Throughout history, the dance between infection and immunity has brought both devastation and discovery. This relationship transcends the confines of time, continuously influencing our daily lives regardless of how advanced our research becomes. To navigate the future of this field, we must first understand its history. The 2025 Infection and Immunity Symposium will take us on a journey through time—exploring how our immune system has evolved alongside pathogens and unveiling the next wave of therapeutic innovations. The story of infection and immunity is still being written—and the next chapter is ours to create.