Antoine Khalil

Assistant Professor

Strategic program(s):

Biography

Dr. Khalil performed his PhD studies in the lab of Peter Friedl at the University of Wurzburg, Germany and Radboudumc, Nijmegen, The Netherlands. Here, Antoine identified that collective invasion is a predominant mode of local spread in breast cancer patients and characterized the role of connexin channels in organizing the invading cells into leader and follower cells.

After finishing his PhD, dr. Khalil went to the lab of Johan de Rooij at the UMC Utrecht, where he pursued his investigations on cell invasion with focus on ECM mechanotransduction. Dr. Khalil investigated how cancer cells transduce biomechanical cues in the ECM and the underlying molecular mechanisms that promote invasive characteristics in particular subsets of cancer cells.

As of January 2022, Dr. Khalil functions as an assistant professor and is leading the group invasion of epithelial tumors at the Center for molecular medicine (CMM) in Utrecht UMC.

Strategic program(s):

Contact

akhalil@umcutrecht.nl

Pure profile

Research groups

Invasion of epithelial tumors

Research aim

Our goal is to uncover how cancer cells invade healthy tissues around tumors, driving local cancer spread and distant metastasis. Understanding cell invasion will guide targeted therapies to reduce tumor dissemination, enhancing patient outcomes.

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Recent publications

All publications

The extracellular matrix as hallmark of cancer and metastasis Jelle J.F. Sleeboom, Gilles S. van Tienderen, Katja Schenke-Layland, Luc J.W. van der Laan, Antoine A. Khalil, Monique M.A. Verstegen
Science translational medicine, 2024, vol. 16

A YAP-centered mechanotransduction loop drives collective breast cancer cell invasion Antoine A Khalil, Daan Smits, Peter D Haughton, Thijs Koorman, Karin A Jansen, Mathijs P Verhagen, Mirjam van der Net, Kitty van Zwieten, Lotte Enserink, Lisa Jansen, Abdelrahman G El-Gammal, Daan Visser, Milena Pasolli, Max Tak, Denise Westland, Paul J van Diest, Cathy B Moelans, M Guy Roukens, Sandra Tavares, Anne-Marie Fortier, Morag Park, Riccardo Fodde, Martijn Gloerich, Fried J T Zwartkruis, Patrick Wb Derksen, Johan de Rooij
Nature Communications, 2024, vol. 15

Lack of association between classical HLA genes and asymptomatic SARS-CoV-2 infection Astrid Marchal, Elizabeth T. Cirulli, Iva Neveux, Evangelos Bellos, Ryan S. Thwaites, Kelly M. Schiabor Barrett, Yu Zhang, Ivana Nemes-Bokun, Mariya Kalinova, Andrew Catchpole, Stuart G. Tangye, András N. Spaan, Justin B. Lack, Jade Ghosn, Charles Burdet, Guy Gorochov, Florence Tubach, Pierre Hausfater, Laurent Abel, Alessandro Aiuti, Saleh Al-Muhsen, Fahd Al-Mulla, Ali Amara, Mark S. Anderson, Evangelos Andreakos, Andrés A. Arias, Lisa M. Arkin, Hagit Baris Feldman, Paul Bastard, Alexandre Belot, Catherine M. Biggs, Dusan Bogunovic, Alexandre Bolze, Anastasiia Bondarenko, Alessandro Borghesi, Ahmed A. Bousfiha, Petter Brodin, Yenan Bryceson, Manish J. Butte, Jean Laurent Casanova, Giorgio Casari, John Christodoulou, Aurélie Cobat, Roger Colobran, Antonio Condino-Neto, Antoine Khalil, David T.P. Buis, Lucas Fleuren, Charlotte Teunissen, Marc van der Valk, , , , , , , , ,
Human Genetics and Genomics Advances, 2024, vol. 5

Characteristics and outcomes of COVID-19 patients admitted to hospital with and without respiratory symptoms Barbara Wanjiru Citarella, Christiana Kartsonaki, Elsa D. Ibáñez-Prada, Bronner P. Gonçalves, Joaquin Baruch, Martina Escher, Mark G. Pritchard, Jia Wei, Fred Philippy, Andrew Dagens, Matthew Hall, James Lee, Demetrios James Kutsogiannis, Evert Jan Wils, Marília Andreia Fernandes, Bharath Kumar Tirupakuzhi Vijayaraghavan, Prasan Kumar Panda, Ignacio Martin-Loeches, Shinichiro Ohshimo, Arie Zainul Fatoni, Peter Horby, Jake Dunning, Jordi Rello, Laura Merson, Amanda Rojek, Michel Vaillant, Piero Olliaro, Luis Felipe Reyes, S. A. Moharam, Sabriya Abdalasalam, Alaa Abdalfattah Abdalhadi, Naana Reyam Abdalla, Walaa Abdalla, Almthani Hamza Abdalrheem, Ashraf Abdalsalam, Saedah Abdeewi, Esraa Hassan Abdelgaum, Mohamed Abdelhalim, Mohammed Abdelkabir, Israa Abdelrahman, Sheryl Ann Abdukahil, Lamees Adil Abdulbaqi, Salaheddin Abdulhamid, Debby Bogaert, Juan Jose Diaz, Antoine Khalil, David S.Y. Ong, Douwe F. Postma, Paul van der Valk, Annelies Verbon,
Heliyon, 2024, vol. 10, p.1-16

Spatial collagen stiffening promotes collective breast cancer cell invasion by reinforcing extracellular matrix alignment Thijs Koorman, Karin A Jansen, Antoine Khalil, Peter D Haughton, Daan Visser, Max A K Rätze, Wisse E Haakma, Gabrielè Sakalauskaitè, Paul J van Diest, Johan de Rooij, Patrick W B Derksen
Oncogene, 2022, vol. 41, p.2458-2469

Regulation of a progenitor gene program by SOX4 is essential for mammary tumor proliferation M Guy Roukens, Cynthia L Frederiks, Danielle Seinstra, Luca Braccioli, Antoine A Khalil, Cornelieke Pals, Simon De Neck, Laura Bornes, Evelyne Beerling, Michal Mokry, Alain de Bruin, Bart Westendorp, Jacco van Rheenen, Paul J Coffer
Oncogene, 2021, vol. 40, p.6343-6353