Aniek Janssen

Associate Professor

Strategic program(s):

Contact

ajansse2@umcutrecht.nl

Pure profile

Research groups

Chromatin dynamics and genome instability

Research aim

We aim to understand how chromatin dynamics contributes to the maintenance of genome stability and how chromatin defects can contribute to genome instability and cancer development in the long run.

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Recent publications

All publications

The impact of chromatin on double-strand break repair Marit A E van Bueren, Aniek Janssen
DNA repair, 2024, vol. 133

The Sound of Silence: How Silenced Chromatin Orchestrates the Repair of Double-Strand Breaks Apfrida Kendek, Marieke R. Wensveen, Aniek Janssen
Genes, 2021, vol. 12

Degree and site of chromosomal instability define its oncogenic potential Wilma H.M. Hoevenaar, Aniek Janssen, Ajit I. Quirindongo, Huiying Ma, Sjoerd J. Klaasen, Antoinette Teixeira, Bastiaan van Gerwen, Nico Lansu, Folkert H.M. Morsink, G. Johan A. Offerhaus, René H. Medema, Geert J.P.L. Kops, Nannette Jelluma
Nature Communications, 2020, vol. 11

Timely double-strand break repair and pathway choice in pericentromeric heterochromatin depend on the histone demethylase dKDM4A Aniek Janssen, Serafin U Colmenares, Timothy Lee, Gary H Karpen
Genes and Development, 2019, vol. 33, p.103-115

Inhibition of the spindle assembly checkpoint kinase TTK enhances the efficacy of docetaxel in a triple-negative breast cancer model A. R R Maia, J. De Man, U. Boon, A. Janssen, J. Y. Song, M. Omerzu, J. G. Sterrenburg, M. B W Prinsen, N. Willemsen-Seegers, J. A D M De Roos, A. M. Van Doornmalen, J. C M Uitdehaag, G. J P L Kops, J. Jonkers, R. C. Buijsman, Guido J R Zaman, R. H. Medema
Annals of Oncology, 2015, vol. 26, p.2180-2192

Molecular basis underlying resistance to Mps1/TTK inhibitors A. Koch, A. Maia, A. Janssen, R. H. Medema
Oncogene, 2015, vol. 35, p.2518–2528