Caroline de Theije

Assistant Professor

Strategic program(s):

Contact

ctheije@umcutrecht.nl

Pure profile

Research groups

Protection and repair of the injured newborn brain

Research aim

Our mission is to unravel the impact of early life adversity, such as perinatal asphyxia and stroke, preterm birth and early life stress on brain development and to design strategies to improve outcome of affected infants, shaping a better future.

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Developmental origins of disease

Research aim

Our laboratory is dedicated to understanding how early life events, such as preterm birth and perinatal complications, influence brain development and long-term outcomes.

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Recent publications

All publications

Human milk oligosaccharides improve white matter and interneuron development in a double-hit rat model for preterm brain injury Myrna J V Brandt, Juliette Van Steenwinckel, Bobbie-Louise Van Emst, Julia Lohr, Marko Mank, Lidewij Schipper, Louise Harvey, Manon J N L Benders, Caroline G M de Theije
Neuropharmacology, 2025, vol. 276

Hypoxic Preconditioning Enhances the Potential of Mesenchymal Stem Cells to Treat Neonatal Hypoxic-Ischemic Brain Injury Sara T. De Palma, Eva C. Hermans, Tatiana M. Shamorkina, Chloe Trayford, Sabine van Rijt, Albert J.R. Heck, Cora H.A. Nijboer, Caroline G.M. de Theije
Stroke, 2025, vol. 56, p.1872-1882

Timed fetal inflammation and postnatal hypoxia cause cortical white matter injury, interneuron imbalances, and behavioral deficits in a double-hit rat model of encephalopathy of prematurity M. J.V. Brandt, C. M. Kosmeijer, E. J.M. Achterberg, C. G.M. de Theije, C. H. Nijboer
Brain, Behavior, and Immunity - Health, 2024, vol. 40

Dietary LPC-Bound n-3 LCPUFA Protects against Neonatal Brain Injury in Mice but Does Not Enhance Stem Cell Therapy. Eva C Hermans, Carlon C E van Gerven, Line Johnsen, Jørn E Tungen, Cora H Nijboer, Caroline G M de Theije
Nutrients, 2024, vol. 16

Dolphin CONTINUE E. Janson, P. C.M.P. Koolschijn, L. Schipper, T. D. Boerma, F. N.K. Wijnen, W. P. de Boode, C. H.P. van den Akker, R. G. Licht-van der Stap, D. H.G.M. Nuytemans, W. Onland, S. A. Obermann-Borst, J. Dudink, C. G.M. de Theije, M. J.N.L. Benders, N. E. van der Aa
BMC Pediatrics, 2024, vol. 24

Ultrasonic vocalization emission is altered following neonatal hypoxic-ischemic brain injury in mice Eva C Hermans, Caroline G M de Theije, Cora H Nijboer, E J Marijke Achterberg
Behavioural Brain Research, 2024, vol. 471