Alexander Yermanos

Assistant Professor

Strategic program(s):

Contact

ayermano@umcutrecht.nl

Pure profile

Research groups

Computational biology & systems immunology

Research aim

We integrate experimental and computational immunology to understand, predict, and engineer adaptive immune recognition. This includes developing software, profiling of immune responses, and designing computationally-guided therapeutics.

Go to group

Computational immunology core

Research aim

We bring together bioinformaticians, biostatisticians and mathematical modelers to develop new methodologies to interpret the complex datasets that are being generated by immunologists, and form a bridge between the wet and dry labs and the clinic.

Go to group

Recent publications

All publications

Learning immune receptor representations with protein language models Andreas Dounas, Tudor Stefan Cotet, Alexander Yermanos
2024

Clonally expanded IgG antibody-secreting cells preferentially target influenza nucleoprotein following homologous and heterologous infections Raphael Kuhn, Camilla Panetti, Marco Venerito, Hathaichanok Phandee, Lucas Stalder, Danielle Shlesinger, Vittoria Martinolli D'Arcy, Kai Lin Hong, Daphne van Ginneken, Alessandro Genovese, Nicole Joller, Annette Oxenius, Sai T. Reddy, Alexander Yermanos
2024

Protein language model pseudolikelihoods capture features of in vivo B cell selection and evolution Daphne van Ginneken, Anamay Samant, Karlis Daga-Krumins, Andreas Agrafiotis, Evgenios Kladis, Sai T. Reddy, Alexander Yermanos
2024

A novel bioinformatics pipeline for the identification of immune inhibitory receptors as potential therapeutic targets Akashdip Singh, Alberto Miranda Bedate, Helen J von Richthofen, Saskia V Vijver, Michiel van der Vlist, Raphael Kuhn, Alexander Yermanos, Jürgen J Kuball, Can Kesmir, M Ines Pascoal Ramos, Linde Meyaard
eLife, 2024, vol. 13

Echidna Jiami Han, Solène Masserey, Danielle Shlesinger, Raphael Kuhn, Chrysa Papadopoulou, Andreas Agrafiotis, Victor Kreiner, Raphael Dizerens, Kai-Lin Hong, Cédric Weber, Victor Greiff, Annette Oxenius, Sai T Reddy, Alexander Yermanos
Bioinformatics advances, 2022, vol. 2

Phenotypic determinism and stochasticity in antibody repertoires of clonally expanded plasma cells Daniel Neumeier, Alexander Yermanos, Andreas Agrafiotis, Lucia Csepregi, Tasnia Chowdhury, Roy A Ehling, Raphael Kuhn, Tudor-Stefan Cotet, Raphaël Brisset-Di Roberto, Mariangela Di Tacchio, Renan Antonialli, Dale Starkie, Daniel J Lightwood, Annette Oxenius, Sai T Reddy
Proceedings of the National Academy of Sciences of the United States of America, 2022, vol. 119

External positions

Project Director, Global Immunogenomics - Lead research team and involved in global engagement - Botnar Institute of Immune Engineering