András Spaan

Associate Professor - medical

Strategic program(s):

Contact

aspaan@umcutrecht.nl

Pure profile

Research groups

Human genetics of host-microbe interactions

Research aim

We study the human genetic and immunological determinants of host-pathogen interactions

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Recent publications

All publications

A common form of dominant human IFNAR1 deficiency impairs IFN-α and -ω but not IFN-β-dependent immunity Fahd Al Qureshah, Jérémie Le Pen, Nicole A. de Weerd, Marcela Moncada-Velez, Marie Materna, Danielc Lin, Baptiste Milisavljevic, Fernanda Vianna, Lucy Bizien, Lazaro Lorenzo, Marc Lecuit, Jean David Pommier, Sevgi Keles, Tayfun Ozcelik, Sigifredo Pedraza-Sanchez, Nicolas de Prost, Loubna El Zein, Hassan Hammoud, Lisa F P Ng, Rabih Halwani, Narjes Saheb Sharif-Askari, Yu Lung Lau, Anthony R. Tam, Neha Singh, Sagar Bhattad, Yackov Berkun, Wasun Chantratita, Raúl Aguilar-López, Mohammad Shahrooei, Laurent Abel, Paul Bastard, Emmanuelle Jouanguy, Vivien Béziat, Peng Zhang, Charles M Rice, Aurélie Cobat, Shen Ying Zhang, Paul J. Hertzog, Jean Laurent Casanova, Qian Zhang, Alessandro Aiuti, Saleh Al-Muhsen, Ana Bertha Alcántara-Garduño, Evangelos Andreakos, Andrés A. Arias, Hagit Baris Feldman, Alexandre Bolze, Alessandro Borghesi, Ahmed A. Bousfiha, Petter Brodin, John Christodoulou, Roger Colobran, Antonio Condino-Neto, Sotiriјa Duvlis, Xavier Duval, Munis Dündar, Soha Fakhreddine, Jacques Fellay, Carlos Flores, José Luis Franco, Guy Gorochov, Peter K. Gregersen, David Hagin, Rabih Halwani, María Teresa Herrera, Ivan Fan Ngai Hung, Yu Lung Lau, Daniel Leung, Tom Le-Voyer, Davood Mansouri, Jesús Mercado-García, Isabelle Meyts, Trine H. Mogensen, Lisa F.P. Ng, Antonio Novelli, Giuseppe Novelli, Satoshi Okada, Firat Ozcelik, Rebeca Perez de Diego, Jordi Perez-Tur, Graziano Pesole, Anne Puel, Laurent Renia, Igor Resnick, Carlos Rodríguez-Gallego, Manal Sbeity, Sahar Sedighzadeh, Mohammad Shahrooei, Pere Soler-Palacín, András N. Spaan, Stuart G. Tangye, Ahmad Abou Tayoun, Şehime Gülsün Temel, Christian Thorball, Ibrahim Torktaz, Sophie Trouillet-Assant, Stuart E. Turvey, K. M. Furkan Uddin, Fernanda Sales Luiz Vianna, Donald C. Vinh, Oscar Zabaleta-Martínez, Chanreaksmey Eng, Kimrong Bun, Mr Mengheng Oum, Patrice Piola, Arnaud Tarantola, Mey Channa, Veasna Duong, Philippe Buchy, Chris Gorman, Yoann Crabol, Philippe Dussart, M. Bunleat, M. Panha, M. Kanarith Sim, Em Bunnakea, Denis Laurent, Heng Sothy, Ky Santy, Anousone Douangnouvong, Danoy Chommanam, Khansoudaphone Phakhounthong, Manivanh Vongsouvath, Malee Seephone, Bountoy Sibounheunang, Sayaphet Rattanavong, Viengmon Davong, Malavanh Vongsouvath, Mayfong Mayxay, Audrey Dubot-Pérès, Paul N. Newton, Sommanikhone Phangmanixay, Khounthavy Phongsavath, Dang Duc Anh, Mr Do Quyen, Tran Thi Mai Hung, Nguyen Thi Thu Thuy, Mr Luong Minh Tan, Anh Tuan Pham, Nguyen Hien, Do Thu Huong, Le Thanh Hai, Nguyen Van Lam, Pham Nhat An, Phan Huu Phuc, Phung Bich Thuy, Tran Thi Thu Huong, Chaw Su Hlaing, Aye Mya Min Aye, Cho Thair, Kyaw Linn, May July, Win Thein, Latt Latt Kyaw, Htay Htay Tin, Ommar Swe Tin, Khin Yi Oo, Yoann Crabol, Magali Herrant, Magali Lago, Maud Seguy, Marc Jouan, Lukas Hafner, Philippe Pérot, Marc Eloit, Marc Lecuit, Olivier Lortholary, Julien Capelle, Bruno Rosset, Veronique Chevalier, Jérôme Honnorat, Anne Laurie Pinto, Auey Dubot-Peres, Xavier de Lamballerie, Kevin Bleakley, Committee Bernadette Murgue, Catherine Ferrant, Christian Devaux, Hervé Tissot-Dupont, Jean Paul Moatti, Mayfong Mayxay, Pascal Bonnet, Didier Fontenille, Jean François Delfraissy, Patrice Debré, Benoit Durand
Journal of Experimental Medicine, 2025, vol. 222

