Complex human genetics focuses on the analysis and interpretation of genetic data. It involves the application of statistical methods to understand the genetic basis of complex traits and diseases.
Key areas include the identification of genetic variants associated with phenotypic variation, for instance through genome-wide association studies (GWAS), heritability estimation (for a specific trait or between traits), and polygenic risk scores (PRS). Statistical genetics plays a crucial role in analyzing large datasets from array genotyping and sequencing technologies.
Results are aimed to:
Within the UMC Utrecht, five research groups are involved in complex genetics research, covering a range of neurological and cardiovascular diseases.