, Rombout B.E. van Amstel, Lieuwe D.J. Bos, Olaf L. Cremer, W. Joost Wiersinga, Tom van der Poll, Lonneke A. van Vught
Critical Care, 2024, vol. 28
Longitudinal assessment of immunoglobulin response and disease progression in critically ill patients with community acquired pneumonia Emma Rademaker, Lisette M Vernooij, Tom van der Poll, Marc J M Bonten, Helen Leavis, Olaf L Cremer, Lennie P G Derde
Critical care (London, England), 2024, vol. 28

External positions

External Project Advisory Committee - provide independent expert advice and strategic guidance to the project management board - BEATsep Consortium (EU)

Member of the Council for Science & Innovation (Raad W&I) - Advisor and liason officer for the Dutch Society for Intensive Care - Federatie van Medisch Specialisten

Chairman of the Science & Innovation Committee - Developing a Knowledge Agenda for the Intensive Care - Nederlandse Vereniging voor Intensive Care (NVIC)