Alexander Yermanos

Assistant Professor

Strategic program(s):

Contact

ayermano@umcutrecht.nl

Pure profile

Research groups

Computational biology & systems immunology

Research aim

We integrate experimental and computational immunology to understand, predict, and engineer adaptive immune recognition. This includes developing software, profiling of immune responses, and designing computationally-guided therapeutics.

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Computational immunology core

Research aim

We bring together bioinformaticians, biostatisticians and mathematical modelers to develop new methodologies to interpret the complex datasets that are being generated by immunologists, and form a bridge between the wet and dry labs and the clinic.

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Recent publications

All publications

A novel bioinformatics pipeline for the identification of immune inhibitory receptors as potential therapeutic targets Akashdip Singh, Alberto Miranda Bedate, Helen J von Richthofen, Saskia V Vijver, Michiel van der Vlist, Raphael Kuhn, Alexander Yermanos, Jürgen J Kuball, Can Kesmir, M Ines Pascoal Ramos, Linde Meyaard
eLife, 2024, vol. 13

Protein language model pseudolikelihoods capture features of in vivo B cell selection and evolution Daphne van Ginneken, Anamay Samant, Karlis Daga-Krumins, Andreas Agrafiotis, Evgenios Kladis, Sai T. Reddy, Alexander Yermanos
2024

Learning immune receptor representations with protein language models Andreas Dounas, Tudor Stefan Cotet, Alexander Yermanos
2024

Clonally expanded IgG antibody-secreting cells preferentially target influenza nucleoprotein following homologous and heterologous infections Raphael Kuhn, Camilla Panetti, Marco Venerito, Hathaichanok Phandee, Lucas Stalder, Danielle Shlesinger, Vittoria Martinolli D'Arcy, Kai Lin Hong, Daphne van Ginneken, Alessandro Genovese, Nicole Joller, Annette Oxenius, Sai T. Reddy, Alexander Yermanos
2024

Profiling the specificity of clonally expanded plasma cells during chronic viral infection by single-cell analysis Daniel Neumeier, Alessandro Pedrioli, Alessandro Genovese, Ioana Sandu, Roy Ehling, Kai-Lin Hong, Chrysa Papadopoulou, Andreas Agrafiotis, Raphael Kuhn, Danielle Shlesinger, Damiano Robbiani, Jiami Han, Laura Hauri, Lucia Csepregi, Victor Greiff, Doron Merkler, Sai T Reddy, Annette Oxenius, Alexander Yermanos
European Journal of Immunology, 2022, vol. 52, p.297-311

SARS-CoV-2 reactive and neutralizing antibodies discovered by single-cell sequencing of plasma cells and mammalian display Roy A Ehling, Cédric R Weber, Derek M Mason, Simon Friedensohn, Bastian Wagner, Florian Bieberich, Edo Kapetanovic, Rodrigo Vazquez-Lombardi, Raphaël B Di Roberto, Kai-Lin Hong, Camille Wagner, Michele Pataia, Max D Overath, Daniel J Sheward, Ben Murrell, Alexander Yermanos, Andreas P Cuny, Miodrag Savic, Fabian Rudolf, Sai T Reddy
Cell Reports, 2022, vol. 38

External positions

Project Director, Global Immunogenomics - Lead research team and involved in global engagement - Botnar Institute of Immune Engineering