Laura Creemers

Associate Professor

Strategic program(s):

Biography

Dr Creemers studied  Biomedical Sciences in Leiden and has worked in several research areas, including spermatogenic stem cells, (periodontal) ligament, tendon and bone. Since 2005 her focus is on cartilage and intervertebral disc research with a special interest in biomaterials-based local delivery approaches for regeneration and treatment of inflammation. Delivery includes small molecules, proteins, peptides and nucleic acids, research approaches involve biological effects, pharmacokinetics and imaging,using  in vitro and in vivo models, the latter in close collaboration with the dept of Companion Animals at the Fac Veterinary Medicine. She is author on over 90 peer-reviewed publications and has in the past years been involved in several projects on local delivery, including BMM IdiDAS (9.2 M€; PI) targeting disc degeneration, BMM-OAcontrol on osteoarthritis and LSH –ArIADNE (1.2 M€;PI), where local delivery of anti-inflammatory mediators in osteoarthritis and intervertebral disc degeneration is further being taken towards clinical translation. In addition she is involved in H2020 ITN-TargetCaRe on targeted delivery in intervertebral disc and cartilage regeneration.

Recent publications

Drug retention after intradiscal administration Imke Rudnik-Jansen, Jie Du, Nina Karssemakers-Degen, Anna R Tellegen, Parvesh Wadhwani, Daniele Zuncheddu, Björn P Meij, Jens Thies, Pieter Emans, Fetullah C Öner, George Mihov, Joao Pedro Garcia, Anne S Ulrich, Sibylle Grad, Marianna A Tryfonidou, Hugo van Ingen, Laura B Creemers
Drug delivery, 2024, vol. 31
A Modular Albumin-Oligonucleotide Biomolecular Assembly for Delivery of Antisense Therapeutics Marwa Elkhashab, Yeter Dilek, Morten Foss, Laura B. Creemers, Kenneth A. Howard
Molecular pharmaceutics, 2024, vol. 21, p.491-500
NOGGIN INHIBITS TGF-β1 OR TGF-β3 INDUCED CHONDROGENESIS OF MESENCHYMAL STROMAL CELLS L. Wen, A. R. Armiento, A. G. Guex, S. Grad, L. Creemers, M. J. Stoddart
European Cells and Materials, 2024, vol. 47, p.142-151
Polymeric Nanoparticles Enable mRNA Transfection and Its Translation in Intervertebral Disc and Human Joint Cells, Except for M1 Macrophages Katrin Agnes Muenzebrock, Fiona Y W Ho, Adriano P Pontes, Carla Jorquera-Cordero, Lizette Utomo, Joao Pedro Garcia, Paul C Willems, Tim J M Welting, Jaap Rip, Laura B Creemers
Pharmaceutics, 2024, vol. 16
Biomolecular therapies for chronic discogenic low back pain Imke Rudnik-Jansen, Sanda van Kruining Kodele, Laura Creemers, Bert Joosten
JOR spine, 2024, vol. 7
A poly(amidoamine)-based polymeric nanoparticle platform for efficient in vivo delivery of mRNA Adriano P Pontes, Steffen van der Wal, Karin Roelofs, Anne Grobbink, Laura B Creemers, Johan F J Engbersen, Jaap Rip
Biomaterials advances, 2024, vol. 156