Recently ARCADIA has started as an official and certified PamGene service provider. With our PamStation Multiplex Kinase platform we can offer a high-capacity analysis service revealing the bigger picture of cellular signaling which provides mechanistic insights, needed to fully understand diseases and cell alterations. It opens opportunities for a wide range of rapid and non-invasive applications and is applied in the areas of fundamental science, translational research and diagnostics.
PamGene’s functional kinase assay is activity-based and detects protein kinase activity directly in cellular and tissue lysates, through measuring peptide phosphorylation by protein kinases. PamGene’s technology is used to gain insights into discriminative drug responses, analyzing and optimizing kinase inhibitors and discovery of novel biomarkers, targets and pathways.
PamGene multiplex chip technology covers over 380 Kinases. Kinases that are known or predicted to phosphorylate substrate peptides on the PTK and STK PamChip® are mapped from select databases (HPRD, Kinexus, Phosphosite PLUS, Reactome, Phopho.elm, UniPROT) and projected on the kinome tree.
The technology enables to measure in different sample types and volumes and provides quantifiable, active -and functional kinase results with high throughput, exceptional sensitivity and specificity.
If you choose to send your sample for our experts to run on the PamStation platform, we can assist you with the following:
Send your sample to arcadia@umcutrecht.nl.
From Substrate phosphorylation to kinases and cellular signaling:
