Bas Vastert

Associate Professor - medical

Strategic program(s):

Biography

Bas is a pediatric rheumatologist in the “EULAR center of excellence in rheumatology" Wilhelmina Children’s Hospital Utrecht. Besides being an esteemed clinician in the field of Pediatric Rheumatology, he has developed into a translational researcher, with a PhD on mechanisms of disease and therapy in severe JIA in 2013. From 2015, he has been starting a translational research group together with Jorg van Loosdregt, molecular biologist. They currently supervise 5 PhD students, 1 post-doc and 2 technicians together, within the Center of Translational Immunology in Utrecht (v Loosdregt-Vastert group). Their labgroup aims to translate cutting edge science into clinical benefit for patients and their research focusses on systemic JIA and on development of novel treatment strategies for JIA. Bas is currently leading a multi-center prospective trial implementing a biomarker driven stop-strategy for rIL-1RA therapy in systemic JIA in the Netherlands (the ESTIS trial).

In addition, as a designated Young Investigator, Bas is the Dutch lead for all translational laboratory studies within UCAN CAN DU (major infrastructural research project 2017-2021 in Canada and the Netherlands).

Key words: Translational research in childhood arthritis, biology of systemic JIA, (regulation of) auto-inflammation, regulation of autoimmune inflammation, epigenetics.

Strategic program(s):

Contact

bvastert@umcutrecht.nl

Pure profile

Research groups

Translational immunology

Research aim

It is our goal to improve the diagnosis and treatment of immune-related diseases with a focus on Juvenile Idiopathic Arthritis

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Recent publications

All publications

The 4th NextGen therapies for SJIA and MAS Grant Schulert, Sebastiaan J Vastert, Alexei A Grom
Pediatric rheumatology online journal, 2024, vol. 21

Serum proteomics reveals hemophagocytic lymphohistiocytosis-like phenotype in a subset of patients with multisystem inflammatory syndrome in children Adam J Tulling, Marloes G Holierhoek, Anja M Jansen-Hoogendijk, Levi Hoste, Filomeen Haerynck, Simon J Tavernier, Rianne Oostenbrink, Corinne M P Buysse, Michiel A G E Bannier, Jolita Bekhof, Mijke Breukels, Sanne C Hammer, Monique A M Jacobs, Arvid W A Kamps, Jan W van der Linden, Ankie Lebon, Johanna H Oudshoorn, Gerdien A Tramper-Stranders, Sebastiaan J Vastert, Jantien W Wieringa, Suzanne W J Terheggen-Lagro, Joanne G Wildenbeest, Erik G J von Asmuth, Erik B van den Akker, Marielle E van Gijn, Gertjan Lugthart, Emilie P Buddingh
Clinical Immunology, 2024, vol. 264

Humoral and cellular immunogenicity, effectiveness and safety of COVID-19 mRNA vaccination in patients with pediatric rheumatic diseases Mohamad Hamad Saied, Joeri W van Straalen, Sytze de Roock, Frans M Verduyn Lunel, Jelle de Wit, Lia G H de Rond, Erika Van Nieuwenhove, Bas J Vastert, Joris M van Montfrans, Annet van Royen-Kerkhof, Gerrie C J de Joode-Smink, Joost F Swart, Nico M Wulffraat, Marc H A Jansen
Vaccine, 2024, vol. 42, p.1145-1153

m⁶A Reader YTHDC1 Impairs Respiratory Syncytial Virus Infection by Downregulating Membrane CX3CR1 Expression Lucas W. Picavet, Ellen C.N. van Vroonhoven, Rianne C. Scholman, Yesper T.H. Smits, Rupa Banerjee, Sjanna B. Besteman, Mattheus C. Viveen, Michiel M. van der Vlist, Marvin E. Tanenbaum, Robert J. Lebbink, Sebastiaan J. Vastert, Jorg van Loosdregt
Viruses, 2024, vol. 16

CBP/P300 Inhibition Impairs CD4+ T Cell Activation Lucas Wilhelmus Picavet, Anoushka A K Samat, Jorg Calis, Lotte Nijhuis, Rianne Scholman, Michal Mokry, David F Tough, Rabinder K Prinjha, Sebastiaan J Vastert, Jorg van Loosdregt
Biomedicines, 2024, vol. 12

Managing juvenile idiopathic arthritis within the context of their life G. R. Currie, B. L. Kennedy, S. M. Benseler, Yeung R. S. M., J. F. Swart, S. J. Vastert, N. M. Wulffraat, Kip M. M. A., Gail MacKean, D. A. Marshall
Musculoskeletal Care, 2023, vol. 21, p.1248-1260

Fellowships & Awards

2020: Jeffrey Modell Foundation C.H.I.L.D.R.E.N! Research Program grant