Aniek Janssen

Associate Professor

Strategic program(s):

Contact

ajansse2@umcutrecht.nl

Pure profile

Research groups

Chromatin dynamics and genome instability

Research aim

We aim to understand how chromatin dynamics contributes to the maintenance of genome stability and how chromatin defects can contribute to genome instability and cancer development in the long run.

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Recent publications

All publications

The impact of chromatin on double-strand break repair Marit A E van Bueren, Aniek Janssen
DNA repair, 2024, vol. 133

Double-strand breaks in facultative heterochromatin require specific movements and chromatin changes for efficient repair Marieke R. Wensveen, Aditya A. Dixit, Robin van Schendel, Apfrida Kendek, Jan Paul Lambooij, Marcel Tijsterman, Serafin U. Colmenares, Aniek Janssen
Nature Communications, 2024, vol. 15

DNA double-strand break movement in heterochromatin depends on the histone acetyltransferase dGcn5 Apfrida Kendek, Arianna Sandron, Jan Paul Lambooij, Serafin U. Colmenares, Severina M. Pociunaite, Iris Gooijers, Lars de Groot, Gary H. Karpen, Aniek Janssen
Nucleic acids research, 2024, vol. 52, p.11753-11767

The Sound of Silence: How Silenced Chromatin Orchestrates the Repair of Double-Strand Breaks Apfrida Kendek, Marieke R. Wensveen, Aniek Janssen
Genes, 2021, vol. 12

Degree and site of chromosomal instability define its oncogenic potential Wilma H.M. Hoevenaar, Aniek Janssen, Ajit I. Quirindongo, Huiying Ma, Sjoerd J. Klaasen, Antoinette Teixeira, Bastiaan van Gerwen, Nico Lansu, Folkert H.M. Morsink, G. Johan A. Offerhaus, René H. Medema, Geert J.P.L. Kops, Nannette Jelluma
Nature Communications, 2020, vol. 11

Timely double-strand break repair and pathway choice in pericentromeric heterochromatin depend on the histone demethylase dKDM4A Aniek Janssen, Serafin U Colmenares, Timothy Lee, Gary H Karpen
Genes and Development, 2019, vol. 33, p.103-115