Laura Creemers

Associate Professor

Strategic program(s):

Biography

Dr Creemers studied  Biomedical Sciences in Leiden and has worked in several research areas, including spermatogenic stem cells, (periodontal) ligament, tendon and bone. Since 2005 her focus is on cartilage and intervertebral disc research with a special interest in biomaterials-based local delivery approaches for regeneration and treatment of inflammation. Delivery includes small molecules, proteins, peptides and nucleic acids, research approaches involve biological effects, pharmacokinetics and imaging,using  in vitro and in vivo models, the latter in close collaboration with the dept of Companion Animals at the Fac Veterinary Medicine. She is author on over 90 peer-reviewed publications and has in the past years been involved in several projects on local delivery, including BMM IdiDAS (9.2 M€; PI) targeting disc degeneration, BMM-OAcontrol on osteoarthritis and LSH –ArIADNE (1.2 M€;PI), where local delivery of anti-inflammatory mediators in osteoarthritis and intervertebral disc degeneration is further being taken towards clinical translation. In addition she is involved in H2020 ITN-TargetCaRe on targeted delivery in intervertebral disc and cartilage regeneration.

Recent publications

Biological Sex Is Under-Reported in Cartilage-Related Preclinical Research Daniele Zuncheddu, Paola Buedo, Martin J Stoddart, Laura B Creemers, Sibylle Grad, Marcin Waligora
JOR spine, 2025, vol. 8
In vitro and in vivo delivery of mRNA to joint cells using polymeric nanoparticles Adriano P Pontes, Jaqueline Lourdes Rios, Mattie Rijker, Kelly Warmink, Shreya Gudi, Francisco Conceição, Björn Meij, Tim J M Welting, Liliana Moreira Teixeira, Jaap Rip, Laura B Creemers
Acta Biomaterialia, 2025, vol. 202, p.418-434
Mesenchymal stromal cell injections for osteoarthritis Marta Santolini, Jaqueline Lourdes Rios, Roel J H Custers, Laura B Creemers, Jasmijn V Korpershoek
The Knee, 2025, vol. 56, p.267-275
Antibody and aptamer-based therapies for osteoarthritis Huaizhi Chen, Zijian Ye, Jasmijn V. Korpershoek, Laura B. Creemers, Harrie Weinans, Jaqueline Lourdes Rios
Molecular Therapy Nucleic Acids, 2025, vol. 36
Establishment of an ex vivo cartilage damage model by combined collagenase treatment and mechanical loading Liru Wen, Sibylle Grad, Laura B Creemers, Martin J Stoddart
Arthritis research & therapy, 2025, vol. 27
ADAMTS5-specific gapmer release from an albumin biomolecular assembly and cartilage internalization triggered by ultrasound Marwa Elkhashab, Goncalo Barreto, Yohann Le Bourlout, Laura B Creemers, Heikki J Nieminen, Kenneth A Howard
Drug delivery, 2025, vol. 32

Fellowships & Awards

Co-awardee ‘Mathijsen award’ to R Custers (2011) and KG Auw Yang (2009) by the Dutch Orthopaedic Society for the best PhD thesis