Profile photo Alain van Mil

Alain van Mil

Assistant Professor

Biography

Dr. van Mil is a biomedical scientist and group leader in the laboratory of Experimental Cardiology within the Regenerative Medicine Center Utrecht. He obtained his PhD in 2012 in the University Medical Center Utrecht where he studied the role of microRNAs in cardiac regeneration and subsequently moved to the US for a postdoctoral fellowship in Sanford-Burnham, La Jolla, where he first came to work with pluripotent stem cells and in vitro 3D cardiac tissue models. After his return to the Netherlands, he continued his research in the UMC Utrecht using pluripotent stem cells, applying them for cardiac disease modelling. In 2016 he moved to the Regenerative Medicine Center Utrecht, where he established an induced pluripotent stem cell (iPSC) facility for the generation of iPSCs and iPSC-derived cardiac cells which are key to his research. His research team aims to identify new therapeutic targets and develop regenerative treatments for heart failure, by using advanced human in vitro cardiac disease models and innovative cardiac tissue engineering approaches, using iPSC technology, biomaterials and 3D printing.

Recent publications

Vitamin C facilitates direct cardiac reprogramming by inhibiting reactive oxygen species Juntao Fang, Qiangbing Yang, Renée G C Maas, Michele Buono, Bram Meijlink, Dyonne Lotgerink Bruinenberg, Ernest Diez Benavente, Michal Mokry, Alain van Mil, Li Qian, Marie-José Goumans, Raymond Schiffelers, Zhiyong Lei, Joost P G Sluijter
Stem Cell Research & Therapy [E], 2024, vol. 15, p.19
Hypothermic and cryogenic preservation of cardiac tissue-engineered constructs Jasmijn Janssen, Nino Chirico, Madison J Ainsworth, Gerardo Cedillo-Servin, Martina Viola, Inge Dokter, Tina Vermonden, Pieter A Doevendans, Margarida Serra, Ilja K Voets, Jos Malda, Miguel Castilho, Linda W van Laake, Joost P G Sluijter, Vasco Sampaio-Pinto, Alain van Mil
Biomaterials science, 2024, vol. 12, p.3866-3881
Generation, High-Throughput Screening, and Biobanking of Human-Induced Pluripotent Stem Cell-Derived Cardiac Spheroids Renee G C Maas, Tess Beekink, Nino Chirico, Christian J B Snijders Blok, Inge Dokter, Vasco Sampaio-Pinto, Alain van Mil, Pieter A Doevendans, Jan W Buikema, Joost P G Sluijter, Francesca Stillitano
Journal of visualized experiments : JoVE, 2023
Convergence of melt electrowriting and extrusion-based bioprinting for vascular patterning of a myocardial construct Madison Jade Ainsworth, Nino Chirico, Mylène de Ruijter, Andrei Hrynevich, Inge Dokter, Joost P.G. Sluijter, Jos Malda, Alain van Mil, Miguel Castilho
Biofabrication, 2023, vol. 15
Fusogenic Coiled-Coil Peptides Enhance Lipid Nanoparticle-Mediated mRNA Delivery upon Intramyocardial Administration Ye Zeng, Mariona Estapé Senti, M. Clara I. Labonia, Panagiota Papadopoulou, Maike A.D. Brans, Inge Dokter, Marcel H. Fens, Alain van Mil, Joost P.G. Sluijter, Raymond M. Schiffelers, Pieter Vader, Alexander Kros
ACS Nano, 2023, vol. 17, p.23466-23477