Profile photo Alain van Mil

Alain van Mil

Assistant Professor

Biography

Dr. van Mil is a biomedical scientist and group leader in the laboratory of Experimental Cardiology within the Regenerative Medicine Center Utrecht. He obtained his PhD in 2012 in the University Medical Center Utrecht where he studied the role of microRNAs in cardiac regeneration and subsequently moved to the US for a postdoctoral fellowship in Sanford-Burnham, La Jolla, where he first came to work with pluripotent stem cells and in vitro 3D cardiac tissue models. After his return to the Netherlands, he continued his research in the UMC Utrecht using pluripotent stem cells, applying them for cardiac disease modelling. In 2016 he moved to the Regenerative Medicine Center Utrecht, where he established an induced pluripotent stem cell (iPSC) facility for the generation of iPSCs and iPSC-derived cardiac cells which are key to his research. His research team aims to identify new therapeutic targets and develop regenerative treatments for heart failure, by using advanced human in vitro cardiac disease models and innovative cardiac tissue engineering approaches, using iPSC technology, biomaterials and 3D printing.

Recent publications

Identification of picornavirus proteins that inhibit de novo nucleotide synthesis during infection Lonneke V Nouwen, Esther A Zaal, Inge Buitendijk, Marleen Zwaagstra, Chiara Aloise, Arno L W van Vliet, Jelle G Schipper, Alain van Mil, Celia R Berkers, Frank J M van Kuppeveld
PLoS pathogens, 2025, vol. 21
Uncovering cell type-specific phenotypes using a novel human in vitro model of transthyretin amyloid cardiomyopathy Jiabin Qin, Qiangbing Yang, Asier Ullate-Agote, Vasco Sampaio-Pinto, Laura Florit, Inge Dokter, Chrysoula Mathioudaki, Lotte Middelberg, Pilar Montero-Calle, Paula Aguirre-Ruiz, Joana de Las Heras Rojo, Zhiyong Lei, Zeping Qiu, Jin Wei, Pim van der Harst, Felipe Prosper, Manuel M Mazo, Olalla Iglesias-García, Monique C Minnema, Joost P G Sluijter, Marish I F J Oerlemans, Alain van Mil
Stem cell research & therapy, 2025, vol. 16
Engineering anti-BCMA CAR T cells for enhancing myeloma killing efficacy via apoptosis regulation Thomas Kimman, Marta Cuenca, Ralph G Tieland, Dedeke Rockx-Brouwer, Jasmijn Janssen, Benjamin Motais, Anne Slomp, Corine Pleijte, Sabine Heijhuurs, Angelo D Meringa, Wendy Boschloo, Douwe Mt Bosma, Sanne Kroos, Vania Lo Presti, Joost P G Sluijter, Stefan Nierkens, Niels Bovenschen, Jürgen Kuball, Alain van Mil, Monique C Minnema, Zsolt Sebestyén, Victor Peperzak
Nature Communications, 2025, vol. 16
Engineered heart tissue patches Alain van Mil, Jasmijn Janssen, Eva van Rooij
Cell stem cell, 2025, vol. 32, p.505-507
Billion-Scale Expansion of Functional hiPSC-Derived Cardiomyocytes in Bioreactors Through Oxygen Control and Continuous Wnt Activation Pedro Vicente, Lara R. Inocêncio, Asier Ullate-Agote, Ana F. Louro, João Jacinto, Beatriz Gamelas, Olalla Iglesias-García, Patxi San Martin-Uriz, Paula Aguirre-Ruiz, Gonzalo R. Ríos-Muñoz, María Eugenia Fernández-Santos, Alain van Mil, Joost P.G. Sluijter, Felipe Prósper, Manuel M.Mazo Vega, Paula M. Alves, Margarida Serra
Advanced Science, 2025, vol. 12
Correction to Juntao Fang, Qiangbing Yang, Renée G.C. Maas, Michele Buono, Bram Meijlink, Dyonne Lotgerink Bruinenberg, Ernest Diez Benavente, Michal Mokry, Alain van Mil, Li Qian, Marie‑José Goumans, Raymond Schiffelers, Zhiyong Lei, Joost P.G. Sluijter
Stem Cell Research and Therapy, 2024, vol. 15