Medical Metabolomics Facility (MFF)

Research highlights

Engelen S.E. Lipoproteins act as vehicles for lipid antigen delivery and activation of invariant natural killer T cells. JCI Insight 8(2023)158089
https://pubmed.ncbi.nlm.nih.gov/36976644/

Wang, M.J. ea Metabolic rewiring in keratinocytes by miR-31-5p identifies therapeutic intervention for psoriasis. EMBO Mol Med 15(2023)15674
https://pubmed.ncbi.nlm.nih.gov/36855912/

de Wit, K. ea Rifaximin stimulates nitrogen detoxification by PXR-independent mechanisms in human small intestinal organoids. Liver Int 43(2023)649
https://pubmed.ncbi.nlm.nih.gov/36463417/

Ludikhuize M.C. ea Rewiring glucose metabolism improves 5-FU efficacy in p53-deficient/KRAS G12D glycolytic colorectal tumors. Commun Biol 5(2022)1159
https://pubmed.ncbi.nlm.nih.gov/36316440/

Otria A. ea Fatty Acid and Carnitine Metabolism Are Dysregulated in Systemic SclerosisPatients. Front Immunol 11(2020)822
https://pubmed.ncbi.nlm.nih.gov/32528464/

Driehuis, E. ea Pancreatic cancer organoids recapitulate disease and allow personalized drug
screening. Proc Natl Acad Sci USA 116(2019)26580
https://pubmed.ncbi.nlm.nih.gov/31818951/

Verhagen, F.H. ea Aqueous Humor Analysis Identifies Higher Branched Chain Amino Acid Metabolism as a Marker for Human Leukocyte Antigen-B27 Acute Anterior Uveitis and Disease Activity. Am J Ophtalmol 198(2019)97
https://pubmed.ncbi.nlm.nih.gov/30312576/

Van Rijn, J.M. ea Intestinal Failure and Aberrant Lipid Metabolism in Patients With DGAT1
Deficiency. Gastroenterelogy 155(2018)130
https://pubmed.ncbi.nlm.nih.gov/29604290/

Rodriguez-Colman, M.J. ea Interplay between metabolic identities in the intestinal crypt supports stem cell function. Nature 543(2017)424
https://pubmed.ncbi.nlm.nih.gov/28273069/

Stout,G.J. ea Insulin/IGF-1-mediated longevity is marked by reduced protein metabolism. Mol Syst Biol 9(2013)679
https://pubmed.ncbi.nlm.nih.gov/23820781/

Roodhart, J.M.L ea Mesenchymal Stem Cells Induce Resistance to Chemotherapy through the Release of Platinum-Induced Fatty Acids. Cancer Cell 20(2011)370
https://pubmed.ncbi.nlm.nih.gov/21907927/