Higher COVID-19 pneumonia risk associated with anti-IFN-α than with anti-IFN-ω auto-Abs in children Paul Bastard, Adrian Gervais, Maki Taniguchi, Liisa Saare, Karita Särekannu, Tom Le Voyer, Quentin Philippot, Jérémie Rosain, Lucy Bizien, Takaki Asano, Marina Garcia-Prat, Alba Parra-Martínez, Mélanie Migaud, Miyuki Tsumura, Francesca Conti, Alexandre Belot, Jacques G. Rivière, Tomohiro Morio, Junko Tanaka, Etienne Javouhey, Filomeen Haerynck, Sotirija Duvlis, Tayfun Ozcelik, Sevgi Keles, Yacine Tandjaoui-Lambiotte, Simon Escoda, Maya Husain, Qiang Pan-Hammarström, Lennart Hammarström, Gloria Ahlijah, Anthony Abi Haidar, Camille Soudee, Vincent Arseguel, Hassan Abolhassani, Sabina Sahanic, Ivan Tancevski, Yoko Nukui, Seiichi Hayakawa, George P. Chrousos, Athanasios Michos, Elizabeth Barbara Tatsi, Filippos Filippatos, Agusti Rodriguez-Palmero, Jesus Troya, Imran Tipu, Isabelle Meyts, Lucie Roussel, Sisse Rye Ostrowski, Laire Schidlowski, András N. Spaan, , ,
Journal of Experimental Medicine, 2024, vol. 221

OTULIN and Muller’s morphs András N. Spaan
Journal of Experimental Medicine, 2024, vol. 221

Lack of association between classical HLA genes and asymptomatic SARS-CoV-2 infection Astrid Marchal, Elizabeth T. Cirulli, Iva Neveux, Evangelos Bellos, Ryan S. Thwaites, Kelly M. Schiabor Barrett, Yu Zhang, Ivana Nemes-Bokun, Mariya Kalinova, Andrew Catchpole, Stuart G. Tangye, András N. Spaan, Justin B. Lack, Jade Ghosn, Charles Burdet, Guy Gorochov, Florence Tubach, Pierre Hausfater, Laurent Abel, Alessandro Aiuti, Saleh Al-Muhsen, Fahd Al-Mulla, Ali Amara, Mark S. Anderson, Evangelos Andreakos, Andrés A. Arias, Lisa M. Arkin, Hagit Baris Feldman, Paul Bastard, Alexandre Belot, Catherine M. Biggs, Dusan Bogunovic, Alexandre Bolze, Anastasiia Bondarenko, Alessandro Borghesi, Ahmed A. Bousfiha, Petter Brodin, Yenan Bryceson, Manish J. Butte, Jean Laurent Casanova, Giorgio Casari, John Christodoulou, Aurélie Cobat, Roger Colobran, Antonio Condino-Neto, Antoine Khalil, David T.P. Buis, Lucas Fleuren, Charlotte Teunissen, Marc van der Valk, , , , , , , , ,
Human Genetics and Genomics Advances, 2024, vol. 5

OTULIN Haploinsufficiency-Related Fasciitis and Skin Necrosis Treated by TNF Inhibition Rob J W Arts, Tristan J van der Linden, Caspar I van der Made, Marianne M C Hendriks, Wouter A van der Heijden, Quirijn de Mast, Janneke H M Schuurs-Hoeijmakers, Annet Simons, András N Spaan, Catharina M Mulders-Manders, Frank L van de Veerdonk
Journal of Clinical Immunology, 2024, vol. 44

Human IRF1 governs macrophagic IFN-γ immunity to mycobacteria Jérémie Rosain, Anna-Lena Neehus, Jérémy Manry, Rui Yang, Jérémie Le Pen, Wassim Daher, Zhiyong Liu, Yi-Hao Chan, Natalia Tahuil, Özden Türel, Mathieu Bourgey, Masato Ogishi, Jean-Marc Doisne, Helena M Izquierdo, Takayoshi Shirasaki, Tom Le Voyer, Antoine Guérin, Paul Bastard, Marcela Moncada-Vélez, Ji Eun Han, Taushif Khan, Franck Rapaport, Seon-Hui Hong, Andrew Cheung, Kathrin Haake, Barbara C Mindt, Laura Pérez, Quentin Philippot, Danyel Lee, Peng Zhang, Darawan Rinchai, Fatima Al Ali, Manar Mahmoud Ahmad Ata, Mahbuba Rahman, Jessica N Peel, Søren Heissel, Henrik Molina, Yasemin Kendir-Demirkol, Rasheed Bailey, Shuxiang Zhao, Jonathan Bohlen, Yoann Seeleuthner, Marie Roelens, Lazaro Lorenzo, Camille Soudée, María Elvira Josefina Paz, María Laura González, Mohamed Jeljeli, Jean Soulier, Serge Romana, Anne-Sophie L'Honneur, Marie Materna, Rubén Martínez-Barricarte, Mathieu Pochon, Carmen Oleaga-Quintas, Alexandre Michev, Mélanie Migaud, Romain Lévy, Marie-Alexandra Alyanakian, Flore Rozenberg, Carys A Croft, Guillaume Vogt, Jean-François Emile, Laurent Kremer, Cindy S Ma, Jörg H Fritz, Stanley M Lemon, András N Spaan, Nicolas Manel, Laurent Abel, Margaret R MacDonald, Stéphanie Boisson-Dupuis, Nico Marr, Stuart G Tangye, James P Di Santo, Qian Zhang, Shen-Ying Zhang, Charles M Rice, Vivien Béziat, Nico Lachmann, David Langlais, Jean-Laurent Casanova, Philippe Gros, Jacinta Bustamante
Cell, 2023, vol. 186, p.621-645.e33

External positions

Visiting Fellow at the St. Giles Laboratory of Human Genetics of Infectious Diseases - Wetenschappelijk samenwerkingsverband MMB UMCU en Casanova Lab Rockefeller University NY - The Rockefeller University