Michael van Es

Associate Professor - medical

Strategic program(s):

Contact

mes3@umcutrecht.nl

Pure profile

Research groups

Clinical spectrum of motor neuron disease

Research aim

Motor neuron disease (MND) are a collection of disorder that primarily lead to progressive weakness and/or spasticity. The goal is better understand and treat the extensive clinical heterogeneity in MND.

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Recent publications

All publications

Diagnostic Revision From Primary Lateral Sclerosis to Amyotrophic Lateral Sclerosis Eva M.J. de Boer, Sean W. Willemse, Jan H. Veldink, H. Stephan Goedee, Alexander F.J.E. Vrancken, Wouter van Rheenen, Henk Jan Westeneng, Leonard H. van den Berg, Michael A. van Es
Neurology, 2026, vol. 106

Small RNA sequencing identifies serum tDR-1:34-Gly-GCC tiRNA levels as a biomarker for survival in amyotrophic lateral sclerosis Koen C. Demaegd, Lindy Kool, Sharada Baindoor, Paul D. Donovan, Junyi Su, Henk Jan Westeneng, Ruben P.A. van Eijk, Grainne Geoghegan, Elena Perez Morrissey, Luise Halang, Koen Poesen, Pegah Masrori, Hesham A.Y. Gibriel, Elisabeth Jirström, Morten T. Venø, Jørgen Kjems, Orla Hardiman, Jan H. Veldink, Kevin Kenna, Leonard H. van den Berg, Philip Van Damme, Jochen H.M. Prehn, Michael A. van Es
iScience, 2026, vol. 29

Large-scale exome analyses reveal new rare variant contributions in amyotrophic lateral sclerosis Paul J. Hop, Maarten Kooyman, Brendan J. Kenna, Ramona A.J. Zwamborn, Kristel R. van Eijk, Yan Wang, Charlotte H. van Dijk, Erwin Bekema, Wouter van Rheenen, Paul Beele, Joke J.F.A. van Vugt, Mamede de Carvalho, Leonard H. van den Berg, Philip Van Damme, Bradley N. Smith, Ahmad Al Khleifat, Alfredo Iacoangeli, Johnathan Cooper-Knock, Bradley N. Smith, Simon Topp, Anneke J. van der Kooi, Vera Fominykh, Vivian Drory, Yossef Lerner, Yehuda Shovman, Dominic B. Rowe, Kelly L. Williams, Russell L. McLaughlin, Jessica Hurt, Yunfeng Huang, Chia Yen Chen, Ellen Tsai, Heiko Runz, Eleonora Aronica, Ewout J.N. Groen, Michael A. van Es, R. Jeroen Pasterkamp, Sali M.K. Farhan, Fleur C. Garton, Allan F. McRae, Pamela A. McCombe, Robert D. Henderson, Dongsheng Fan, Lenka Šlachtová, Helle Høyer, Agnes L. Nishimura, Philip Van Damme, Leonard H. van den Berg, Kevin P. Kenna, Jan H. Veldink, , , ,
Nature genetics, 2026, vol. 58, p.717-725

Bi-allelic intermediate ATXN2 repeat expansions are associated with slow progressing, leg-onset familial ALS Koen Cedric Demaegd, Wouter Koole, Joke JFA Van Vugt, Jan Willem Dankbaar, Jeroen Hendrikse, A. Nazlı Başak, Mamede De Carvalho, Philippe Corcia, Philippe Codron, Emilien Bernard, Claire Guissart, Philippe Couratier, Mónica Povedano Panades, Pieter A. Van Doorn, Bart P. Warrenburg, Johnathan Cooper-Knock, R. Jeroen Pasterkamp, Wouter Van Rheenen, Philip Van Damme, Leonard H. Van den Berg, Jan Herman Veldink, Michael A. Van Es, Patrick Vourc’h, Orla Hardiman, Russell McLaughin, Marc Gotkine, Yossef Lerner, Vivian Drory, Nicola Ticozzi, Vincenzo Silani, Teresa Salas, S. Jesus, Mora Pardina, Peter Andersen, Markus Weber, Ammar Al-Chalabi, Chris Shaw, Pamela J. Shaw, Karen E. Morrison, John E. Landers, Jonathan D. Glass, Clifton L. Dalgard
BMJ Neurology Open, 2026, vol. 8

The role of disease-associated short tandem repeats in amyotrophic lateral sclerosis Joke J F A van Vugt, Ramona A J Zwamborn, Egor Dolzhenko, Michael A Eberle, Ben Weisburd, Erwin Bekema, Maarten Kooyman, Bi-Nan Wang, Erik-Jan Kamsteeg, Monique Losekoot, Frank Baas, Camilla Novy, Helle Høyer, Ruben P A van Eijk, Michael A van Es, Wouter van Rheenen, Ammar Al-Chalabi, Leonard H van den Berg, Jan H Veldink,
Brain communications, 2025, vol. 7

Serum small non-coding RNA define molecular subtypes in amyotrophic lateral sclerosis Sharada Baindoor, Hesham A.Y. Gibriel, Lindy Kool, Junyi Su, Koen C. Demaegd, Morten T. Venø, Leonard H. Van Den Berg, Jørgen Kjems, Michael A. Van Es, Jochen H.M. Prehn
Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration, 2025, vol. 27, p.383-392