Yvonne Vercoulen

Associate Professor

Strategic program(s):

Biography

See Vercoulen lab website >

Strategic program(s):

Contact

yvercou2@umcutrecht.nl

Pure profile

Research groups

Inflammatory bowel diseases

Research aim

Our research is focused on the elucidation of the pathogenesis of Inflammatory bowel diseases (IBD), personalized medicine and on a severe complication of IBD: colitis-associated colorectal carcinoma.

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Tissue immune microenvironment: spatial biology

Research aim

Understand the immune mechanisms that underly cancer and inflammatory disease, to impact diagnosis and therapeutic strategies in patients.

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Tissue immunology

Research aim

Our mission is to comprehensively understand, monitor, and target immune-mediated inflammatory diseases such as IBD, AD and systemic autoimmune diseases. We aim to unravel (tissue) immune dysregulation and induce long-lasting disease modification.

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Primary immunodeficiency

Research aim

To address unmet medical needs by detecting novel primary immunodeficiency, and improving clinical practice by optimizing diagnosis, prognosis and treatment of disease.

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Recent publications

All publications

Spatial transcriptomics and immunophenotyping uncover chronic inflammation-induced immune adaptations favoring dysplasia development in patients at risk of colitis-associated cancer Sofía Frigerio, Hina N Khan, Mojtaba Amini, Bregje Mol, Andra Neefjes-Borst, Manon E Wildenberg, Cyriel Y Ponsioen, Geert R D'haens, Yvonne Vercoulen, Joep Grootjans
Journal of Crohn's & Colitis, 2025, vol. 19

High-plex imaging of hepatoblastoma and adjacent liver in pediatric patients reveals a predominant myeloid infiltrate expressing immune-checkpoints Daniëlle Krijgsman, Stephanie A Schubert, Lianne J Kraaier, Yuyan Lu, Kristof van Avondt, Meggy E L Verdonschot, Jeanette H W Leusen, Marius C van den Heuvel, Ruben H de Kleine, Vincent E de Meijer, Kathelijne C J Kraal, Ronald R de Krijger, József Zsiros, Weng Chuan Peng, Yvonne Vercoulen
Cancer Immunology, Immunotherapy, 2025, vol. 74

Anti-PD-1 treatment response is associated with the influx of circulating myeloid and T-cell subsets into the metastatic melanoma tumor microenvironment S Van Dam, D Krijgsman, E Küçükköse, M E L Verdonschot, M Amini, W A M Blokx, M J M Van Eijs, R J Verheijden, O Kranenburg, K P M Suijkerbuijk, J H W Leusen, Y Vercoulen
British Journal of Cancer, 2025, vol. 133, p.1250-1264

Lactate controls cancer stemness and plasticity through epigenetic regulation Nguyen T B Nguyen, Sira Gevers, Rutger N U Kok, Lotte M Burgering, Hannah Neikes, Ninouk Akkerman, Max A Betjes, Marlies C Ludikhuize, Can Gulersonmez, Edwin C A Stigter, Yvonne Vercoulen, Jarno Drost, Hans Clevers, Michiel Vermeulen, Jeroen S van Zon, Sander J Tans, Boudewijn M T Burgering, Maria J Rodríguez Colman
Cell Metabolism, 2025, vol. 37, p.903-919.e10

Development of a Caco-2-based intestinal mucosal model to study intestinal barrier properties and bacteria-mucus interactions Evelien Floor, Jinyi Su, Maitrayee Chatterjee, Elise S Kuipers, Noortje IJssennagger, Faranak Heidari, Laura Giordano, Richard W Wubbolts, Silvia M Mihăilă, Daphne A C Stapels, Yvonne Vercoulen, Karin Strijbis
Gut Microbes, 2024, vol. 17

Dietary cystine restriction increases the proliferative capacity of the small intestine of mice Judith C.W. de Jong, Kristel S. van Rooijen, Edwin C.A. Stigter, M. Can Gülersönmez, Marcel R. de Zoete, Janetta Top, Matthijs J.D. Baars, Yvonne Vercoulen, Folkert Kuipers, Saskia W.C. Van Mil, Noortje Ijssennagger
PLoS ONE, 2024, vol. 19